NaPro Announces the Sale of Two Million Common Shares BOULDER, Colo., March 26 /PRNewswire-FirstCall/ -- NaPro BioTherapeutics, Inc. today announced that it has entered into a transaction with two institutional investors for the purchase of an aggregate of 2 million common shares at $2.60 per share in an offering made from its currently effective shelf registration. "The net proceeds of this investment will help support the continued development of our new product pipeline and provide additionalfunding for selected strategic in-licensing opportunities that may arise," commented Leonard P. Shaykin, Chairman and Chief Executive Officer. About NaPro BioTherapeutics NaPro BioTherapeutics, Inc., is a life science company focused on the development of therapies for the treatment of cancer and hereditary disease. Forward Looking Statements The statements in this press release that are not historical facts are forward-looking statements that represent management's beliefs and assumptions as of the date hereof, based on currently available information. Forward-looking statements can be identified by the use of words such as "believes," "intends," "estimates," "may," "will," "should," "anticipates," "expected" or comparable terminology or by discussions of strategy. Although the Company believes that the expectations reflected in such forward-looking statements are reasonable, it cannot assure that these expectations will prove to be correct. Such statements involve risks and uncertainties including those factors identified under the captions "Risk Factors," "Special Note Regarding Forward Looking Statements" or "Cautionary Note Regarding Forward Looking Statements" in the Company's documents filed from time to time with the SEC, including the Company's Current Report on Form 8-K/A, dated February 11, 2004, and its Annual Report on Form 10-K for the year ending December 31, 2003 filed with the SEC on March 11, 2004. Should one or more of these risks materialize (or the consequences of such a development worsen), or should the underlying assumptions prove incorrect, actual results could differ materially from those forecasted or expected. The Company disclaims any intention or obligation to update publicly or revise such statements whether as a result of new information, future events or otherwise. For further information, please contact L. Robert Cohen, Vice President, Investor Relations of NaPro BioTherapeutics, Inc., +1-212-218-8715. DATASOURCE: NaPro BioTherapeutics, Inc. CONTACT: L. Robert Cohen of NaPro BioTherapeutics, Vice President, Investor Relations, +1-212-218-8715; Investors, Lilian Stern of Stern Investor Relations, Inc., +1-212-362-1200, or Media, Peter Steinerman +1-516-374-3031, for NaPro BioTherapeutics Web site: http://www.naprobio.com/

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