Half-Year Review of Inventiva’s Liquidity Contract with Kepler Cheuvreux

Daix (France), Long Island City (New York, United States), January 30, 2023 – Inventiva (Euronext Paris and Nasdaq: IVA) (the “Company”), a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of patients with non-alcoholic steatohepatitis (NASH) and other diseases with significant unmet medical needs, today announced the half-year report of its liquidity contract with Kepler Cheuvreux.Under the liquidity contract granted to Kepler Cheuvreux by Inventiva, the following resources were available in the liquidity account as of December 31, 2022:

  • Cash: € 282,479.85
  • Number of shares: 113,003
  • Number of executions on buy side on semester: 541
  • Number of executions on sell side on semester: 491
  • Traded volume on buy side on semester: 116,853 shares for € 574,407.24
  • Traded volume on sell side on semester: 103,989 shares for € 540,127.34

At the last half-year report as of June 30, 2022, the following resources were available in the liquidity account:

  • Cash: € 316,759.75
  • Number of shares: 100,139
  • Number of executions on buy side on semester: 993
  • Number of executions on sell side on semester: 636
  • Traded volume on buy side on semester: 152,845 shares for € 1,470,441.72
  • Traded volume on sell side on semester: 98,168 shares for € 1,025,659.18

When the contract was initially implemented, the following resources were included in the liquidity account:

