TIDMTRX
RNS Number : 6534U
Tissue Regenix Group PLC
17 October 2014
Tissue Regenix presents initial clinical trial results from
study into efficacy of DermaPure(TM) dermal allograft on acute
wounds
Presentation to be made by Tissue Regenix Senior Director of
Clinical Affairs (Patti Gary) and clinical trial leader Dr Ardeshir
Bayat, from the University Hospital of South Manchester NHS
Foundation Trust, at The Symposium on Advanced Wound Care (SAWC) in
Las Vegas
YORK, 17 October 2014 - Tissue Regenix Group plc (AIM:TRX)
("Tissue Regenix" or "the Group"), the regenerative medical devices
company, is presenting the initial results from the clinical study
into the efficacy of its DermaPure(TM) dermal allograft on acute
wounds at The Symposium on Advanced Wound Care (SAWC) in Las
Vegas.
Key facts:
-- DermaPure(TM) showed improved healing over control with
elevated levels of key markers associated with wound healing.
-- Acute wounds represent an expansion of the potential
applications for DermaPure(TM) with surgical wounds accounting for
over 60% of all wounds by type(1) .
Tissue Regenix Senior Director of Clinical Affairs (Patti Gary)
and clinical trial leader Dr Ardeshir Bayat from the University
Hospital of South Manchester NHS Foundation Trust, will update the
conference on the initial results from the clinical study on
patients with acute wounds treated with DermaPure(TM). The
presentation will take place at 7am on Saturday 18(th) October,
2014.
The clinical study has been conducted by the University Hospital
of South Manchester NHS Foundation Trust and involved a series of
six-week trials on 50 healthy human patients, to investigate the
responsiveness of acute wounds to Tissue Regenix's DermaPure(TM)
dermis matrix, and to clarify if DermaPure(TM) improves the closure
of acute wounds compared to "normal" wound healing techniques.
While the full findings are still to be peer reviewed and
verified, initial results will be presented at the SAWC conference
and these early findings suggest that:
-- DermaPure(TM) has resulted in increased angiogenesis (the
growth of new blood vessels to aid wound care) compared to the
control sample
-- Results of the study suggest that DermaPure(TM) was the only
tissue product observed that showed elevated mRNA expression of
PROK2 and MT6-MMP - suggesting that the dCELL matrix could improve
cellular level healing compared to the control sample
The global wound care market is expected to reach $18.3bn by
2019 according to new research published by MarketsandMarkets(2)
this month, growing at a CAGR of 3.2% from 2014 to 2018.
Acute wounds that Tissue Regenix hopes could be treated
successfully with DermaPure(TM) include surgical incisions and
traumatic injuries such as lacerations, abrasions, avulsions,
penetrations, bites or burn injuries. Surgical wounds were the
largest category of wounds according to MedMarket Diligence, with a
global incidence of 110.3 million in 2009 with a projected CAGR of
3.6%(3) .
Results from the clinical trial into the efficacy of
DermaPure(TM) in treating chronic wounds (announced on 21 October
2013 and conducted by Dr Bayat and his team at the University
Hospital of South Manchester)(4) will also be showcased at the SAWC
meeting.
This earlier study showed that patients who have had chronic
wounds for an average of 4 1/2 years and who were treated with a
single application of DermaPure(TM) saw an 87% reduction in the
size of all wounds, while 60% of patients were completely healed,
with virtually no recurrences.
Currently in the US, 6.5 million patients are afflicted by
chronic wounds. Tissue Regenix is targeting the existing $1.4bn
market for wound healing devices and equipment, which is
anticipated to reach $1.5bn by 2016([5]) .
The SAWC convention is run by the Association of Advanced Wound
Care and is one of the most prestigious healthcare conferences in
the US, bringing scientists and healthcare professionals around the
world together to showcase the latest wound care developments.
Greg Bila, President of Tissue Regenix Wound Care Inc. said:
"The US acute and chronic wound care market represents a major
commercial opportunity for Tissue Regenix and we are delighted to
be able to showcase the initial results from the acute wound trial
and the results from the earlier chronic wound care clinical trial
at the prestigious Symposium on Advanced Wound Care."
"Commercialisation of DermaPure(TM) continues to progress
according to plan. We are working to gain further hospital product
evaluation committee approvals as a trigger for future product
adoption. We are also progressing in the enrolment of patients into
human trials in the US. We look forward to discussions at SAWC as
an opportunity to reach an even larger audience of US and global
healthcare leaders."
DermaPure(TM) works by taking human donor skin and removing the
DNA and cells, using Tissue Regenix's patented dCELL(R) process to
leave a natural biological scaffold that can be placed in the wound
to aid natural healing by attracting the patient's own cells to the
wound area.
- Ends -
References
(1) MedMarket Diligence LLC 2009
(2) Wound Care Market by Type (Traditional (Wound Closure,
Anti-infective), Basic (Films, Cleansing), Advanced (Hydrogels,
Hydrocolloids, Alginate, Collagen), Active (Artificial Skin &
Skin Substitutes), Pressure Relief Devices, NPWT) - Global Forecast
to 2019: MarketandMarkets.com
(3) MedMarket Diligence, LLC, Worldwide Wound Management,
Forecast to 2017: Established and Emerging Products, Technologies
and Markets in the U.S., Europe, Japan and Rest of World (September
2009)
(4) Wound Repair and Reneneration, 17 October, 2013:
'Single-stage application of a novel decellularized dermis for
treatment-resistant lower limb ulcers: Positive outcomes assessed
by SIAscopy, laser perfusion, and 3D imaging, with sequential timed
histological analysis' NS Greaves, B Benatar, M Baguneid, A
Bayat
(5) 'Wounds, gauzes and biofilms combine for an ugly triad' JG
Thomas, L Corum, H Mantlagh (2012)
For Further Information
Tissue Regenix Wound Care Inc: +1 210 347 8302
Greg Bila
Tissue Regenix Group Plc: +44 19 0443 5176
Antony Odell
Jefferies International Ltd: +44 20 7029 8000
Simon Hardy
Harry Nicholas
Newgate Communications: +44 207 6806550
Andrew Adie
Deborah Saw
About Tissue Regenix
Tissue Regenix is a leading medical devices company in the field
of regenerative medicine. The company's patented decellularisation
('dCELL(R)') technology removes DNA and other cellular material
from animal and human tissue leaving an acellular tissue scaffold
which is not rejected by the patient's body which can then be used
to repair diseased or worn out body parts. The potential
applications of this process are diverse and address many critical
clinical needs such as vascular disease, heart valve replacement
and knee repair.
Tissue Regenix was formed in 2006 when it was spun-out from the
University of Leeds. The company commercialises academic research
conducted by our partners around the World.
In November 2012 Tissue Regenix Group plc set up a subsidiary
company in the United States- 'Tissue Regenix Wound Care Inc.', as
part of its commercialisation strategy for its dCELL(R) technology
platform.
This information is provided by RNS
The company news service from the London Stock Exchange
END
MSCMRBITMBJBBTI
Tissue Regenix (LSE:TRX)
Historical Stock Chart
From Aug 2024 to Sep 2024
Tissue Regenix (LSE:TRX)
Historical Stock Chart
From Sep 2023 to Sep 2024