Holding(s) in Company

RNS Number : 1193L
Osmetech PLC
05 January 2009

5 January 2009
Disclosure of Significant Shareholdings

Osmetech PLC ("Osmetech" or "the Company") (AIM:OMH) announces that it was notified between 23 December 2008 and 2 January 2009 of the
following changes in shareholdings of ordinary 0.1p shares pursuant to the placing announced on 22 December 2008:

1. Efficacy Capital Ltd has increased its shareholding in Osmetech from 125,822,641 to 291,457,742 shares, representing 32.69% of the
Company*s issued share capital. The shareholding is held in two entities:
� Efficacy Biotech Master Fund which holds 288,487,742 shares representing 32.36% of Company*s issued share capital.
� FMG Special Opportunity Fund which holds 2,970,000 shares representing 0.33% of Company*s issued share capital.

2. Gartmore Investment Limited has increased its shareholding in Osmetech from 74,047,430 to 166,446,397 shares, representing 18.67% of
the Company*s issued share capital.

3. Polar Capital Healthcare Opportunities Fund has increased its shareholding in Osmetech from 24,800,660 to 66,951,936 shares,
representing 7.51% of the Company*s issued share capital.

The total number of issued ordinary 0.1p shares is 891,607,157. Osmetech does not hold any ordinary shares in Treasury. Therefore, the
total number of voting rights in Osmetech is 891,607,157.

For further information:

Osmetech plc: +44 (0) 20 7849 6027
James White, Chief Executive
David Sandilands, Finance Director

Madano Partnership: +44 (0) 207 593 4000
Mark Way
Graham Moonie

Canaccord Adams Limited: +44 (0) 20 7050 6500
Robert Finlay
Henry Fitzgerald-O'Connor

This information is provided by RNS
The company news service from the London Stock Exchange

END

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