WSBC WesBanco Inc

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES                                                                                   
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940                       

1. Name and Address of Reporting Person * Dargusch Jonathan D	2. Issuer Name and Ticker or Trading Symbol WESBANCO INC [ WSBC ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                    _____ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) EVP - Wealth Management
(Last)          (First)          (Middle) C/O WESBANCO, INC., ONE BANK PLAZA	3. Date of Earliest Transaction (MM/DD/YYYY) 5/25/2021
(Street) WHEELING, WV 26003 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	5/25/2021		M		2250	A	$32.37	28308.345	D
Common Stock	5/25/2021		M		1125	A	$21.55	29433.345	D
Common Stock	5/25/2021		M		2000	A	$31.58	31433.345	D
Common Stock	5/25/2021		S		2250	D	$38.7465	29183.345	D
Common Stock	5/25/2021		S		1125	D	$38.6136	28058.345	D
Common Stock	5/25/2021		S		2000	D	$38.5436	26058.345	D
Common Stock								998.605	I	by KSOP
Common Stock								725	I	Custodian for Grandchildren

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option	$32.37	5/25/2021		M			2250	(1)	5/25/2023	Common Stock	2250	$0	0	D
Stock Option	$21.55	5/25/2021		M			1125	(2)	5/27/2027	Common Stock	1125	$0	1125	D
Stock Option	$31.58	5/25/2021		M			2000	(3)	6/2/2022	Common Stock	2000	$0	0	D

Explanation of Responses:
(1)	Options vested in 2 equal installments beginning 12/31/16.
(2)	Options vest in 2 equal installments beginning 12/31/20.
(3)	Options vested in equal installments beginning 12/31/2015.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Dargusch Jonathan D C/O WESBANCO, INC. ONE BANK PLAZA WHEELING, WV 26003			EVP - Wealth Management

Signatures
/s/ Robert H. Young, Attorney-in-Fact		5/26/2021
**Signature of Reporting Person		Date