AXP American Express Company

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES                                                                                   
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940                       

1. Name and Address of Reporting Person * Pickett Denise	2. Issuer Name and Ticker or Trading Symbol AMERICAN EXPRESS CO [ AXP ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                    _____ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) Pres., GSG and TLS
(Last)          (First)          (Middle) 200 VESEY STREET, AMERICAN EXPRESS TOWER	3. Date of Earliest Transaction (MM/DD/YYYY) 4/30/2021
(Street) NEW YORK, NY 10285-5001 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	4/30/2021		A(1)		5260	A	$154.63	20904.83	D
Common Stock	4/30/2021		F(2)		2800	D	$154.63	18104.83	D
Common Stock	4/30/2021		M		5260	A	$98.75	23364.83	D
Common Stock	4/30/2021		S(3)		5260	D	$153.11 (4)	18104.83 (5)	D
Common Stock								1389.7637 (6)	I	by ESOP

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (Right to Buy)	$98.75	4/30/2021		A (7)		5260		4/30/2021	4/30/2028	Common Stock	5260	$0	5260	D
Employee Stock Option (Right to Buy)	$98.75	4/30/2021		M			5260	4/30/2021	4/30/2028	Common Stock	5260	$0	0	D

Explanation of Responses:
(1)	Represents shares acquired pursuant to vesting of Restricted Stock Units that were granted to the reporting person in April 2018 and have vested based on the Company's 2018-20 average return on equity performance.
(2)	The reported disposition represents the surrender of shares to satisfy tax obligations arising from the vesting of Restricted Stock Units.
(3)	The reported disposition represents the sale of shares to cover the cost of exercise and withholding tax obligations arising from the stock option exercise reported above and the sale of the net shares acquired from this exercise.
(4)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $153.10 to $153.12. The reporting person undertakes to provide to American Express Company, any security holder of American Express Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within this range.
(5)	Includes shares acquired pursuant to dividend reinvestment.
(6)	Shares held in reporting person's account under the Company's Employee Stock Ownership Plan.
(7)	The reported acquisition represents the vesting of Stock Options that were granted to the reporting person in April 2018. These options became exercisable on April 30, 2021.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Pickett Denise 200 VESEY STREET, AMERICAN EXPRESS TOWER NEW YORK, NY 10285-5001			Pres., GSG and TLS

Signatures
/s/ Kristina V. Fink, attorney-in-fact		5/4/2021
**Signature of Reporting Person		Date