BioRestorative Therapies Announces Notice of Allowance for New Patent Application in Japan and Expansion of ThermoStem® IP Portfolio
February 02 2022 - 8:00AM
BioRestorative Therapies, Inc. (the “Company” or “BioRestorative”)
(NASDAQ: BRTX), a life sciences company focused on stem cell-based
therapies, today announced that the Japanese Patent Office has
issued a notice of allowance for a patent application related to
the Company’s metabolic ThermoStem® Program. The notice of
allowance was issued on January 26, 2022 and is related to a new
patent application not previously announced.
Claims granted under the new patent cover
implantable three-dimensional scaffolds and brown adipocytes from
human brown adipose-derived stem cells. The combination of
scaffolds as a delivery system and brown adipose derived stem cells
provides the ability to deliver metabolically active cells.
Therapeutic benefits of using brown adipose have been demonstrated
in various models and may provide a valuable therapeutic tool for
treating a range of metabolic disorders.
“We continue to see success developing a
comprehensive global patent portfolio for ThermoStem® and this
latest notice of allowance further strengthens our overall IP
position in using scaffolds as a delivery system." said Lance
Alstodt, the Company’s CEO "The claims of this application are the
result of BioRestorative’s expertise in applying cell therapy to
treat metabolic disorders. They underscore the potential value of
ThermoStem® as a novel treatment for diseases such as diabetes and
obesity, which represent major unmet needs."
About BioRestorative
Therapies, Inc.
BioRestorative Therapies, Inc.
(www.biorestorative.com) develops therapeutic products using cell
and tissue protocols, primarily involving adult stem cells. Our two
core programs, as described below, relate to the treatment of
disc/spine disease and metabolic disorders:
• Disc/Spine Program (brtxDISC™): Our lead cell
therapy candidate, BRTX-100, is a product formulated from
autologous (or a person’s own) cultured mesenchymal stem cells
collected from the patient’s bone marrow. We intend that the
product will be used for the non-surgical treatment of painful
lumbosacral disc disorders or as a complementary therapeutic to a
surgical procedure. The BRTX-100 production process utilizes
proprietary technology and involves collecting a patient’s bone
marrow, isolating and culturing stem cells from the bone marrow and
cryopreserving the cells. In an outpatient procedure, BRTX-100 is
to be injected by a physician into the patient’s damaged disc. The
treatment is intended for patients whose pain has not been
alleviated by non-invasive procedures and who potentially face the
prospect of surgery. We have received authorization from the Food
and Drug Administration to commence a Phase 2 clinical trial using
BRTX-100 to treat chronic lower back pain arising from degenerative
disc disease.
• Metabolic Program (ThermoStem®): We are
developing a cell-based therapy candidate to target obesity and
metabolic disorders using brown adipose (fat) derived stem cells to
generate brown adipose tissue (“BAT”). BAT is intended to mimic
naturally occurring brown adipose depots that regulate metabolic
homeostasis in humans. Initial preclinical research indicates that
increased amounts of brown fat in animals may be responsible for
additional caloric burning as well as reduced glucose and lipid
levels. Researchers have found that people with higher levels of
brown fat may have a reduced risk for obesity and diabetes.
Forward-Looking Statements
This press release contains "forward-looking
statements" within the meaning of Section 27A of the Securities Act
of 1933, as amended, and Section 21E of the Securities Exchange Act
of 1934, as amended, and such forward-looking statements are made
pursuant to the safe harbor provisions of the Private Securities
Litigation Reform Act of 1995. You are cautioned that such
statements are subject to a multitude of risks and uncertainties
that could cause future circumstances, events or results to differ
materially from those projected in the forward-looking statements
as a result of various factors and other risks, including, without
limitation, those set forth in the Company's latest Form 10-K filed
with the Securities and Exchange Commission. You should consider
these factors in evaluating the forward-looking statements included
herein, and not place undue reliance on such statements. The
forward-looking statements in this release are made as of the date
hereof and the Company undertakes no obligation to update such
statements.
CONTACT:Email: ir@biorestorative.com
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