Washington, D.C. 20549
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO §
24.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13D-2(a)
(Amendment No. 2)*
If the filing person
has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing
this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box ☐.
* The remainder of this cover page shall be filled out for a
reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page
shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page
2 of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
Deerfield Mgmt, L.P.
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
AF
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
613,611 (1)
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
613,611 (1)
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
613,611 (1)
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
2.21%
|
|
14
|
TYPE OF REPORTING PERSON
PN
|
|
(1) Comprised of 413,611 shares held by Deerfield Special Situations
Fund, L.P., 88,000 shares held by Deerfield Partners, L.P. and 112,000 shares held by Deerfield International Master Fund, L.P.
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page 3
of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
Deerfield
Special
Situations Fund, L.P.
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
WC
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
413,611
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
413,611
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
413,611
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.49%
|
|
14
|
TYPE OF REPORTING PERSON
PN
|
|
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page 4
of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
Deerfield Partners, L.P.
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
WC
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
88,000
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
88,000
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
88,000
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
0.32%
|
|
14
|
TYPE OF REPORTING PERSON
PN
|
|
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page 5
of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
Deerfield International Master Fund, L.P.
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
WC
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
British Virgin Islands
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
112,000
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
112,000
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
112,000
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
0.40%
|
|
14
|
TYPE OF REPORTING PERSON
PN
|
|
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page 6
of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
Deerfield Private Design Fund III, L.P.
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
WC
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
1,623,089
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
1,623,089
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,623,089
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
5.84%
|
|
14
|
TYPE OF REPORTING PERSON
PN
|
|
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page 7
of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
Deerfield Management Company, L.P.
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
AF
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
2,252,128 (2)
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
2,252,128 (2)
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,252,128 (2)
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
8.10%
|
|
14
|
TYPE OF REPORTING PERSON
PN
|
|
(2) Comprised of 413,611 shares held by Deerfield Special Situations
Fund, L.P., 88,000 shares held by Deerfield Partners, L.P., 1,623,089 shares held by Deerfield Private Design Fund III, L.P.,
112,000 shares held by Deerfield International Master Fund, L.P. and 15,428 shares of Common Stock underlying options held by
Jonathan Leff, a partner in Deerfield Management Company, L.P. and a former director of the Issuer.
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page 8
of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
Deerfield Mgmt III, L.P.
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
AF
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
1,623,089 (3)
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
1,623,089 (3)
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,623,089 (3)
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
5.84%
|
|
14
|
TYPE OF REPORTING PERSON
PN
|
|
(3) Comprised of 1,623,089 shares held by Deerfield Private
Design Fund III, L.P.
SCHEDULE 13D
CUSIP
No.
05366U100
|
Page 9
of 15 Pages
|
1
|
NAME OF REPORTING PERSONS
James E. Flynn
|
|
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
|
(a) ☐
(b) ☒
|
3
|
SEC USE ONLY
|
|
4
|
SOURCE OF FUNDS
AF
|
|
5
|
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
TO ITEMS 2(d) or 2(e)
|
☐
|
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
United States of America
|
|
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
2,252,128 (4)
|
|
9
|
SOLE DISPOSITIVE POWER
0
|
|
10
|
SHARED DISPOSITIVE POWER
2,252,128 (4)
|
|
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,252,128 (4)
|
|
12
|
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
SHARES*
|
☐
|
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
8.10%
|
|
14
|
TYPE OF REPORTING PERSON
IN
|
|
(4) Comprised of 413,611 shares held by Deerfield Special Situations
Fund, L.P., 88,000 shares held by Deerfield Partners, L.P., 1,623,089 shares held by Deerfield Private Design Fund III, L.P.,
112,000 shares held by Deerfield International Master Fund, L.P. and 15,428 shares of Common Stock underlying options held by
Jonathan Leff, a partner in Deerfield Management Company, L.P. and a former director of the Issuer.
CUSIP
No.
