AFFX Affymetrix, Inc.

Affymetrix, Inc. (Nasdaq:AFFX) today announced that it will release results for the fourth quarter and fiscal year 2005 after close of the stock market on Thursday, January 26, 2006. Company management will also host a conference call at 2:00 p.m. PDT on January 26th to discuss fourth quarter and fiscal year 2005 results and provide financial guidance for the first quarter and fiscal year 2006. The dial-in number for domestic callers will be (866) 500-AFFX, international: (706) 643-2771. To listen to a live webcast of the conference call, please go to the "Investors" link in the "Resources for" drop-down menu at www.affymetrix.com. A replay of this call will be available from 5:00 p.m. PT on January 26, 2006 until 8:00 p.m. PT on February 2, 2006 at the following numbers: domestic: (800) 642-1687, international: (706) 645-9291. The passcode for both is 3859939. An archived webcast of the conference call will be available under the Investor Relations section of the Company's website at www.affymetrix.com. The conference call, replay and webcast are open to all interested parties. About Affymetrix: Affymetrix scientists invented the world's first high-density microarray in 1989 and began selling the first commercial microarray in 1994. Since then, Affymetrix GeneChip(R) technology has become the industry standard in molecular biology research. Affymetrix technology is used by the world's top pharmaceutical, diagnostic and biotechnology companies as well as leading academic, government and not-for-profit research institutes. More than 1,300 systems have been installed around the world and nearly 3,000 peer-reviewed papers have been published using the technology. Affymetrix' patented photolithographic manufacturing process provides the most information capacity available today on an array, enabling researchers to use a whole-genome approach to analyzing the relationship between genetics and health. Affymetrix is headquartered in Santa Clara, Calif., with manufacturing facilities in Sacramento, Calif., and Bedford, Mass. The company maintains important sales and marketing operations in Europe and Asia and has about 1,000 employees worldwide. For more information about Affymetrix, please visit the company's website at www.affymetrix.com.