- Amended Statement of Changes in Beneficial Ownership (4/A)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Expires: February 28, 2011 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* MITCHELL DANIEL J	2. Issuer Name and Ticker or Trading Symbol REPLIDYNE INC [ RDYN ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) SEQUEL VENTURE PARTNERS, L.L.C., 4430 ARAPAHOE AVENUE, SUITE 220	3. Date of Earliest Transaction (MM/DD/YYYY) 12/2/2008
(Street) BOULDER, CO 80303 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY) 12/4/2008	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	12/2/2008		P		100	A	$.58	16771	I	By The Daniel J. Mitchell Trust
Common Stock	12/2/2008		P		4495	A	$.60	21266	I	By The Daniel J. Mitchell Trust
Common Stock	12/2/2008		P		5100	A	$.62	26366	I	By The Daniel J. Mitchell Trust
Common Stock	12/2/2008		P		13000	A	$.6201	39366	I	By The Daniel J. Mitchell Trust
Common Stock	12/3/2008		P		400	A	$.64	39766	I	By The Daniel J. Mitchell Trust
Common Stock	12/3/2008		P		1000	A	$.65	40766	I	By The Daniel J. Mitchell Trust
Common Stock	12/3/2008		P		15100	A	$.66	55866	I	By The Daniel J. Mitchell Trust
Common Stock	12/3/2008		P		1600	A	$.67	57466	I	By The Daniel J. Mitchell Trust
Common Stock	12/3/2008		P		1100	A	$.69	58566	I	By The Daniel J. Mitchell Trust
Common Stock	12/3/2008		P		800	A	$.70	59366	I	By The Daniel J. Mitchell Trust
Common Stock								1412065	I	By Sequel Limited Partnership III ⁽¹⁾
Common Stock								39240	I	By Sequel Entrepreneurs' Fund III, L.P. ⁽¹⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:

( 1)

The Reporting Person is a manager of Sequel Venture Partners III, L.L.C., the general partner of Sequel Limited Partnership III ("SLP III") and Sequel Entrepreneurs' Fund III, L.P. ("SEF III"). As such, the Reporting Person shares voting and investment power over the shares held by SLP III and SEF III and may be deemed to have indirect beneficial ownership of such shares. The Reporting Person disclaims beneficial ownership of such shares held by SLP III and SEF III except to his proportionate pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
MITCHELL DANIEL J SEQUEL VENTURE PARTNERS, L.L.C. 4430 ARAPAHOE AVENUE, SUITE 220 BOULDER, CO 80303	X

Signatures
/s/ Laura M. Medina, Attorney-in-Fact		12/19/2008
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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