TIDMVRP 
 
THIS ANNOUNCEMENT IS NOT FOR PUBLICATION, RELEASE OR DISTRIBUTION, DIRECTLY OR 
INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO OR FROM THE UNITED STATES, 
AUSTRALIA, CANADA, THE REPUBLIC OF SOUTH AFRICA OR JAPAN OR ANY OTHER 
JURISDICTION IN WHICH SUCH PUBLICATION, RELEASE OR DISTRIBUTION WOULD BE 
UNLAWFUL. THIS ANNOUNCEMENT IS FOR INFORMATION PURPOSES ONLY AND DOES NOT 
CONSTITUTE AN OFFER OR AN INVITATION TO ACQUIRE OR DISPOSE OF ANY SECURITIES. 
 
                               Verona Pharma plc 
 
                      ("Verona Pharma" or the "Company") 
 
                          Admission of Placing Shares 
 
                              Total Voting Rights 
 
                              Directors' Holdings 
 
                       Warrant Shares and Block Listing 
 
29 July 2016, Cardiff - Further to the announcement of its proposed Placing on 
17 June 2016 and the announcement of shareholder approval for the Placing at a 
General Meeting (GM) held on 22 July 2016, Verona Pharma plc (AIM: VRP), the 
drug development company focused on first-in-class medicines to treat 
respiratory diseases, is pleased to confirm that, following admission to 
trading of the Placing Shares on AIM with effect from 8.00 a.m. BST, the 
Placing is now unconditional. 
 
Highlights 
 
  * The Placing has secured funding to raise gross proceeds of GBP44.7 million 
    (approximately US$63.3 million at the exchange rate of 17 June 2016). 
 
  * The net proceeds of the Placing of approximately GBP41.9 million will be used 
    as follows: 
 
      + predominantly to progress its lead candidate, RPL554, through a Phase 
        2b clinical trial in COPD patients; 
 
      + to fund additional clinical Phase 2 studies in COPD and cystic 
        fibrosis; 
 
      + to fund further supportive pre-clinical work, including the development 
        of a dry powder inhaler (DPI) or metered dose inhaler (MDI); and 
 
      + for general working capital purposes. 
 
  * The Board anticipates that, with additional funds successfully obtained and 
    deployed as described above, RPL554 will continue to progress through what 
    are expected to be further significant value inflection points. 
 
  * The Board is now evaluating its drug development plans and looks forward to 
    providing the Company's enlarged shareholder base with further updates in 
    due course 
 
    Total Voting Rights 
 
Pursuant to the oversubscribed Placing, the Company has issued 1,555,796,345 
Units to new and existing investors at the Placing Price of 2.873 pence per 
Unit. Each Unit comprises one Placing Share and one Warrant (with an 
entitlement to subscribe for 0.4 of an Ordinary Share at a per share exercise 
price of 120% of the Placing Price or 3.4476 pence). 
 
Following Admission, the number of Ordinary Shares in issue and the number of 
voting rights following Admission of the Placing Shares is 2,565,719,826. This 
figure may be used by Shareholders as the denominator for the calculations by 
which they will determine whether they are required to notify their interest 
in, or a change to their interest in, the Company under the FCA's Disclosure 
and Transparency Rules. 
 
Directors' Holdings 
 
As part of the Placing, Dr. David Ebsworth, Non-Executive Chairman of the 
Company, purchased a further 614,455 Ordinary Shares via his purchase of the 
same number of Units. Following Admission and Dr. Ebsworth's participation in 
the Placing, the Company confirms that the Directors of the Company now hold 
the following interests in the issued share capital of the Company: 
 
                                          Number of            Percentage of 
                                    Ordinary Shares   Enlarged Share Capital 
 
Dr. Jan-Anders Karlsson                   2,870,000                    0.11% 
(CEO) 
 
Dr. David Ebsworth                        5,214,227                    0.20% 
(Chairman) 
 
Additional information relating to the Warrant Shares, the Company's Block 
Listing and its prospective US IPO is contained below. 
 
Defined terms used in this announcement shall have the same meaning as those 
terms defined and used in the Circular dated 17 June 2016. 
 
