TIDMSHP 
 
 
 
   Holding(s) in Company 
 
   January 7, 2019 -- Shire plc (LSE: SHP, NASDAQ: SHPG) 
 
 
 
 
1a. Identity of the issuer or the underlying issuer 
 of existing shares to which voting rights are attached(ii)                                                                                       Shire Plc 
 :                                                                                                                                                 JE00B2QKY057 
------------------------------------------------------------------------------------------------------------------------------------------------  ----------------------------------------------------------------------------------------------------------------------------------- 
1b. Please indicate if the issuer is a non-UK issuer 
 (please mark with an "X" if appropriate) 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
Non-UK issuer                                                                                                                                                                                                                                                        X 
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------------------------------ 
2. Reason for the notification (please mark the appropriate 
 box or boxes with an "X") 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
An acquisition or disposal of voting rights 
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------------------------------ 
An acquisition or disposal of financial instruments                                                                                                                                                                                                                  X 
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------------------------------ 
An event changing the breakdown of voting rights 
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------------------------------ 
Other (please specify)(iii) : 
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------  ------------------------------ 
3. Details of person subject to the notification obligation(iv) 
                                                                                                                                                  UBS Investment Bank 
Name                                                                                                                                               UBS Group AG 
                                                                                                                                                  Zürich 
City and country of registered office (if applicable)                                                                                              Switzerland 
4. Full name of shareholder(s) (if different from 
 3.)(v) 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
Name                                                                                                                                              UBS AG London Branch 
------------------------------------------------------------------------------------------------------------------------------------------------  ----------------------------------------------------------------------------------------------------------------------------------- 
City and country of registered office (if applicable)                                                                                             London, United Kingdom 
------------------------------------------------------------------------------------------------------------------------------------------------  ----------------------------------------------------------------------------------------------------------------------------------- 
5. Date on which the threshold was crossed or reached(vi) 
 :                                                                                                                                                3 January 2019 
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6. Date on which issuer notified (DD/MM/YYYY):                                                                                                    7 January 2019 
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7. Total positions of person(s) subject to the notification 
 obligation 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
                                                                          % of voting rights attached to shares (total of 8.                       % of voting rights through financial instruments                                                    Total number of voting rights 
                                                                                                   A)                                                          (total of 8.B 1 + 8.B 2)                       Total of both in % (8.A + 8.B)           of issuer(vii) 
-----------------------------------------------------  -----------------------------------------------------------------------------------------  --------------------------------------------------  -----------------------------------------------  ------------------------------ 
Resulting situation on the date on which threshold 
 was crossed or reached                                                                      6.80%                                                              0.78%                                                         7.58%                     918,120,398 
-----------------------------------------------------  ------------------------------------------   --------------------------------------------  ------------------   -----------------------------  ----------------------------   ----------------  ------------  ---------------- 
Position of previous notification (if 
 applicable)                                                                                 6.86%                                                              2.23%                                                         9.10% 
-----------------------------------------------------  ------------------------------------------   --------------------------------------------  ------------------   -----------------------------  ----------------------------   ----------------  ------------------------------ 
 
 8. Notified details of the resulting situation on 
 the date on which the threshold was crossed or reached(viii) 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
A: Voting rights attached to shares 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
                                                      Number of voting rights(ix)                                                                                                                                                                                  % of voting rights 
--------------------------------------------------- 
Class/type of 
 shares                                                                 Direct                                       Indirect                                                          Direct                                                           Indirect 
 ISIN code (if possible)                               (Art 9 of Directive 2004/109/EC) (DTR5.1)    (Art 10 of Directive 2004/109/EC) (DTR5.2.1)                      (Art 9 of Directive 2004/109/EC) (DTR5.1)                        (Art 10 of Directive 2004/109/EC) (DTR5.2.1) 
----------------------------------------------------  -------------------------------------------  ---------------------------------------------  --------------------------------------------------------------------------------  ------------------------------------------------- 
                    JE00B2QKY057                                                                                    62'432'281                                                                                                                                 6.80% 
----------------------------------------------------  -------------------------------------------  ---------------------------------------------  --------------------------------------------------------------------------------  ------------------------------- --------------- 
 
 
SUBTOTAL 8. A                                                                                 62'432'281                                                                                                                                                       6.80% 
----------------------------------------------------  ------------------------------------------------------------------------------------------  ----------------------------------------------------------------------------------------------------------------- --------------- 
 
B 1: Financial Instruments according to Art. 13(1)(a) 
 of Directive 2004/109/EC (DTR5.3.1.1 (a)) 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
                                                                                                                                                                               Number of voting rights that may be acquired if the 
                                                      Expiration                                                                       Exercise/                                                                     instrument is 
Type of financial instrument                           date(x)                                                             Conversion Period(xi)                                                              exercised/converted.                                 % of voting rights 
----------------------------------------------------  -------------------------------------------  ---------------------------------------------  --------------------------------------------------------------------------------  ------------------------------------------------- 
Right to recall lent ADRs (US82481R1068)                                                                              Anytime                                                         396'000                                                                  0.04% 
----------------------------------------------------  -------------------------------------------  ---------------------------------------------  --------------------------------------------------------------------------------  ------------------------------- --------------- 
US82481R1068                                                                                                                                                                         5'174'370                                                                 0.56% 
----------------------------------------------------  -------------------------------------------  ---------------------------------------------  --------------------------------------------------------------------------------  ------------------------------- --------------- 
Physically settled Long Call Options                  18/01/2019 to 18/04/2019                                                                                                        933'000                                                                  0.10% 
----------------------------------------------------  -------------------------------------------  ---------------------------------------------  --------------------------------------------------------------------------------  ------------------------------- --------------- 
                                                                                                                  SUBTOTAL 8. B 1                                                    6'503'370                                                                 0.71% 
                                                                                                   ---------------------------------------------  --------------------------------------------------------------------------------  ------------------------------- --------------- 
 
