Post-effective Amendment (investment Company, Rule 485(b)) (485bpos)

As filed with the Securities and Exchange Commission on March 22, 2013

File Nos. 002-11387/811-00558

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-1A

	REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933	/ X /

	Pre-Effective Amendment No.	/ /
	Post-Effective Amendment No. 121	/ X /

	and/or

	REGISTRATION STATEMENT UNDER THE
	INVESTMENT COMPANY ACT OF 1940	/ X /

	Amendment No.	/ X /

THE HARTFORD MUTUAL FUNDS II, INC.

(Exact Name of Registrant as Specified in Charter)

P. O. Box 2999, Hartford, Connecticut 06104-2999

(Address of Principal Executive Offices)

Registrant's Telephone Number, including Area Code: (860) 843-9934

Edward P. Macdonald, Esquire

The Hartford Financial Services Group, Inc.

Life Law – Mutual Funds Unit

200 Hopmeadow Street

Simsbury, Connecticut 06089

(Name and Address of Agent for Service)

Copy to:

John V. O’Hanlon, Esquire

Dechert LLP

200 Clarendon Street, 27 ^th Floor

Boston, Massachusetts 02116-5021

It is proposed that this filing will become effective (check appropriate box):

	X	immediately upon filing pursuant to paragraph (b) of Rule 485
		on (Date) pursuant to paragraph (b) of Rule 485
		60 days after filing pursuant to paragraph (a)(1) of Rule 485
		on (Date) pursuant to paragraph (a)(1) of Rule 485
		75 days after filing pursuant to paragraph (a)(2) of Rule 485
		on (Date) pursuant to paragraph (a)(2) of Rule 485

If appropriate, check the following box:

This post-effective amendment designates a new effective date for a previously filed post-effective amendment.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933 and the Investment Company Act of 1940, the Registrant certifies that it meets all of the requirements for effectiveness of this Registration Statement under rule 485b under the Securities Act of 1933 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Hartford, State of Connecticut, on the 22 ^nd day of March 2013.

	THE HARTFORD MUTUAL FUNDS II, INC.


	By:	/s/ James E. Davey
		James E. Davey
		Its: President

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities and on the date indicated.

Signature	Title	Date

/s/ James E. Davey	President,	March 22, 2013
James E. Davey	Chief Executive Officer

/s/ Mark A. Annoni	Controller & Treasurer	March 22, 2013
Mark A. Annoni	(Chief Accounting Officer &
	Chief Financial Officer)

*	Director	March 22, 2013
Lynn S. Birdsong

*	Chairman of the Board	March 22, 2013
Robert M. Gavin, Jr.	and Director

*	Director	March 22, 2013
Duane E. Hill

*	Director	March 22, 2013
Sandra S. Jaffee

*	Director	March 22, 2013
William P. Johnston

*	Director	March 22, 2013
Phillip O. Peterson

*	Director	March 22, 2013
Lemma W. Senbet

*	Director	March 22, 2013
Lowndes A. Smith

/s/ Edward P. Macdonald		March 22, 2013
* By Edward P. Macdonald
Attorney-in-fact

* Pursuant to Power of Attorney dated February 6, 2013 (incorporated by reference to Post-Effective Amendment No. 120 to Registration Statement on Form N-1A (File No. 002-11387) filed on February 28, 2013).

EXHIBIT INDEX

Exhibit No.

EX-101.INX	XBRL Instance Document

EX-101.SCH	XBRL Taxonomy Extension Schema Document

EX-101.CAL	XBRL Taxonomy Extension Calculation Linkbase Document

EX-101.DEF	XBRL Taxonomy Extension Definition Linkbase Document

EX-101.LAB	`XBRL Taxonomy Extension Labels Linkbase Document

EX-101.PRE	XBRL Taxonomy Extension Presentation Linkbase Document