UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No.)

Simmons First National Corporation
(Name of Issuer)

Common Stock
(Title of Class of Securities)

828730200
(CUSIP Number)

December 31, 2020
(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule
pursuant to which this Schedule is filed:

X Rule 13d-1(b) Rule 13d-1(c) Rule 13d-1(d)

------------------------------------------------------------------
CUSIP   828730200


Page    2    of    6    Pages



  1

Names of Reporting Persons
S.S. or I.R.S. Identification No. of above person
        Northern Trust Corporation                      36-2723087
        The Northern Trust Company                      36-1561860


  2

Check the appropriate box if a member of a group

        Not Applicable  (a)     [ ]
                        (b)     [ ]



  3

S.E.C. use only



  4

Citizenship or place of organization

        Northern Trust Corporation - a Delaware corporation




Number of Shares Beneficially owned by Each Reporting Person with

  5
Sole Voting Power

        185,235


  6
Shared Voting Power

        6,085,645


  7
Sole Dispositive Power

        1,481,877


  8
Shared Dispositive Power

        5,405,187


  9

Aggregate amount beneficially owned by each reporting person

        7,079,103


10

Check box if the aggregate amount in Row (9) excludes certain shares.




11

Percent of class represented by amount in Row 9

        6.5



12

Type of reporting person


        Northern Trust Corporation      HC
        The Northern Trust Company      BK
------------------------------------------------------------------

SECURITIES AND EXCHANGE COMMISSION
Washington, DC  20549

SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934

Check the following box if a fee is being paid with statement [ ].

1.      (a)     Simmons First National Corporation
                (Name of Issuer)

        (b)     501 Main Street, Pine Bluff, Arkansas 71601
                (Address of Issuer's Principal Executive Office)

2.      (a)     Northern Trust Corporation
                (Name of Person Filing)

        (b)     50 South LaSalle Street, Chicago, Illinois 60603
                (Address of Person Filing)

        (c)     Delaware Corporation
                (Citizenship)

        (d)     Common Stock
                (Title of Class of Securities)

        (e)     828730200
                (CUSIP Number)

3. This statement is being filed by Northern Trust Corporation as a
Parent Holding Company in accordance with S240.13d-1(b) (1) (ii) (G).

4.      (a)      7,079,103
                (Amount Beneficially Owned)

        (b)      6.5
                (Percent of Class)

        (c)     Number of shares as to which such person has:

                (i)           185,235
                        (Sole Power to Vote or to Direct the Vote)

                (ii)          6,085,645
                        (Shared Power to Vote or to Direct the Vote)

                (iii)         1,481,877
                        (Sole Power to Dispose or Direct Disposition)

                (iv)         5,405,187
                        (Shared Power to Dispose or Direct Disposition)



5. If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
 5 percent of the class of securities, check the following:  [  ]

6. Statement regarding ownership of 5 percent or more on behalf of another
 person:

The securities are beneficially owned by Northern Trust
Corporation and its subsidiaries, such as The Northern Trust Company,
in their various fiduciary capacities.


7.      Parent Holding Company reporting on behalf of the following subsidiaries,
 all of which are banks as defined in Section 3(a) (6) of the Act:

        The Northern Trust Company
        50 South LaSalle Street
        Chicago, IL  60603


8.      Identification and Classification of Members of the Group.

Not Applicable.

9.      Notice of Dissolution of Group.

Not Applicable.

10. By signing below I certify that, to the best of my knowledge and belief,
 the securities referred to above were acquired in the ordinary course of
business and were not acquired for the purpose of and do not have the effect
of changing or influencing the control of the issuer of such securities and
were not acquired in connection with or as a participant in any transaction
having such purpose or effect.





        After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.


                                                                NORTHERN TRUST CORPORATION

                                                                ________________________________
                                                                By:  Robert P Browne
                                                                As its Executive Vice President
DATED:  02-09-2021
-----------------------------------------------------------------------------

EXHIBIT TO SCHEDULE 13G
FILED BY NORTHERN TRUST CORPORATION

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC  20549-1004
Attention: Filing Desk, Stop 1-4

RE:  Simmons First National Corporation

Pursuant to the requirement of 240.13d-1(k) (1) (iii), this exhibit shall
constitute our written agreement that the Schedule 13G to which this
exhibit is attached is filed on behalf of Northern Trust Corporation and of
its subsidiary(ies), as stated below, regarding our respective beneficial
ownership in the above-captioned equity security.
                                                        NORTHERN TRUST CORPORATION

                                                        _________________________________
                                                        By:  Robert P Browne
                                                        As its Executive Vice President


DATED:  02-09-2021

THE NORTHERN TRUST COMPANY



________________________________________
By:  Robert P Browne
As its Executive Vice President

Simmons First National (NASDAQ:SFNC)
Historical Stock Chart
From Feb 2024 to Mar 2024 Click Here for more Simmons First National Charts.
Simmons First National (NASDAQ:SFNC)
Historical Stock Chart
From Mar 2023 to Mar 2024 Click Here for more Simmons First National Charts.