FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Galer Bradley S.
2. Issuer Name and Ticker or Trading Symbol

ZOGENIX, INC. [ ZGNX ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
EVP/Chief Medical Officer
(Last)          (First)          (Middle)

C/O ZOGENIX, INC., 5959 HORTON STREET, SUITE 500
3. Date of Earliest Transaction (MM/DD/YYYY)

3/15/2021
(Street)

EMERYVILLE, CA 94608
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 3/15/2021  M  1562 (1)A$0 19609 (2)D  
Common Stock 3/15/2021  F  438 (3)D$20.70 19171 D  
Common Stock 3/15/2021  M  2031 (4)A$0 21202 D  
Common Stock 3/15/2021  F  569 (5)D$20.70 20633 D  
Common Stock 3/15/2021  M  1625 (6)A$0 22258 D  
Common Stock 3/15/2021  F  455 (7)D$20.70 21803 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Restricted Stock Units  (8)3/15/2021  M     1562   (9) (10)Common Stock 1562.0 $0 1562 D  
Restricted Stock Units  (8)3/15/2021  M     2031   (11) (10)Common Stock 2031.0 $0 4062 D  
Restricted Stock Units  (8)3/15/2021  M     1625   (12) (10)Common Stock 1625.0 $0 4875 D  

Explanation of Responses:
(1) Represents vesting of one-fourth (1/4) of restricted stock units granted on March 15, 2018.
(2) Includes 845 shares acquired under the Company's Employee Stock Purchase Plan since the last Section 16 filing by the Reporting Person.
(3) Represents shares withheld to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock units described in footnote 1.
(4) Represents vesting of one-fourth (1/4) of restricted stock units granted on March 22, 2019.
(5) Represents shares withheld to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock units described in footnote 4.
(6) Represents vesting of one-fourth (1/4) of restricted stock units granted on March 4, 2020.
(7) Represents shares withheld to satisfy tax withholding obligations in connection with the vesting of shares of restricted stock units described in footnote 6.
(8) Each restricted stock unit represents a contingent right to receive one share of Zogenix common stock.
(9) The restricted stock units vests in four equal installments on each of March 15, 2019, 2020, 2021 and 2022, subject to the reporting person's continuous service to the Company on such vesting date.
(10) Not applicable.
(11) The restricted stock units vests in four equal installments on each of March 15, 2020, 2021, 2022 and 2023, subject to the reporting person's continuous service to the Company on such vesting date.
(12) The restricted stock units vests in four equal installments on each of March 15, 2021, 2022, 2023 and 2024, subject to the reporting person's continuous service to the Company on such vesting date.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Galer Bradley S.
C/O ZOGENIX, INC.
5959 HORTON STREET, SUITE 500
EMERYVILLE, CA 94608


EVP/Chief Medical Officer

Signatures
/s/ Thomas Doyle, Attorney-in-fact for Bradley Galer3/17/2021
**Signature of Reporting PersonDate

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