The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

  UNITED STATES SECURITIES AND EXCHANGE COMMISSION OMB APPROVAL
 Washington, D.C. 20549
FORM 13F		OMB Number:   3235-0006
Expires:          July 31, 2015
Estimated average burden
hours per response:       23.8


FORM 13F COVER PAGE


Report for the Calendar Year or Quarter Ended:
09-30-2022
 
Check here if Amendment:      Amendment Number:
 
This Amendment (Check only one.):    is a restatement.
     adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:JANUS HENDERSON GROUP PLC 
Address:201 BISHOPSGATE 
 LONDON X0 EC2M 3AE 

Form 13F File Number:  028-10904 


The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:

Name:Kristin Mariani 
Title:Head of North America Compliance 
Phone: 303-333-3863 

Signature, Place, and Date of Signing:

/s/ Kristin Mariani Denver,  COLORADO 11-14-2022 
[Signature][City, State][Date]

Do you wish to provide information pursuant to Special Instruction 5?        Yes      X  No

Report Type (Check only one.):

     13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)

     13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)

X  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


List of Other Managers Reporting for this Manager
[If there are no entries in this list, omit this section.]

Form 13F File NumberName
028-04211 INTECH INVESTMENT MANAGEMENT LLC 

Form 13F Summary Page

Report Summary:

Number of Other Included Managers:15 
Form 13F Information table Entry Total:6414 
Form 13F Information table Value Total:133,577,018 
 (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F number(s) of all institutional investement managers with respect to which this report is filed, other than the manager filing this report.

   No.Form 13F File NumberNameCIK
39 028-06487 FIRST TRUST ADVISORS LP 0001125816 
10 028-01343 JANUS HENDERSON INVESTORS US LLC 0000812295 
11 028-20157 Janus Henderson Investors (Australia) Institutional Funds Management Ltd 0001794678 
12 028-20257 Janus Henderson Investors (Singapore) Ltd 0001810753 
16 028-21345 Janus Henderson Investors (Jersey) Ltd 0001874815 
30 028-14633 Equitable Investment Management Group, LLC 0001536185 
31 028-16979 Park Avenue Institutional Advisers LLC 0001640801 
32 028-10998 GuideStone Capital Management, LLC 0001308668 
33 028-06325 NEW YORK LIFE INVESTMENT MANAGEMENT LLC 0001133639 
34 028-05161 Nationwide Fund Advisors 0001097218 
35 028-00290 NORTHERN TRUST CORP 0000073124 
36 028-14003 Pacific Life Fund Advisors LLC 0001499091 
37 028-18923 Penn Mutual Asset Management, LLC 0000855702 
38 028-16475 SEI INVESTMENTS MANAGEMENT CORP 0000907692 
4 028-10906 JANUS HENDERSON INVESTORS UK Ltd 0001280110 
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