Threshold Pharmaceuticals Inc - Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Expires: February 28, 2011 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

ALTA BIOPHARMA PARTNERS III LP

2. Date of Event Requiring Statement (MM/DD/YYYY) 8/29/2008

3. Issuer Name and Ticker or Trading Symbol

THRESHOLD PHARMACEUTICALS INC [THLD]

(Last) (First) (Middle)

ONE EMBARCADERO CENTER, SUITE 3700

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director ___ X ___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

SAN FRANCISCO, CA 94111

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	1200154	I	By limited partnership ⁽¹⁾ ⁽²⁾
Common Stock	80601	I	By limited partnership ⁽²⁾ ⁽³⁾
Common Stock	29576	I	By limited liability company ⁽²⁾ ⁽⁴⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Warrant	⁽⁵⁾	8/29/2013	Common Stock	404080	$2.34	I	By limited partnership ⁽¹⁾ ⁽²⁾
Warrant	⁽⁵⁾	8/29/2013	Common Stock	27137	$2.34	I	By limited partnership ⁽²⁾ ⁽³⁾
Warrant	⁽⁵⁾	8/29/2013	Common Stock	9958	$2.34	I	By limited liability company ⁽²⁾ ⁽⁴⁾

Explanation of Responses:
( 1)	These securities are held by Alta BioPharma Partners III, L.P. ("ABPIII").
( 2)	Alta BioPharma Management III, LLC ("ABMIII") is the general partner of ABPIII and the managing limited partner of Alta BioPharma Partners III GmbH & Co. Beteiligungs KG("ABPIIIKG"). Jean Deleage, Farah Champsi, Edward Penhoet, Edward Hurwitz, and Alix Marduel are directors of ABMIII and managers of Alta Embarcadero BioPharma Partners III, LLC ("AEBPIII" and, along with ABMIII and ABPIIIKG, the "Funds")and exercise shared voting and investment power with respect to the securities held by the funds. Each of the reporting persons disclaims beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.
( 3)	These securities are held by ABPIIIKG.
( 4)	These securities are held by AEBPIII.
( 5)	These warrants are immediately exercisable.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
ALTA BIOPHARMA PARTNERS III LP ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
ALTA BIOPHARMA PARTNERS III GMBH & CO BETEILIGUNGS KG ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
ALTA EMBARCADERO BIOPHARMA PARTNERS III LLC ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
DELEAGE JEAN ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
CHAMPSI FARAH ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
PENHOET EDWARD ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
HURWITZ EDWARD ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
ALTA BIOPHARMA MANAGEMENT III LLC ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X
MARDUEL ALIX ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO, CA 94111		X

Signatures
Alta BioPharma Partners III, L.P. By: Alta BioPharma Management III, LLC, its General Partner /s/ Jean Deleage, Director		9/5/2008
^** Signature of Reporting Person		Date
By: Alta BioPharma Management III, LLC, it's Managing Limited Partner		9/5/2008
^** Signature of Reporting Person		Date
/s/ Jean Deleage, Manager		9/5/2008
^** Signature of Reporting Person		Date
/s/ Jean Deleage		9/5/2008
^** Signature of Reporting Person		Date
/s/ Farah Champsi		9/5/2008
^** Signature of Reporting Person		Date
/s/ Edward Penhoet		9/5/2008
^** Signature of Reporting Person		Date
/s/ Edward Hurwitz		9/5/2008
^** Signature of Reporting Person		Date
/s/ Jean Deleage, Director		9/5/2008
^** Signature of Reporting Person		Date
/s/ Alix Marduel		9/5/2008
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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