05366U100
|
13D/A
|
Page 10
of 15 Pages
|
This Amendment No. 2 (this “
Amendment
”)
to Schedule 13D amends the Schedule 13D (as previously amended, the “
Schedule 13D
”) filed by (i) Deerfield Mgmt,
L.P. (“
Deerfield Mgmt
”), (ii) Deerfield Special Situations Fund, L.P. (“
Deerfield Special Situations
Fund
”), (iii) Deerfield Management Company, L.P. (“
Deerfield Management
”), (iv) Deerfield Private
Design Fund III, L.P. (“
Deerfield Private Design Fund III”
), (v) Deerfield Partners, L.P. (“
Deerfield
Partners
”), (vi) Deerfield International Master Fund, L.P. (“
Deerfield International Master Fund
”),
(vii) Deerfield Mgmt III, L.P. (“
Deerfield Mgmt III
”) and (viii) James E. Flynn, a natural person (“
Flynn
”
and collectively with Deerfield Mgmt, Deerfield Special Situations Fund, Deerfield Management, Deerfield Private Design Fund III,
Deerfield Partners, Deerfield International Master Fund and Deerfield Mgmt III, the “
Reporting Persons
”), with
respect to the securities of AveXis, Inc. (the “
Company
”), on February 19, 2016, as amended by Amendment No.
1 to the Schedule 13D filed on February 2, 2017. Deerfield Special Situations Fund, Deerfield Private Design Fund III, Deerfield
Partners and Deerfield International Master Fund are collectively referred to herein as the “
Funds
.”
Capitalized terms used herein but not otherwise defined herein
shall have the meanings ascribed to them in the Schedule 13D.
Item 4. Purpose of the Transaction
Item 4 of the Schedule 13D is hereby amended by adding the
following:
As previously disclosed by the Company, Jonathan Leff, a partner
of Deerfield Management, did not stand for re-election to the Company’s board of directors at the Company’s 2017 annual
meeting of stockholders (the “Annual Meeting”). Accordingly, Mr. Leff’s term as a director expired on May 30,
2017, the date of the Annual Meeting.
Item 5. Interest in Securities of the Issuer.
Items 5(a), (b) and (c) of the Schedule 13D are hereby amended
and restated in their entirety as follows:
(a)
(1)
Deerfield
Mgmt
Number
of shares:
|
613,611 (comprised of shares held by Deerfield Special Situations Fund, Deerfield Partners and Deerfield International
Master Fund)
|
Percentage
of shares: 2.21%*
(2)
Deerfield
Management
Number of shares:
|
2,252,128
(comprised of shares held by Deerfield Special Situations Fund, Deerfield Private Design Fund III, Deerfield Partners and Deerfield
International Master Fund, and 15,428 shares underlying options held by Jonathan Leff, to the extent such options are vested)
|
Percentage
of shares: 8.10%*
CUSIP
No.
05366U100
|
13D/A
|
Page 11
of 15 Pages
|
(3)
Deerfield
Special Situations Fund
Number of shares: 413,611
Percentage
of shares 1.49%*
(4)
Deerfield
Private Design Fund III
Number of shares: 1,623,089
Percentage of shares: 5.84%*
(5)
Deerfield
Partners
Number of Shares: 88,000
Percentage of Shares: 0.32%*
(6)
Deerfield
International Master Fund
Number of Shares: 112,000
Percentage of Shares: 0.40%*
(7)
Deerfield
Mgmt III
Number of shares: 1,623,089
(comprised of shares held by Deerfield Private Design Fund III)
Percentage of shares: 5.84%*
(8)
Flynn
Number of shares:
|
2,252,128
(comprised of shares held by Deerfield Special Situations Fund, Deerfield Partners, Deerfield International Master Fund and Deerfield
Private Design Fund III, and 15,428 shares underlying options held by Jonathan Leff, to the extent such options are vested)
|
Percentage of shares: 8.10%*
*Percentage beneficial ownership reported herein reflects 27,794,558
shares of Common Stock outstanding as of May 11, 2017, as reported in the Company’s Quarterly Report on Form 10-Q for the
quarterly period ended March 31, 2017.
(b)
(1)
Deerfield
Mgmt
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
613,611
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
613,611
CUSIP
No.
