South Africa Rolls Out J&J Covid-19 Vaccine to Healthcare Workers
February 17 2021 - 7:53AM
Dow Jones News
By Gabriele Steinhauser
JOHANNESBURG -- South Africa started administering Johnson &
Johnson's Covid-19 vaccine, which has yet to be authorized
anywhere, to healthcare workers, as the country grapples with a
new, more contagious coronavirus strain.
The South African government scrambled to secure the J&J
shots after halting a planned rollout of a vaccine developed by
AstraZeneca and the University of Oxford earlier this month. That
followed results from a small clinical trial in South Africa that
found the AstraZeneca vaccine didn't appear to protect recipients
from developing mild or moderateillness from the fast-spreading new
strain of the coronavirus first detected in the country.
The J&J vaccine was found to be 57% effective at preventing
moderate and severe Covid-19 symptoms in a larger trial held in
South Africa, including from the B.1.351 variant, which has become
the predominant version there. That was lower than the 72% efficacy
rate observed during J&J's trial in the U.K., which vaccine
experts attributed to the South African variant's ability to
partially escape the immune response triggered by some Covid-19
vaccines.
When looking at just severe Covid-19 cases, the J&J vaccine
was found to be 85% effective, including in South Africa.
"The Johnson & Johnson vaccine has been shown in extensive
trials to be safe and efficacious and will protect our healthcare
workers from illness and death from Covid-19," said South African
President Cyril Ramaphosa, who got the shot, alongside healthcare
workers, at a public hospital in a Cape Town township hit hard by
the virus. Mr. Ramaphosa, who is 68 years old, said he wanted to
show South Africans that the vaccine was safe.
South Africa's drug regulator cleared the J&J rollout as
part of an "implementation study" that will continue while it
reviews the company's application for full authorization. In
contrast to other Covid-19 vaccines in use, the J&J vaccine
requires just a single dose, making it much easier to distribute
and administer, especially in developing countries.
South Africa has been the African country hit hardest by the
pandemic, recording 1.49 million cases and 48,313 deaths so far.
But excess deaths have reached more than 137,000 since the virus
first took hold in the country, suggesting a much larger toll.
Late in 2020, scientists detected a new strain, which they say
is more contagious and appears to be resistant to antibodies
triggered by an earlier Covid-19 infection and some vaccines. The
strain has since spread to 40 countries, including the U.S., but is
believed to be relatively rare outside the Southern African
region.
Vaccine experts, including those at the World Health
Organization, say they are optimistic that the AstraZeneca vaccine
can still prevent severe cases of Covid-19, as well as
hospitalizations and deaths, from the variant.
South Africa, which has a population of 60 million people, has
received a first delivery of 80,000 doses of the J&J vaccine
and has ordered a total of 9 million doses.
The U.S. Food and Drug Administration is reviewing J&J's
application and is expected to make a ruling later in February.
Write to Gabriele Steinhauser at
gabriele.steinhauser@wsj.com
(END) Dow Jones Newswires
February 17, 2021 07:38 ET (12:38 GMT)
Copyright (c) 2021 Dow Jones & Company, Inc.
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