  • Cash: € 163,510.42
  • Number of shares: 34,063
  Buy Side   Sell Side
  Number of executions Number of shares Traded volume in EUR   Number of executions Number of shares Traded volume in EUR
Total 1534 269698 2 044 848,96   1127 202157 1 565 786,52
03/01/2022 8 1000 11 800,00   12 2471 29 553,16
04/01/2022 33 4501 53 336,85   11 2000 24 160,00
05/01/2022 20 1950 22 542,00   2 500 5 850,00
06/01/2022 3 49 563,50   - - -
07/01/2022 38 3187 36 013,10   - - -
10/01/2022 30 3999 43 709,07   - - -
11/01/2022 7 1000 10 680,00   13 2060 22 309,80
12/01/2022 12 2000 22 160,00   9 3440 38 872,00
13/01/2022 9 500 5 480,00   - - -
14/01/2022 5 1500 16 380,00   21 1614 17 931,54
17/01/2022 2 1000 10 980,00   7 639 7 099,29
19/01/2022 3 222 2 442,00   - - -
20/01/2022 1 1 11,20   19 3008 33 689,60
21/01/2022 8 1234 13 771,44   6 203 2 285,78
24/01/2022 30 5265 57 072,60   - - -
25/01/2022 1 1 10,54   - - -
26/01/2022 - - -   8 1500 16 125,00
27/01/2022 3 1000 10 680,00   5 500 5 400,00
28/01/2022 8 1319 14 179,25   17 2537 27 627,93
31/01/2022 15 1932 20 614,44   9 2000 21 560,00
01/02/2022 - - -   31 5500 61 105,00
02/02/2022 - - -   8 1000 11 800,00
03/02/2022 10 2000 22 720,00   11 827 9 436,07
04/02/2022 4 501 5 691,36   24 1565 17 966,20
07/02/2022 3 500 5 750,00   9 2000 23 340,00
08/02/2022 3 501 5 811,60   17 3000 35 580,00
09/02/2022 7 1501 17 666,77   16 1500 17 880,00
10/02/2022 - - -   1 50 598,00
11/02/2022 8 542 6 449,80   4 950 11 381,00
14/02/2022 27 4852 56 380,24   - - -
15/02/2022 4 500 5 530,00   - - -
16/02/2022 4 500 5 550,00   3 501 5 641,26
17/02/2022 25 2501 27 511,00   1 422 4 709,52
18/02/2022 4 1000 10 860,00   12 2185 23 947,60
21/02/2022 31 3546 38 119,50   - - -
22/02/2022 23 3648 37 428,48   5 755 7 776,50
23/02/2022 - - -   40 4245 44 827,20
24/02/2022 31 5306 53 272,24   2 155 1 612,00
  Buy Side   Sell Side
  Number of executions Number of shares Traded volume in EUR   Number of executions Number of shares Traded volume in EUR
Total 1534 269698 2 044 848,96   1127 202157 1 565 786,52
25/02/2022 - - -   36 4345 45 622,50
28/02/2022 4 500 5 250,00   7 3500 38 360,00
01/03/2022 6 1749 19 169,04   10 2109 23 768,43
02/03/2022 16 2548 27 696,76   - - -
03/03/2022 11 1842 19 506,78   - - -
04/03/2022 16 2058 21 403,20   - - -
07/03/2022 27 5430 52 671,00   10 2500 24 750,00
08/03/2022 5 1501 14 964,97   8 2501 25 760,30
09/03/2022 6 1000 9 950,00   2 548 5 540,28
10/03/2022 - - -   3 500 5 050,00
11/03/2022 6 1000 9 950,00   - - -
14/03/2022 4 1500 15 060,00   6 500 5 050,00
15/03/2022 17 2500 24 575,00   1 23 227,70
16/03/2022 6 500 5 000,00   11 1977 19 849,08
17/03/2022 8 1000 10 100,00   7 1452 14 955,60
18/03/2022 4 500 5 050,00   1 94 958,80
21/03/2022 4 1000 10 000,00   2 407 4 192,10
22/03/2022 5 251 2 530,08   14 1999 20 409,79
23/03/2022 3 500 5 150,00   2 500 5 200,00
24/03/2022 6 500 5 100,00   - - -
25/03/2022 12 926 9 454,46   2 260 2 678,00
28/03/2022 4 500 5 095,00   4 548 5 638,92
29/03/2022 2 501 5 110,20   14 2457 25 307,10
30/03/2022 3 311 3 234,40   3 495 5 148,00
31/03/2022 11 542 5 631,38   - - -
01/04/2022 8 1234 12 685,52   - - -
04/04/2022 5 598 6 099,60   6 1000 10 320,00
05/04/2022 1 228 2 325,60   2 500 5 150,00
06/04/2022 1 137 1 397,40   1 6 61,80
07/04/2022 3 500 5 100,00   3 170 1 751,00
08/04/2022 5 473 4 777,30   2 2 20,40
11/04/2022 1 485 4 898,50   8 998 10 179,60
12/04/2022 10 1000 10 150,00   3 867 8 886,75
13/04/2022 17 1599 15 910,05   - - -
14/04/2022 17 1500 14 655,00   1 100 990,00
19/04/2022 - - -   2 500 4 900,00
20/04/2022 1 1 9,70   20 1500 14 850,00
21/04/2022 2 6 59,28   6 500 5 000,00
  Buy Side   Sell Side
  Number of executions Number of shares Traded volume in EUR   Number of executions Number of shares Traded volume in EUR
Total 1534 269698 2 044 848,96   1127 202157 1 565 786,52
22/04/2022 5 495 4 900,50   - - -
25/04/2022 20 1782 17 231,94   1 7 69,30