B 2: Financial Instruments with similar economic effect 
 according to Art. 13(1)(b) of Directive 2004/109/EC 
 (DTR5.3.1.1 (b)) 
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 
                                                     Expiration                                                                        Exercise/                                    Physical or cash 
Type of financial instrument                         date(x)                                                              Conversion Period (xi)                                     settlement(xii)       Number of voting rights                                 % of voting rights 
---------------------------------------------------  --------------------------------------------  ---------------------------------------------  --------------------------------------------------  ----------------------------  ------------------------------------------------- 
Short Put Options                                                     18/01/2019                                                                                                            Physical                       658'800                             0.07% 
---------------------------------------------------  --------------------------------------------  ---------------------------------------------  --------------------------------------------------  ----------------------------  ------------------------------- --------------- 
 
 
                                                                                                                                                                                      SUBTOTAL 8.B.2                       658'800                             0.07% 
                                                                                                                                                  --------------------------------------------------  ----------------------------  ------------------------------- --------------- 
 
 
 
 
 
 
 
9. Information in relation to the person subject to 
 the notification obligation (please mark the 
 applicable box with an "X") 
Person subject to the notification obligation is not 
 controlled by any natural person or legal entity and 
 does not control any other undertaking(s) holding 
 directly or indirectly an interest in the (underlying) 
 issuer(xiii) 
Full chain of controlled undertakings through which 
 the voting rights and/or the 
 financial instruments are effectively held starting 
 with the ultimate controlling natural person or legal 
 entity(xiv) (please add additional rows as necessary)                                                                                                  X 
------------------------------------------------------------------------------------------------------------------------  ------------------------------------------------------------- 
               % of voting rights if it equals or is higher than    % of voting rights through financial instruments if    Total of both if it equals or is higher than the notifiable 
  Name(xv)                  the notifiable threshold                it equals or is higher than the notifiable threshold                            threshold 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS Group AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS AG 
 London 
 Branch                     6.80%                                                                                                           7.58% 
------------  ------------------   ------------------------------  -----------------------------------------------------  ---------------------- ------------------------------------ 
 
UBS Group AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS Limited 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
 
UBS Group AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS 
 Switzerland 
 AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
 
UBS Group AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS AG 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS Americas 
 Holding 
 LLC 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS Americas 
 Inc. 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
UBS 
 Securities 
 LLC 
------------  ---------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
 
 
 
 
 
 
 
10. In case of proxy voting, please identify: 
----------------------------------------------------- 
Name of the proxy holder 
--------------------------------------------------- 
The number and % of voting rights held 
--------------------------------------------------- 
The date until which the voting rights will be held 
--------------------------------------------------- 
 
11. Additional information(xvi) 
----------------------------------------------------- 
 
 
 
 
 
 
 
Place of completion  Opfikon, Switzerland 
-------------------  -------------------- 
Date of completion   07.01.2019 
-------------------  -------------------- 
 
 
   For further information please contact: 
 
 
 
 
Investor Relations 
Christoph Brackmann   christoph.brackmann@shire.com   +41 41 288 41 29 
Sun Kim               sun.kim@shire.com                +1 617 588 8175 
Scott Burrows         scott.burrows@shire.com          +41 41 288 4195 
 
Media 
Katie Joyce           kjoyce@shire.com                 +1 781 482 2779 
 
 
 
   NOTES TO EDITORS 
 
   About Shire 
 
   Shire is the global biotechnology leader serving patients with rare 
diseases and specialized conditions. We seek to push boundaries through 
discovering and delivering new possibilities for patient communities who 
often have few or no other champions. Relentlessly on the edge of what's 
next, we are serial innovators with a diverse pipeline offering fresh 
thinking and new hope. Serving patients and partnering with healthcare 
communities in over 100 countries, we strive to be part of the entire 
patient journey to enable earlier diagnosis, raise standards of care, 
accelerate access to treatment, and support patients. Our diverse 
portfolio of therapeutic areas includes Immunology, Hematology, Genetic 
Diseases, Neuroscience, Internal Medicine, and Ophthalmics. 
 
 
 
   Championing patients is our call to action - it brings the opportunity - 
and responsibility - to change people's lives. 
 
   https://www.globenewswire.com/Tracker?data=vAa6XY7wcDQA3UjgcCXVq7VqKN9GX3z1jLwa-g7czTGD_rE4Jx0Us_R6xXmX4WdOlAhJpM-Lj-qZKjMhezgEQA== 
www.shire.com 
 
 
 
 

(END) Dow Jones Newswires

January 07, 2019 12:15 ET (17:15 GMT)

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