For further information please contact: 
 
 Verona Pharma plc                     Tel: +44 (0)20 3283 4200 
 
 Jan-Anders Karlsson, Chief Executive 
Officer 
 
 N+1 Singer (Nominated Adviser and     Tel: +44 (0)20 7496 3000 
Broker) 
 
 Aubrey Powell / Jen Boorer 
 
 FTI Consulting                        Tel: +44 (0)20 3727 1000 
 
 Simon Conway/Stephanie Cuthbert 
 
IMPORTANT NOTICE 
 
The Circular is not an offer of securities for sale in the United States. The 
securities being offered by the Company may not be offered or sold in the 
United States absent registration or an exemption from registration. The 
offering of securities described in the Circular has not been and will not be 
registered under the United States Securities Act of 1933, and accordingly, any 
offer or sale of the securities may be made only in a transaction exempt from 
the registration requirements of the Securities Act. 
 
Notes to Editors 
 
About Verona Pharma plc 
 
Verona Pharma plc is a UK-based clinical stage biopharmaceutical company 
focused on the development of innovative prescription medicines to treat 
respiratory diseases with significant unmet medical needs, such as chronic 
obstructive pulmonary disease (COPD), asthma and cystic fibrosis. 
 
Verona Pharma's lead drug, RPL554, is a first-in-class drug currently in phase 
II trials as a nebulised maintenance treatment for COPD patients with moderate 
to severe disease and possibly as a treatment of acute exacerbations of COPD in 
the hospital setting. The drug is a dual phosphodiesterase (PDE) 3/4 inhibitor 
and therefore has both bronchodilator and anti-inflammatory effects, which are 
essential to the improvement of patients with COPD and asthma. 
 
Verona Pharma is also building a broader portfolio of RPL554-containing 
products to maximise its benefit to patients and its value. This includes the 
very significant markets for COPD and asthma maintenance therapy. The Company 
is also exploring the potential of the drug in different diseases, such as 
cystic fibrosis, where it is in pre-clinical testing and has recently received 
a Venture and Innovation Award from the Cystic Fibrosis Trust. 
 
About Chronic Obstructive Pulmonary Disease (COPD) 
 
Sixty-five million people worldwide suffer from moderate to severe COPD and the 
World Health Organisation (WHO) expects COPD to be the 3rd leading cause of 
death globally by 2020. It is the only major chronic disease with increasing 
mortality. Currently available drugs are aimed at long-term maintenance 
therapy, with the market dominated by large pharma. Despite the wide 
availability of these therapies, COPD patients suffer acute periods of 
worsening symptoms (exacerbations), which cause, in the US alone, some 1.5 
million A&E visits, 726,000 hospitalisations and 120,000 deaths per annum. 
 
Bronchodilator therapy is considered to be the standard of care, and agents can 
be administered via handheld devices such as metered dose inhaler (MDI), dry 
powder inhaler (DPI) and by nebulisers. The nebulised bronchodilator market was 
worth about $1 billion in 2014 in the US1. RPL554 is being developed by Verona 
Pharma as an add-on therapy to the "Standard of Care" with the objectives of 
providing rapid and pronounced improvement in lung function, reduced symptoms 
and both shortened duration of hospital stays and reduced re-admission rates 30 
days after discharge from hospital. Studies to date on RPL554 have demonstrated 
that it has a strongly differentiated 3-way mode of action, being: (1) 
bronchodilation (the relaxation of smooth muscle in the airway); (2) 
anti-inflammatory effects on cells and (3) ion channel activation in epithelial 
cells, with increased mucociliary clearance of the airway. 
 
1 IMS Consulting Group market research 2014 
 
ADDITIONAL INFORMATION 
 
Warrant Shares 
 
At the recent GM, the Company obtained full authority from Shareholders to 
issue and allot up to 622,318,538 Warrant Shares, being the maximum possible 
number of further new Ordinary Shares which may arise following the valid 
exercise of Warrants in due course. 
 
None of the Warrant Shares are included in the Total Voting Rights figure 
above. For the avoidance of doubt, the Warrants themselves will not be 
separately admitted to trading on AIM, but any Warrant Shares issued and 
allotted following the valid exercise of Warrants will become part of the 
single class of Ordinary Shares admitted to trading on AIM and will rank pari 
passu with all other Ordinary Shares. 
 
The Warrants are capable of exercise on the earlier of the Company's planned US 
IPO or the anniversary of Admission of the Placing Shares, and the exercise 
period shall end on the fifth anniversary of such date. In the event that the 
Company announces a definitive agreement providing for an Acquisition prior to 
the closing of Tranche 2, the exercise period shall instead begin immediately 
following such announcement but still end as above. 
 