26/04/2022 11 2401 22 425,34   - - -
27/04/2022 6 2005 17 984,85   - - -
28/04/2022 1 20 180,00   8 1250 11 400,00
29/04/2022 - - -   7 2000 18 500,00
02/05/2022 4 500 4 600,00   11 550 5 120,50
03/05/2022 3 150 1 392,00   - - -
05/05/2022 2 102 938,40   1 450 4 230,00
06/05/2022 6 898 8 315,48   - - -
09/05/2022 14 1980 17 919,00   - - -
11/05/2022 10 2544 22 387,20   9 1316 11 962,44
12/05/2022 10 1207 10 452,62   - - -
13/05/2022 6 678 5 810,46   2 802 7 009,48
16/05/2022 8 1291 10 973,50   - - -
17/05/2022 4 1012 8 551,40   7 1500 12 900,00
18/05/2022 - - -   9 1131 10 031,97
19/05/2022 - - -   5 619 5 614,33
20/05/2022 2 251 2 233,90   3 500 4 500,00
23/05/2022 3 1499 13 341,10   4 250 2 262,50
24/05/2022 4 275 2 420,00   1 500 4 450,00
25/05/2022 - - -   2 400 3 560,00
26/05/2022 1 500 4 450,00   3 500 4 500,00
27/05/2022 16 2488 21 645,60   - - -
30/05/2022 3 1000 8 550,00   1 1 8,80
31/05/2022 7 750 6 435,00   3 849 7 386,30
01/06/2022 - - -   4 500 4 300,00
02/06/2022 9 500 4 300,00   2 152 1 322,40
03/06/2022 15 1200 10 224,00   2 149 1 296,30
06/06/2022 3 600 5 100,00   1 1 8,60
07/06/2022 1 1 8,51   3 189 1 625,40
08/06/2022 4 150 1 282,50   4 411 3 538,71
09/06/2022 3 655 5 619,90   - - -
10/06/2022 8 845 7 233,20   3 500 4 350,00
13/06/2022 21 2488 20 501,12   - - -
14/06/2022 21 4100 32 267,00   - - -
15/06/2022 5 1500 11 220,00   - - -
16/06/2022 10 3000 21 540,00   - - -
  Buy Side   Sell Side
  Number of executions Number of shares Traded volume in EUR   Number of executions Number of shares Traded volume in EUR
Total 1534 269698 2 044 848,96   1127 202157 1 565 786,52
17/06/2022 3 1000 7 000,00   1 500 3 600,00
20/06/2022 7 1000 7 000,00   3 971 6 942,65
21/06/2022 1 500 3 550,00   3 180 1 299,60
22/06/2022 16 4500 30 375,00   1 500 3 500,00
23/06/2022 8 1000 6 650,00   - - -
24/06/2022 - - -   5 500 3 350,00
27/06/2022 10 2000 12 960,00   4 500 3 400,00
28/06/2022 7 2500 15 325,00   1 1 6,50
29/06/2022 18 6000 34 260,00   1 500 2 950,00
30/06/2022 - - -   1 4 22,80
01/07/2022 5 500 2 800,00   1 1 5,70
04/07/2022 - - -   10 3495 21 389,40
05/07/2022 - - -   6 622 3 806,64
06/07/2022 3 1000 5 950,00   1 1 6,25
07/07/2022 7 2500 14 400,00   1 1 6,00
08/07/2022 - - -   3 602 3 503,64
11/07/2022 10 1486 8 470,20   2 398 2 348,20
13/07/2022 3 514 2 878,40   - - -
14/07/2022 3 500 2 750,00   2 171 974,70
15/07/2022 3 501 2 705,40   1 1 5,44
18/07/2022 1 1 5,43   1 1 5,43
19/07/2022 7 1501 7 805,20   1 1 5,33
20/07/2022 1 500 2 500,00   4 500 2 600,00
21/07/2022 1 500 2 450,00   2 149 759,90
22/07/2022 1 1 4,92   3 352 1 795,20
26/07/2022 3 501 2 454,90   1 1 4,96
27/07/2022 1 1 4,91   1 1 4,91
28/07/2022 1 500 2 450,00   - - -
29/07/2022 3 1500 7 095,00   1 8 38,40
01/08/2022 1 500 2 350,00   6 492 2 361,60
02/08/2022 - - -   1 1 4,80
03/08/2022 1 135 621,00   - - -
04/08/2022 2 365 1 679,00   - - -
05/08/2022 3 501 2 304,60   2 44 206,80
08/08/2022 - - -   7 1456 6 988,80
09/08/2022 2 1000 4 680,00   3 1000 4 850,00
10/08/2022 - - -   5 750 3 615,00
11/08/2022 - - -   6 2500 12 600,00
  Buy Side   Sell Side
  Number of executions Number of shares Traded volume in EUR   Number of executions Number of shares Traded volume in EUR
Total 1534 269698 2 044 848,96   1127 202157 1 565 786,52
12/08/2022 - - -   5 2000 10 540,00
15/08/2022 1 500 2 600,00   2 500 2 700,00
16/08/2022 5 600 3 114,00   - - -
17/08/2022 7 1600 7 984,00   - - -
18/08/2022 1 1 4,96   1 1 4,96
19/08/2022 3 1000 4 850,00   2 500 2 520,00
22/08/2022 3 500 2 450,00   - - -
23/08/2022 4 501 2 404,80   2 2 9,80
24/08/2022 3 1001 4 754,75   5 499 2 445,10
25/08/2022 5 500 2 350,00   1 500 2 400,00
26/08/2022 3 501 2 354,70   1 346 1 660,80
29/08/2022 1 499 2 295,40   - - -
30/08/2022 - - -   7 1654 8 038,44
01/09/2022 3 1500 6 750,00   2 24 112,80
05/09/2022 1 500 2 190,00   - - -
06/09/2022 - - -   7 500 2 200,00
