VRP Verona Pharma Plc

 
TIDMVRP 
 
Verona Pharma plc 
 
                      ("Verona Pharma" or the "Company") 
 
                    Trading and Development Programme Update 
 
             Solid progress leads to acceleration of RPL554 trials 
 
3 March 2015, Cardiff - Verona Pharma plc (AIM: VRP.L), the drug development 
company focused on first-in-class medicines to treat respiratory diseases, 
today announces a trading update for the year ended 31 December 2014, as well 
as an update on the Company's development programme for its lead drug, RPL554. 
It is expected that financial results for the year ended 31 December 2014 will 
be published during the first week of May. 
 
The closing cash position at year end was GBP9.97m, in line with market 
expectations. The Board continues to believe that this is sufficient capital to 
progress RPL554 to the start of Phase IIb clinical trials in 2016. 
 
The Company expects to report a slightly lower than expected loss before tax of 
approximately GBP3.7m for the year ended 31 December 2014. The loss reflects 
slightly lower than expected expenditure on R&D and slightly lower expenditure 
than expected on general and administrative costs. Costs associated with 
expansion of the senior management team and board only incurred towards the end 
of the year. 
 
Update on RPL554 Development Programme 
 
Verona Pharma is fully focused on developing RPL554 and in January this year 
announced that the first subjects had successfully been dosed in the initial 
clinical trial with its new proprietary and commercially scalable nebulized 
formulation of RPL554. The initial clinical trials are designed to prepare 
RPL554 for the treatment of acute exacerbations of chronic obstructive 
pulmonary disease (COPD). 
 
The Board remains excited by the prospects for RPL554 as it advances further 
into development in 2015. Following a thorough review of the planned 
development and associated expenditure for RPL554, the Board has concluded that 
it is now timely to accelerate the work on the drug to progress to the start of 
phase IIb clinical trials in 2016. Therefore, gross R&D expense to be incurred 
in 2015 will be substantially greater than previously expected. The higher R&D 
spending in 2015 essentially results from moving work forward from 2016 into 
the current year. 
 
The overall expenditures for 2015 are currently expected to be approximately a 
third higher than previously anticipated, before taking into account the 
prospective benefit of R&D tax credits. The Company will continue to apply for 
these and reasonably expects such recovery to rise proportionately with the 
increased R&D expenditure and be realised in the subsequent accounting period. 
 
In Q4 2014, the Board was strengthened by the addition of a highly experienced 
new Chairman and a full-time Chief Financial Officer with significant 
transaction experience. In addition, senior management was augmented at the 
beginning of this year with the appointment of an experienced Chief Medical 
Officer, a pulmonologist with deep respiratory expertise. 
 
Dr Jan-Anders Karlsson, Chief Executive Officerof Verona Pharma, said: 
 
"We plan to start a number of additional studies with the new proprietary 
formulation of RPL554 this year. The aim of these studies is to confirm its 
benign safety profile while further demonstrating the pronounced bronchodilator 
activity in healthy subjects, asthmatics and COPD patients of this unique 
first-in-class drug. Results from these trials will be reported as they occur 
on an ongoing basis during the year. We will be able to provide the first 
update from the on-going study in the Medicines Evaluation Unit, Manchester, at 
the beginning of the second quarter, which is earlier than expected." 
 
                                    -Ends- 
 
For further information please contact: 
 
Verona Pharma plc                       Tel: +44 (0) 20 3283 4200 
 
Jan-Anders Karlsson, Chief Executive 
Officer 
 
N+1 Singer                              Tel: +44 (0)20 7496 3000 
 
Aubrey Powell / Jen Boorer 
 
FTI Consulting                          Tel: +44 (0)20 3727 1000 
 
Julia Phillips / Simon Conway 
 
Notes to Editors 
 
About Verona Pharma plc 
 
Verona Pharma plc is a UK-based clinical stage biopharmaceutical company 
focused on the development of innovative prescription medicines to treat 
respiratory diseases with significant unmet medical needs, such as chronic 
obstructive pulmonary disease (COPD), asthma and cystic fibrosis. 
 
Verona Pharma's lead drug, RPL554, is a first-in-class drug currently in Phase 
II trials as a nebulised treatment for acute exacerbations of COPD in the 
hospital setting. The drug is a dual phosphodiesterase (PDE) 3/4 inhibitor and 
therefore has both bronchodilator and anti-inflammatory effects, which are 
essential to the improvement of patients with COPD and asthma. 
 
Verona Pharma is also building a broader portfolio of RPL554-containing 
products to maximise its benefit to patients and its value. This includes the 
very significant markets for COPD and asthma maintenance therapy. The Company 
is also exploring the potential of the drug in different diseases, such as 
cystic fibrosis, where it is in pre-clinical testing and has recently received 
a Venture and Innovation Award from the Cystic Fibrosis Trust. 
 
About Chronic Obstructive Pulmonary Disease (COPD) 
 
Sixty-five million people worldwide suffer from moderate to severe COPD and the 
World Health Organisation (WHO) expects COPD to be the 3rd leading cause of 
death globally by 2020. It is the only major chronic disease with increasing 
mortality. Currently available drugs are aimed at long-term maintenance 
therapy, with the market dominated by large pharma. Despite the wide 
availability of these therapies, COPD patients suffer acute periods of 
worsening symptoms (exacerbations), which cause, in the US alone, some 1.5 
million A&E visits, 726,000 hospitalisations and 120,000 deaths per annum. 
 
IMS Consulting Group considers bronchodilating therapy to be the standard of 
care, and agents can be administered via handheld devices such as metered dose 
inhaler (MDI), dry powder inhaler (DPI) and by nebulisers. The nebulised 
bronchodilator market was worth about $1 billion in 2014 in the US. RPL554 is 
being developed by Verona Pharma as an add-on therapy to the "Standard of Care" 
with the objectives of providing rapid and pronounced improvement in lung 
function, reduced symptoms and both shortened duration of hospital stays and 
reduced re-admission rates 30 days after discharge from hospital. Studies to 
date on RPL554 have demonstrated that it has a strongly differentiated 3-way 
mode of action, being: (1) bronchodilation (the relaxation of smooth muscle in 
the airway); (2) anti-inflammatory effects on cells and (3) ion channel 
activation in epithelial cells, with increased mucociliary clearance of the 
airway. 
 
 
 
END 
 

Verona Pharma (LSE:VRP)
Historical Stock Chart
From Jun 2024 to Jul 2024

Verona Pharma (LSE:VRP)
Historical Stock Chart
From Jul 2023 to Jul 2024