UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

NOTICE OF EFFECTIVENESS

Effective Date: February 13, 2013
Accession Number: 0001144204-13-006488
Submission Type: POS AM
CIK: 0001072379
Company Name: NORTHWEST BIOTHERAPEUTICS INC
File Number: 333-182470
Northwest Biotherapeutics (QB) (USOTC:NWBO)
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