07/09/2022 9 1600 6 720,00   1 1 4,44
08/09/2022 1 1 4,16   2 131 556,75
09/09/2022 - - -   5 610 2 616,90
12/09/2022 3 500 2 100,00   2 10 43,00
13/09/2022 1 258 1 057,80   1 1 4,30
14/09/2022 3 501 2 004,00   1 1 4,11
15/09/2022 3 751 3 056,57   3 1000 4 100,00
16/09/2022 4 500 2 050,00   4 751 3 154,20
19/09/2022 3 749 3 010,98   2 500 2 150,00
21/09/2022 6 1000 4 030,00   - - -
22/09/2022 3 500 2 300,00   18 5474 25 837,28
23/09/2022 12 3550 15 407,00   - - -
26/09/2022 2 500 2 000,00   1 500 2 050,00
27/09/2022 2 750 3 000,00   3 250 1 012,50
28/09/2022 5 1250 4 925,00   - - -
29/09/2022 3 1500 5 700,00   1 2 8,00
30/09/2022 6 1500 5 475,00   - - -
03/10/2022 - - -   3 350 1 316,00
04/10/2022 - - -   7 1000 3 880,00
05/10/2022 4 1467 5 589,27   3 948 3 754,08
06/10/2022 - - -   25 6500 27 365,00
07/10/2022 1 500 2 300,00   23 4566 21 505,86
  Buy Side   Sell Side
  Number of executions Number of shares Traded volume in EUR   Number of executions Number of shares Traded volume in EUR
Total 1534 269698 2 044 848,96   1127 202157 1 565 786,52
10/10/2022 5 1000 6 350,00   34 10761 69 731,28
11/10/2022 32 6500 39 975,00   18 4100 28 946,00
12/10/2022 14 3000 17 250,00   4 1320 7 774,80
13/10/2022 10 3000 16 140,00   - - -
14/10/2022 2 500 2 800,00   18 4500 25 785,00
17/10/2022 - - -   26 5997 38 500,74
18/10/2022 12 3000 18 750,00   5 701 4 836,90
19/10/2022 15 2500 15 100,00   - - -
20/10/2022 3 501 3 056,10   6 2500 15 500,00
21/10/2022 14 1499 8 994,00   - - -
24/10/2022 4 1500 9 000,00   5 530 3 264,80
25/10/2022 10 2100 12 096,00   7 770 4 604,60
26/10/2022 - - -   16 2000 11 700,00
27/10/2022 7 1000 6 050,00   4 1500 9 180,00
28/10/2022 12 3001 17 765,92   3 501 3 056,10
31/10/2022 51 13500 68 580,00   - - -
01/11/2022 2 500 2 325,00   2 500 2 400,00
03/11/2022 8 3650 16 498,00   - - -
04/11/2022 6 1000 4 500,00   1 500 2 300,00
07/11/2022 9 1800 7 884,00   - - -
08/11/2022 7 1500 6 390,00   2 750 3 240,00
09/11/2022 4 1000 4 330,00   - - -
10/11/2022 13 1700 7 021,00   3 1000 4 180,00
11/11/2022 - - -   5 990 4 257,00
14/11/2022 - - -   9 2110 9 537,20
15/11/2022 15 2851 12 401,85   1 1 4,49
16/11/2022 7 1000 4 250,00   1 250 1 070,00
17/11/2022 4 500 2 150,00   4 1250 5 437,50
18/11/2022 8 1351 5 741,75   3 401 1 724,30
21/11/2022 5 1000 4 150,00   - - -
22/11/2022 10 1750 7 017,50   1 500 2 100,00
23/11/2022 3 1500 5 955,00   4 750 3 015,00
24/11/2022 - - -   1 500 2 000,00
25/11/2022 4 1000 4 000,00   3 750 3 015,00
28/11/2022 2 500 2 000,00   8 1000 4 080,00
29/11/2022 3 750 3 240,00   17 3750 16 425,00
30/11/2022 3 1000 4 250,00   - - -
17/11/2022 4 500 2 150,00   4 1250 5 437,50
  Buy Side   Sell Side
  Number of executions Number of shares Traded volume in EUR   Number of executions Number of shares Traded volume in EUR
Total 1534 269698 2 044 848,96   1127 202157 1 565 786,52
18/11/2022 8 1351 5 741,75   3 401 1 724,30
21/11/2022 5 1000 4 150,00   - - -
22/11/2022 10 1750 7 017,50   1 500 2 100,00
23/11/2022 3 1500 5 955,00   4 750 3 015,00
24/11/2022 - - -   1 500 2 000,00
25/11/2022 4 1000 4 000,00   3 750 3 015,00
28/11/2022 2 500 2 000,00   8 1000 4 080,00
29/11/2022 3 750 3 240,00   17 3750 16 425,00
30/11/2022 3 1000 4 250,00   - - -
05/12/2022 - - -   3 598 2 583,36
06/12/2022 4 701 3 007,29   6 701 3 021,31
07/12/2022 12 1750 7 367,50   - - -
08/12/2022 4 751 3 094,12   1 1 4,18
09/12/2022 1 1 4,09   2 40 166,00
12/12/2022 6 850 3 468,00   1 1 4,15
13/12/2022 1 1 4,07   6 1211 5 025,65
14/12/2022 - - -   3 258 1 083,60
15/12/2022 11 1001 4 104,10   1 1 4,18
16/12/2022 3 251 1 016,55   2 201 818,07
19/12/2022 4 255 1 032,75   15 3944 16 880,32
20/12/2022 8 750 3 232,50   1 180 783,00
21/12/2022 2 500 2 150,00   3 250 1 080,00
22/12/2022 2 1000 4 280,00   10 1250 5 462,50
23/12/2022 1 1 4,40   7 1501 6 679,45
28/12/2022 3 501 2 204,40   1 1 4,44
29/12/2022 - - -   7 2000 8 980,00
30/12/2022 2 500 2 235,00   - - -

