Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* CMLS Holdings III LLC	2. Issuer Name and Ticker or Trading Symbol CM Life Sciences III Inc. [ CMLT ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) C/O CORVEX MANAGEMENT LP, 667 MADISON AVENUE	3. Date of Earliest Transaction (MM/DD/YYYY) 8/1/2021
(Street) NEW YORK, NY 10065 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Class B common stock	⁽¹⁾	8/1/2021		S			200000	⁽¹⁾	⁽¹⁾	Class A common stock	200000	$0.002 ⁽¹⁾⁽²⁾	13500000	I ⁽³⁾	See footnote ⁽³⁾

Explanation of Responses:
(1)	The shares of Class B common stock will automatically convert into shares of Class A common stock at the time of the issuer's initial business combination or earlier at the option of the holder as described under the heading "Description of Securities--Founder Shares" in the Issuer's registration statement on Form S-1 (File No. 333-253475) (the "Registration Statement"), on a one-for-one basis, subject to adjustment for stock splits, stock capitalizations, reorganizations, recapitalizations and the like, and certain anti-dilution rights and have no expiration date.
(2)	Sale of Class B common stock to an independent director of the issuer.
(3)	CMLS Holdings III LLC is the record holder of the shares reported herein. The Board of Managers of CMLS Holdings III LLC is comprised of Mr. Casdin and Mr. Meister who share voting and investment discretion with respect to the common stock held of record by CMLS Holdings III LLC. C-LSH III LLC and M-LSH III LLC are the members of CMLS Holdings III LLC, and Mr. Casdin and Mr. Meister are the managing members of C-LSH III LLC and M-LSH III LLC, respectively. Each of C-LSH III LLC, M-LSH III LLC and Messrs. Casdin and Meister disclaims beneficial ownership of these shares except to the extent of its or his respective pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
CMLS Holdings III LLC C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE NEW YORK, NY 10065	X	X
C-LSH III LLC C/O CASDIN CAPITAL, LLC 1350 AVE OF THE AMERICAS, SUITE 2600 NEW YORK, NY 10019	X	X
M-LSH III LLC C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE NEW YORK, NY 10065	X	X
Casdin Eli C/O CASDIN CAPITAL, LLC 1350 AVE OF THE AMERICAS, SUITE 2600 NEW YORK, NY 10019	X	X	Officer (CEO)
Meister Keith A. C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE NEW YORK, NY 10065	X	X

Signatures
/s/ Brian Emes as Attorney-in-Fact for CMLS Holdings III LLC		8/3/2021
^**Signature of Reporting Person		Date
/s/ Brian Emes as Attorney-in-Fact for C-LSH III LLC		8/3/2021
^**Signature of Reporting Person		Date
/s/ Brian Emes as Attorney-in-Fact for M-LSH III LLC		8/3/2021
^**Signature of Reporting Person		Date
/s/ Brian Emes as Attorney-in-Fact for Eli Casdin		8/3/2021
^**Signature of Reporting Person		Date
/s/ Brian Emes as Attorney-in-Fact for Keith A. Meister		8/3/2021
^**Signature of Reporting Person		Date