05366U100
|
13D/A
|
Page 12
of 15 Pages
|
(2)
Deerfield
Management
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
2,252,128
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
2,252,128
(3)
Deerfield
Special Situations Fund
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
413,611
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
413,611
(4)
Deerfield
Private Design Fund III
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
1,623,089
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
1,623,089
(5)
Deerfield
Partners
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
88,000
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
88,000
(6)
Deerfield
International Master Fund
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
112,000
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
112,000
(7)
Deerfield
Mgmt III
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
1,623,089
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
1,623,089
CUSIP
No.
05366U100
|
13D/A
|
Page 13
of 15 Pages
|
(8)
Flynn
Sole power to vote or direct the vote: 0
Shared power to vote or direct the vote:
2,252,128
Sole power to dispose or to direct the disposition:
0
Shared power to dispose or direct the disposition:
2,252,128
Flynn is the sole member of the general
partner of each of Deerfield Mgmt, Deerfield Mgmt III and Deerfield Management. Deerfield Mgmt is the general partner, and Deerfield
Management is the investment advisor, of Deerfield Special Situations Fund, Deerfield Partners and Deerfield International Master
Fund. Deerfield Mgmt III is the general partner, and Deerfield Management is the investment advisor, of Deerfield Private Design
Fund III. Pursuant to an arrangement between Deerfield Management and Leff, for so long as Leff is employed by Deerfield Management,
any compensation that Leff receives from the Issuer is for the economic benefit of Deerfield Management and must be transferred
to Deerfield Management, for no consideration, subject to applicable restrictions on transfer. See Item 6 of the Schedule 13D for
additional information regarding such arrangement.
(c) No Reporting Person has effected any
transactions in the Company’s securities since the initial filing of the Schedule 13D. The changes in the percentage of Common
Stock beneficially owned by each Reporting Person reflected in this Amendment have resulted solely from an increase in the number
of shares of Common Stock outstanding.
CUSIP
No.
05366U100
|
13D/A
|
Page 14
of 15 Pages
|
SIGNATURE
After reasonable inquiry
and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true,
complete and correct.
Dated: May 31, 2017
|
DEERFIELD MGMT, L.P.
By: J.E. Flynn Capital, LLC, General Partner
By:
/s/ Jonathan Isler
Name: Jonathan Isler
Title: Attorney-in-Fact
DEERFIELD MGMT III, L.P.
By: J.E. Flynn Capital III, LLC, General Partner
By:
/s/ Jonathan Isler
Name: Jonathan Isler
Title: Attorney-in-Fact
DEERFIELD SPECIAL SITUATIONS FUND, L.P.
By: Deerfield Mgmt, L.P., General Partner
By: J.E. Flynn Capital, LLC, General Partner
By:
/s/ Jonathan Isler
Name: Jonathan Isler
Title: Attorney-in-Fact
DEERFIELD PRIVATE DESIGN FUND III, L.P.
By: Deerfield Mgmt III, L.P., General Partner
By: J.E. Flynn Capital III, LLC, General Partner
By:
/s/ Jonathan Isler
Name: Jonathan Isler
Title: Attorney-in-Fact
|
CUSIP
No.
05366U100
|
13D/A
|
Page 15
of 15 Pages
|
|
DEERFIELD INTERNATIONAL MASTER FUND,
L.P.
By: Deerfield Mgmt, L.P., General Partner
By: J.E. Flynn Capital, LLC, General Partner
By:
/s/ Jonathan Isler
Name: Jonathan Isler
Title: Attorney-in-Fact
DEERFIELD PARTNERS, L.P.
By: Deerfield Mgmt, L.P., General Partner
By: J.E. Flynn Capital, LLC, General Partner
By:
/s/ Jonathan Isler
Name: Jonathan Isler
Title: Attorney-in-Fact
DEERFIELD MANAGEMENT COMPANY, L.P.
By: Flynn Management LLC, General Partner
By:
/s/ Jonathan Isler
Name: Jonathan Isler
Title: Attorney-in-Fact
JAMES E. FLYNN
/s/ Jonathan Isler
Jonathan Isler, Attorney-in-Fact
|