The Warrants may be exercised either in cash or on a cashless exercise basis, 
whereby the Warrantholder will forgo such number of Warrant Shares as represent 
at the relevant time the value of the cost of exercise, and receive bonus 
shares equal to the Warrantholder's net entitlement. Shareholders should note 
that the net number of Warrant Shares to be received in connection with a 
cashless exercise of Warrants will be determined by the future price of the 
Company's Shares. Warrantholders must also be Shareholders in order to be able 
to exercise any of their Warrants on a cashless exercise basis. 
 
The maximum number of Warrant Shares above assumes that all Warrants are 
exercised on a 'for cash' basis. The number of Warrant Shares arising will be 
lower than the maximum possible if the cashless exercise mechanism is used by 
any Warrantholders (as is described in more detail in paragraph 5 of part I and 
paragraph 4.4 of part III of the Circular). 
 
If Tranche 2 is completed within a year after Tranche 1, to the extent that any 
Placee does not fully subscribe for an equivalent value of Ordinary Shares or 
ADSs in Tranche 2 (including the value of any Ordinary Shares or ADSs acquired 
in any concurrent Exempt Placement made on substantially the same terms as the 
US IPO) as subscribed for in Tranche 1, subject to allocations in Tranche 2 
being potentially adjusted downwards by the underwriter in connection with the 
US IPO, such Placee will (subject to certain limited exceptional circumstances) 
forfeit any Warrants issued to it in Tranche 1. However, if the Placee's 
allocation is reduced by the managing underwriter in the US IPO, then the 
required level of participation to retain the Warrants in full shall be only 
that amount that is allocated to the Placee in Tranche 2. 
 
Given the potential cashless exercise mechanism of the Warrants (and also the 
possible forfeiture of Warrants as described above), it is likely, in the 
Company's reasonably held opinion, that the number of Warrant Shares to be 
issued following the exercise of Warrants over time will be materially lower 
than the maximum number possible. 
 
Block Listing 
 
Based on the application to the London Stock Exchange for a block admission of 
Warrant Shares, the Company has been granted a block listing over a total of up 
to 513,143,965 Ordinary Shares. The Company expects to apply for extensions to 
the block listing for the purpose of issuing additional Warrant Shares from 
time to time, as appropriate. Verona Pharma retains full authority to issue and 
allot new Ordinary Shares to satisfy the exercise of Warrants in full. 
 
Tranche 2 (US IPO) 
 
Pursuant to the Purchase Agreement, the Company has agreed to use its 
commercially reasonable efforts to complete a firm commitment registered public 
offering of ADSs in the United States with an aggregate offering size 
reasonably acceptable to the Company and to the holders of a majority of the 
Units issued in the Placing, coupled with a listing of such ADSs on NASDAQ. The 
Company has agreed to use its commercially reasonable efforts to consummate the 
US IPO as promptly as possible and no later than 180 days following Admission, 
or by such later date as may be agreed by the Company and Placees holding a 
majority of the US Units issued in the US Placing. We refer to the US IPO and 
the concurrent Exempt Placement as 'Tranche 2'. Following the US IPO and as 
requested by Placees, New Shares held by such Placees may be converted into 
ADSs (subject to any limitations under United States securities laws). The 
Company will pay the reasonable expenses of the Placees in respect of the 
conversion of New Shares issued in connection with the Placing into ADSs (to 
the extent required) at the appropriate time. 
 
It is expected that the Company's entire share capital will remain admitted to 
trading on AIM following the US IPO. Any such transaction will require separate 
approval by Shareholders. While the Company has agreed to use its commercially 
reasonable efforts to facilitate the US IPO, there is no certainty that the US 
IPO will proceed as targeted, or at all. Additional information in respect of 
the prospective US IPO is set out in part II of the Circular. 
 
The ADSs will be negotiable instruments, representing ownership of Ordinary 
Shares. They are designed to facilitate the purchase, holding and sale of 
Ordinary Shares by US investors. Each of the offered ADSs will represent an 
exact number of Ordinary Shares. This number will be determined by the 
Directors during the offering process. 
 
 
 
END 
 

(END) Dow Jones Newswires

July 29, 2016 03:06 ET (07:06 GMT)

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