RNS Number:7869L
Profile Therapeutics PLC
2 June 2003



Letters to: Profile Therapeutics PLC

Dated: 2nd June 2003

In accordance with the provisions of sections 198-202 Companies Act 1985, as
amended by sections 134 (1) to (3) of the Companies Act 1989.  We give notice
that as a result of a sale of 2,174,528 ordinary shares on 16th May 2003, we
now have an interest in 0 shares in your company, representing 0.00 per cent
of the issued share capital.

From:   Investment Operations
        Insight Investment
        Equitable Life Assurance Society


Following on from our telephone conversation on 31st May 2003 I can confirm
that HBOS plc and its subsidiaries have a non-material interest in the shares
of your company as follow:-

Sedol     No of Shares     Security class     Fund          Registered Holder

0138622   2,766,000        Ordinary 2p        EQSCO         HSBC Global Custody
                                                            Nominees (UK) Ltd
                                                            a/c 39765406

HBOS plc's non-material interest is 2,766,000 units which is 5.63% of the
shares in issue.

From  Investment Operations
      Insight Investment

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            The company news service from the London Stock Exchange


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