Stratagene Introduces a New Product for Human Splice Variant Discovery
April 05 2006 - 6:30AM
Business Wire
Stratagene Corporation (NASDAQ:STGN), a developer, manufacturer and
marketer of specialized life science research and diagnostic
products, today announced the commercial availability of the Human
SpliceMiner(TM) cDNA Library Panel. This new product greatly
simplifies the process of discovering rare and unique alternative
splice forms that would have otherwise been difficult or impossible
to detect by current methods. "Defects in mRNA splicing are an
important cause of disease. Alternative splicing has also been
found to be associated with cancer and may also play a role in the
pharmacological properties of drugs. Many of our SpliceMiner panel
cancer cell lines are in use at the National Cancer Institute of
the US National Institutes of Health to screen for anticancer
drugs," said David Weber, Senior Vice President of Marketing for
Stratagene. "We believe that the area of alternative splicing is a
growing market and that the new SpliceMiner panel provides an
effective discovery method that can be practiced in any molecular
biology laboratory." The Human SpliceMiner cDNA library panel
consists of ~4.6 million primary cDNA clones derived from 15
high-quality cDNA plasmid libraries representing 28 cancer cell
lines and 32 normal human tissues, including 14 sub-regions of the
brain. The SpliceMiner panel design facilitates capture of rare
mRNAs and is enriched for complete cDNA transcripts, while
maintaining mRNA representation found in the original human source
material. Unlike a traditional cDNA library where the entire
content is pooled into one highly complex sample, SpliceMiner cDNA
clones are arrayed into 384 lower complexity pools (4 x 96 well
format). The pools are strategically segregated to enhance the
probability of amplifying one specific splice variant per well. The
segregated pool in each well contains ~12,000 clones. By amplifying
multiple lower-complexity pools, the statistical probability of
finding a single splice variant of a particular mRNA is vastly
improved, especially for low-to-medium abundance transcripts. The
new Human SpliceMiner panel is a perfect downstream solution for
those wanting to find new splice variants of their gene and to
further analyze data generated with new exon and tiling arrays
recently introduced into the market. For more information, visit
http://www.stratagene.com/products/displayProduct.aspx?pid=781
About Stratagene Corporation Stratagene is a developer, marketer
and manufacturer of specialized life science research and
diagnostic products. The Company's life science research unit
supports advances in science by inventing, manufacturing and
distributing products that simplify, accelerate and improve
research. These products are used throughout the academic,
industrial and government research sectors in fields spanning
molecular biology, genomics, proteomics, drug discovery and
toxicology. The Company's diagnostic unit develops and manufactures
products for urinalysis, and high quality automated instrument and
reagent systems that use blood samples to test for more than 1,000
different allergies and autoimmune disorders. In addition, by
combining its expertise in diagnostics and molecular biology, as
well as its experience with FDA regulatory procedures, the Company
is pursuing opportunities to expand its product portfolio to
include molecular diagnostic kits and instrumentation. More
information is available at www.stratagene.com.
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