About Inventiva

Inventiva is a clinical-stage biopharmaceutical company focused on the research and development of oral small molecule therapies for the treatment of patients with NASH, mucopolysaccharidoses (MPS) and other diseases with significant unmet medical needs. The Company benefits from a strong expertise and experience in the domain of compounds targeting nuclear receptors, transcription factors and epigenetic modulation. Inventiva is currently advancing one clinical candidate, has a pipeline of two preclinical programs and continues to explore other development opportunities to add to its pipeline.

Inventiva’s lead product candidate, lanifibranor, is currently in a pivotal Phase III clinical trial, NATiV3, for the treatment of adult patients with NASH, a common and progressive chronic liver disease for which there are currently no approved therapies. In 2020, Inventiva reported positive results from its Phase IIb clinical trial evaluating lanifibranor for the treatment of patients with NASH and received Breakthrough Therapy and Fast Track status from the U.S. Food and Drug Administration (“FDA”) for lanifibranor in the treatment of NASH.

Inventiva’s pipeline also includes odiparcil, a drug candidate for the treatment of adult MPS VI patients. As part of Inventiva’s decision to focus clinical efforts on the development of lanifibranor, it suspended its clinical efforts relating to odiparcil and is reviewing available options with respect to its potential further development. Inventiva is in the process of selecting an oncology development candidate for its Hippo signaling pathway program.

The Company has a scientific team of approximately 80 people with deep expertise in the fields of biology, medicinal and computational chemistry, pharmacokinetics and pharmacology, and clinical development. It owns an extensive library of approximately 240,000 pharmacologically relevant molecules, approximately 60% of which are proprietary, as well as a wholly-owned research and development facility.

Inventiva is a public company listed on compartment C of the regulated market of Euronext Paris (ticker: IVA - ISIN: FR0013233012) and on the Nasdaq Global Market in the United States (ticker: IVA). www.inventivapharma.com.

