Statement of Changes in Beneficial Ownership (4)

FORM 4 [X] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* Vivo Opportunity, LLC	2. Issuer Name and Ticker or Trading Symbol Sierra Oncology, Inc. [ SRRA ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) 192 LYTTON AVENUE	3. Date of Earliest Transaction (MM/DD/YYYY) 7/1/2022
(Street) PALO ALTO, CA 94301 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	7/1/2022		D		161712	D⁽²⁾	$55.00	0	I	By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. ⁽¹⁾
Common Stock	7/1/2022		D		2735853	D⁽²⁾	$55.00	0	I	By: Vivo Opportunity Fund Holdings, L.P. ⁽³⁾
Common Stock	7/1/2022		D		431947	D⁽²⁾	$55.00	0	I	By: Vivo Capital Fund IX, L.P. ⁽⁴⁾

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Series A Warrants	$13.20	7/1/2022		D	⁽⁵⁾		324740 ⁽²⁾	11/13/2019	11/13/2024	Common Stock	324740	$0.00 ⁽⁴⁾	0	I	By: Vivo Capital Fund IX, L.P. ⁽⁴⁾
Series A Warrants	$13.20	7/1/2022		D	⁽⁵⁾		1455384 ⁽²⁾	11/13/2019	11/13/2024	Common Stock	1455384	$0.00 ⁽⁴⁾	0	I	By: Vivo Opportunity Fund Holdings, L.P. ⁽³⁾
Series A Warrants	$13.20	7/1/2022		D	⁽⁵⁾		75749 ⁽²⁾	11/13/2019	11/13/2024	Common Stock	75749	$0.00 ⁽⁴⁾	0	I	By: Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. ⁽¹⁾

Explanation of Responses:
(1)	Vivo Ventures VII, LLC ("Vivo Ventures LLC") is the general partner of each of Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P. ("Vivo Fund VII"), the record holder of the securities. Vivo Ventures LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.
(2)	Pursuant to an Agreement and Plan of Merger, dated April 12, 2022, between GlaxoSmithKline plc ("GSK"), Orikum Acquisition Inc. ("Merger Sub") and the Issuer (the "Merger Agreement"), Merger Sub merged with and into the Issuer on July 1, 2022, with the Issuer surviving as a wholly-owned subsidiary of GSK (the "Merger"). At the effective time of the Merger, each outstanding share of common stock of the Issuer automatically and without any required action on the part of the Reporting Person, was converted into the right to receive $55.00 in cash, without interest.
(3)	Vivo Opportunity, LLC ("Vivo Opportunity LLC") is the general partner of Vivo Opportunity Fund Holdings, L.P., the record holder of the securities. Vivo Opportunity LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.
(4)	Vivo Capital IX, LLC ("Vivo Capital IX LLC") is the general partner of Vivo Capital Fund IX, L.P., the record holder of the securities. Vivo Capital IX LLC disclaims beneficial ownership over such securities except to the extent of its pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purposes.
(5)	Pursuant to the terms of the Merger Agreement, the Issuer's outstanding Series A Warrants (the "Series A Warrants") were treated in accordance with their respective terms such that, at the effective time of the Merger, the outstanding Series A Warrants were cancelled and thereafter represent only the right to receive an amount in cash, without interest, equal to the Black Scholes Value (as defined in the Series A Warrants), which as calculated under the terms of the Series A Warrants equaled $45.98 per share of common stock underlying such warrants.

Remarks:
Gaurav Aggarwal has been deputized to represent the Reporting Persons on the board of directors of the Issuer. By virtue of Dr. Aggarwal's representation, for purposes of Section 16 of the Securities Exchange Act of 1934 each of the Reporting Persons may be deemed directors by deputization of the Issuer. Dr. Aggarwal has filed a separate Section 16 report disclosing securities of the Issuer that he may be deemed to beneficially own for Section 16 purposes.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Vivo Opportunity, LLC 192 LYTTON AVENUE PALO ALTO, CA 94301	X	X
Vivo Opportunity Fund Holdings, L.P. 192 LYTTON AVENUE PALO ALTO, CA 94301	X	X
Vivo Capital IX, LLC 192 LYTTON AVENUE PALO ALTO, CA 94301	X	X
Vivo Capital Fund IX, L.P. 192 LYTTON AVENUE PALO ALTO, CA 94301	X	X
VIVO VENTURES VII, LLC 192 LYTTON AVENUE PALO ALTO, CA 94301	X	X
Vivo Ventures Fund VII, L.P. 192 LYTTON AVENUE PALO ALTO, CA 94301	X	X
Vivo Ventures VII Affiliates Fund, L.P. 192 LYTTON AVENUE PALO ALTO, CA 94301	X	X

Signatures
/s/ Gaurav Aggarwal as a managing member of Vivo Opportunity, LLC		7/1/2022
^**Signature of Reporting Person		Date
/s/ Gaurav Aggarwal as a managing member of Vivo Opportunity, LLC, the general partner of Vivo Opportunity Fund Holdings, L.P.		7/1/2022
^**Signature of Reporting Person		Date
/s/ Frank Kung as a managing member of Vivo Capital IX, LLC		7/1/2022
^**Signature of Reporting Person		Date
/s/ Frank Kung as a managing member of Vivo Capital IX, LLC, the general partner of Vivo Capital Fund IX, L.P.		7/1/2022
^**Signature of Reporting Person		Date
/s/ Frank Kung as a managing member of Vivo Ventures VII, LLC		7/1/2022
^**Signature of Reporting Person		Date
/s/ Frank Kung as a managing member of Vivo Ventures VII, LLC, the general partner of Vivo Ventures Fund VII, L.P. and Vivo Ventures VII Affiliates Fund, L.P.		7/1/2022
^**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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