Merck, AstraZeneca Get Green Light for Advanced Ovarian Cancer Treatment
May 08 2020 - 6:37PM
Dow Jones News
By Kimberly Chin
Merck & Co. and AstraZeneca PLC said the U.S. Food and Drug
Administration approved the use of Lynparza, an ovarian cancer
treatment in combination with another drug, as a first-line
maintenance treatment for adults with an advanced stage of ovarian
cancer.
The Phase 3 study of Lynparza in combination with bevacizumab
has shown a reduced risk of the disease progressing or death by
67%. It improved progression-free survival to a median of 37.2
months compared with 17.7 months with the use of bevacizumab
alone.
The patients who were tested have advanced epithelial ovarian,
fallopian tube or primary peritoneal cancer and are in complete or
partial response to a first-line platinum-based chemotherapy. Their
cancer is also associated with homologous recombination deficiency
(HRD) positive status, Merck said.
About one in two women with advanced ovarian cancer have an
HRD-positive tumor, the company said.
The combination treatment is undergoing regulatory reviews in
the European Union, Japan and other countries, Merck said.
Write to Kimberly Chin at kimberly.chin@wsj.com
(END) Dow Jones Newswires
May 08, 2020 18:22 ET (22:22 GMT)
Copyright (c) 2020 Dow Jones & Company, Inc.
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