Biovest International, Inc. (OTCQB: BVTI), a majority-owned subsidiary of Accentia Biopharmaceuticals, Inc. (OTCQB: ABPI), today announced that an article was published in Drug Discovery News, reporting on the promise of Biovest’s BiovaxID® personalized cancer vaccine for the treatment of non-Hodgkin’s lymphoma, an incurable form of blood cancer.

The article, titled “Just a Shot in the Dark?”, reports that, “A drug of great promise on the horizon is BiovaxID, Biovest’s late-stage personalized cancer vaccine for the treatment of non-Hodgkin’s lymphoma. If approved, BiovaxID would represent the first non-immunosuppressive consolidation therapy option for patients with follicular lymphoma. Biovest has on its medical board Dr. Larry Kwak of the University of Texas MD Anderson Cancer Center, who was recognized by Time Magazine as a 2010 Person of the Year for his decade of work in the area of cancer vaccines.”

The article also includes an interview with Biovest’s clinical advisor, Sattva S. Neelapu, M.D., Associate Professor, Department of Lymphoma/Myeloma, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center.

Dr. Neelapu states, “BiovaxID induces both antibody and T-cell responses against the idiotype (Id), which is the tumor-specific antigen expressed on B-cell lymphomas such as follicular lymphoma. Antibodies induced by the vaccine can bind to the Id expressed on tumor cells and mediate killing via other immune cells. T-cells induced by the vaccine also recognize Id-derived peptides on the tumor and mediate killing by secreting various cytokines and other cytotoxic molecules. Our results suggest that the T-cell responses are likely to be more important than antibody responses for BiovaxID's effect.”

Based on positive outcomes from three BiovaxID clinical trials, including a multi-center, controlled, randomized Phase III follicular lymphoma study, Biovest is currently in the process of conducting a series of clinical pre-filing meetings including with Health Canada, the EMA, individual EU national agencies, and the FDA. The guidance and recommendations received at these meetings will determine the next steps in seeking approvals for BiovaxID.

The complete Drug Discovery News article can be accessed in the Media Center at Biovest's corporate website at: http://www.biovest.com/investor-relations/media-center

About BiovaxID®

Biovest's lead drug product is BiovaxID®, an autologous active immunotherapy (personalized cancer vaccine) for the treatment of certain B-cell subtypes of non-Hodgkin's lymphoma, an incurable form of blood cancer. Over the past decade, two Phase II clinical trials and a Phase III clinical trial have demonstrated strong and cumulative evidence with regards to BiovaxID vaccination’s safety and efficacy. With regards to safety, all clinical trials to date demonstrate that BiovaxID vaccination is highly safe and poses a nearly vanishingly small toxicity risk relative to approved anti-lymphoma agents. Moreover, BiovaxID provides substantial and durable clinical efficacy with the Phase III clinical trial demonstrating that BiovaxID significantly improves disease-free survival in follicular lymphoma and the Phase II mantle cell lymphoma clinical trial demonstrating that BiovaxID induces strong idiotype-specific T-cell responses which strongly correlate with highly-statistically significant overall survival.

About Biovest International, Inc.

Biovest International, Inc. is an emerging leader in the field of active personalized immunotherapies. In collaboration with the National Cancer Institute, Biovest has developed a patient-specific, cancer vaccine, BiovaxID®, with three clinical trials completed, including a Phase III study, demonstrating evidence of safety and efficacy for the treatment of indolent follicular non-Hodgkin’s lymphoma.

Headquartered in Tampa, Florida with its bio-manufacturing facility based in Minneapolis, Minnesota, Biovest is publicly-traded on the OTCQB™ Market with the stock-ticker symbol “BVTI”, and is a majority-owned subsidiary of Accentia Biopharmaceuticals, Inc. (OTCQB: “ABPI”).

For further information, please visit: http://www.biovest.com

Forward-Looking Statements:

Statements in this release that are not strictly historical in nature constitute "forward-looking statements." Such statements include, but are not limited to statements about BiovaxID®, AutovaxID®, events occurring after dates hereof, and any other statements relating to products, product candidates, product development programs, the FDA or clinical study process including the commencement, process, or completion of clinical trials or the regulatory process. Such statements may include, without limitation, statements with respect to the Company's plans, objectives, expectations and intentions, and other statements identified by words such as "may," "could," "would," "should," "believes," "expects," "anticipates," "estimates," "intends," "plans," or similar expressions. Such forward-looking statements involve known and unknown risks, uncertainties, and other factors that may cause the actual results of Biovest to be materially different from historical results or from any results expressed or implied by such forward-looking statements. These factors include, but are not limited to, risks and uncertainties related to the progress, timing, cost, and results of clinical trials and product development programs; difficulties or delays in obtaining regulatory approval for product candidates; competition from other pharmaceutical or biotechnology companies; and the additional risks discussed in filings with the Securities and Exchange Commission. All forward-looking statements are qualified in their entirety by this cautionary statement, and Biovest undertakes no obligation to revise or update this news release to reflect events or circumstances after the date hereof. The product names used in this statement are for identification purposes only. All trademarks and registered trademarks are the property of their respective owners.