FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                       
1. Name and Address of Reporting Person * Frieberg Jacob B. 2. Issuer Name and Ticker or Trading Symbol VACCINEX, INC. [ VCNX ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)__X__ Director                    _____ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)
C/O VACCINEX, INC., 1895 MOUNT HOPE AVENUE		 3. Date of Earliest Transaction (MM/DD/YYYY)
5/12/2022
(Street)
ROCHESTER, NY 14620
(City)        (State)        (Zip)
 4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
 6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock                 63519  D   
Common Stock                 94510  I  By Benbow Estates, Ltd. (1)
Common Stock                 4121  I  By Gee Eff Services Limited (2)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)  $13.60                   (3) 9/15/2027  Common Stock  6396    6396  D   
Stock Option (Right to Buy)  $5.26                   (3) 3/30/2029  Common Stock  2501    2501  D   
Stock Option (Right to Buy)  $7.78                   (3)  (4) Common Stock  7718    7718  D   
Stock Option (Right to Buy)  $5.52                   (3) 6/29/2029  Common Stock  2385    2385  D   
Stock Option (Right to Buy)  $7.17                   (3) 9/27/2029  Common Stock  1856    1856  D   
Stock Option (Right to Buy)  $4.85                   (3) 12/28/2029  Common Stock  2737    2737  D   
Stock Option (Right to Buy)  $4.00                   (3) 3/29/2030  Common Stock  3336    3336  D   
Stock Option (Right to Buy)  $3.95                   (3)  (5) Common Stock  15679    15679  D   
Stock Option (Right to Buy)  $3.61                   (3) 6/28/2030  Common Stock  3756    3756  D   
Stock Option (Right to Buy)  $1.78                   (3) 9/28/2030  Common Stock  7626    7626  D   
Stock Option (Right to Buy)  $2.07                   (3) 12/29/2030  Common Stock  6545    6545  D   
Stock Option (Right to Buy)  $2.98                   (3) 3/31/2031  Common Stock  4535    4535  D   
Stock Option (Right to Buy)  $2.15                  5/11/2022   (6) Common Stock  28586    28586  D   
Stock Option (Right to Buy)  $2.8                   (3) 6/28/2031  Common Stock  4804    4804  D   
Stock Option (Right to Buy)  $2.16                   (3) 9/28/2031  Common Stock  6233    6233  D   
Stock Option (Right to Buy)  $1.04                   (3) 12/29/2031  Common Stock  12856    12856  D   
Stock Option (Right to Buy)  $1.32                   (3) 3/28/2032  Common Stock  10032    10032  D   
Stock Option (Right to Buy)  $1.12  5/12/2022    A     53254      5/12/2023   (7) Common Stock  53254  $0  53254  D   

Explanation of Responses:
(1)  Mr. Frieberg's spouse is the owner of Benbow Estates, Ltd. and Mr. Frieberg is an officer of Benbow Estates, Ltd. Mr. Frieberg disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.
(2)  Mr. Frieberg is the sole owner and President of Gee Eff Services Limited.
(3)  Exercisable in full as of the date of this report.
(4)  This option expires on May 14, 2029 or five years following retirement or cessation of services, whichever occurs first.
(5)  This option expires on May 12, 2030 or five years following retirement or cessation of services, whichever occurs first.
(6)  This option expires on May 9, 2031 or five years following retirement or cessation of services, whichever occurs first.
(7)  This option was granted pursuant to the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and expires on May 9, 2032 or five years following retirement or cessation of services, whichever occurs first.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Frieberg Jacob B.
C/O VACCINEX, INC.
1895 MOUNT HOPE AVENUE
ROCHESTER, NY 14620		 X



Signatures
/s/ Scott E. Royer, Attorney-in-Fact for Jacob B. Frieberg 5/13/2022
**Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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