Contacts

Inventiva Pascaline Clerc VP of Global External Affairs media@inventivapharma.com   +1 240 620 9175 Brunswick Group Tristan Roquet Montegon / Aude Lepreux / Matthieu Benoist Media relations inventiva@brunswickgroup.com    +33 1 53 96 83 83 Westwicke, an ICR Company Patricia L. Bank Investor relations patti.bank@westwicke.com           +1 415 513-1284            

Important Notice

This press release contains “forward-looking statements” within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release are forward-looking statements. These statements include, but are not limited to, expectations with respect to the pivotal Phase III clinical trial evaluating lanifibranor in patients with NASH, including recruitment of patients for that trial, the Company’s ability to satisfy conditions precedent to draw down on the second tranche under the EIB facility, potential future financings or strategic transactions, milestone payments and royalties, the Company’s ability to exercise its rights under the EIB facility, including its call right and right of first refusal, expectations with respect to EIB’s rights under the EIB facility and EIB’s potential exercise of warrants, the expected use of proceeds from the EIB facility, and the sufficiency of Inventiva’s cash resources and cash runway. Certain of these statements, forecasts and estimates can be recognized by the use of words such as, without limitation, “believes”, “anticipates”, “expects”, “intends”, “plans”, “seeks”, “estimates”, “may”, “will”, “would”, “could”, “might”, “should”, and “continue” and similar expressions. Such statements are not historical facts but rather are statements of future expectations and other forward-looking statements that are based on management's beliefs. These statements reflect such views and assumptions prevailing as of the date of the statements and involve known and unknown risks and uncertainties that could cause future results, performance or future events to differ materially from those expressed or implied in such statements. Future events are difficult to predict and may depend upon factors that are beyond Inventiva's control. There can be no guarantees with respect to pipeline product candidates that the clinical trial results will be available on their anticipated timeline, that future clinical trials will be initiated as anticipated, that product candidates will receive the necessary regulatory approvals. Actual results may turn out to be materially different from the anticipated future results, performance or achievements expressed or implied by such statements, forecasts and estimates, due to a number of factors, including that Inventiva is a clinical-stage company with no approved products and no historical product revenues, Inventiva has incurred significant losses since inception, Inventiva has a limited operating history and has never generated any revenue from product sales, Inventiva will require additional capital to finance its operations, Inventiva's future success is dependent on the successful clinical development, regulatory approval and subsequent commercialization of current and any future product candidates, preclinical studies or earlier clinical trials are not necessarily predictive of future results and the results of Inventiva's clinical trials may not support Inventiva's product candidate claims, Inventiva may encounter substantial delays in its clinical trials or Inventiva may fail to demonstrate safety and efficacy to the satisfaction of applicable regulatory authorities, enrolment and retention of patients in clinical trials is an expensive and time-consuming process and could be made more difficult or rendered impossible by multiple factors outside Inventiva's control, Inventiva's product candidates may cause adverse drug reactions or have other properties that could delay or prevent their regulatory approval, or limit their commercial potential, Inventiva faces substantial competition and Inventiva’s business, and preclinical studies and clinical development programs and timelines, its financial condition and results of operations could be materially and adversely affected by the current COVID-19 pandemic and geopolitical events, such as the conflict between Russia and Ukraine, related sanctions and related impacts and potential impacts on the initiation, enrolment and completion of Inventiva’s clinical trials on anticipated timelines and macroeconomic conditions, including global inflation and uncertain financial markets or at all. Given these risks and uncertainties, no representations are made as to the accuracy or fairness of such forward-looking statements, forecasts and estimates. Furthermore, forward-looking statements, forecasts and estimates only speak as of the date of this press release. Readers are cautioned not to place undue reliance on any of these forward-looking statements.

Please refer to the Universal Registration Document for the year ended December 31, 2021 filed with the Autorité des Marchés Financiers on March 11, 2022, the Annual Report on Form 20-F for the year ended December 31, 2021 filed with the Securities and Exchange Commission on March 11, 2022 and the financial report for the first half of 2022 filed with the Securities and Exchange Commission on September 22, 2022 for additional information in relation to such factors, risks and uncertainties.

All information in this press release is as of the date of the release. Except as required by law, Inventiva has no intention and is under no obligation to update or review the forward-looking statements referred to above.

 

Attachment

  • Inventiva - PR - Liquidity contract - H2 22 - EN - 01 30 2023
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