FORM 4
[X] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Longitude Capital Partners III, LLC		 2. Issuer Name and Ticker or Trading Symbol

Sierra Oncology, Inc. [ SRRA ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                    __X__ 10% Owner
_____ Officer (give title below)    _____ Other (specify below)
(Last)          (First)          (Middle)

2740 SAND HILL ROAD, SECOND FLOOR		 3. Date of Earliest Transaction (MM/DD/YYYY)

4/27/2022
(Street)

MENLO PARK, CA 94025
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

___ Form filed by One Reporting Person
_ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 4/27/2022  J(1)  175000 D$0.00 0 I See footnote (2)
Common Stock 4/27/2022  J(3)  1964771 D$0.00 0 I See footnote (4)
Common Stock 4/27/2022  J(5)  5023 A$0.00 5023 I See footnote (6)
Common Stock 4/27/2022  J(5)  2152 A$0.00 2152 I See footnote (7)
Common Stock 4/27/2022  J(5)  7175 A$0.00 7175 I See footnote (8)
Common Stock 4/27/2022  J(9)  588 A$0.00 5611 I See footnote (6)
Common Stock 4/27/2022  J(9)  252 A$0.00 2404 I See footnote (7)
Common Stock 4/27/2022  J(9)  840 A$0.00 8015 I See footnote (8)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
(1) Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Prime Fund, L.P. ("LPF") to its general and limited partners.
(2) The securities are held directly by LPF. Longitude Prime Partners, LLC ("LPP"), the general partner of LPF, may be deemed to have voting and investment power with respect to the shares held by LPF. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LPP and may be deemed to share voting, investment and dispositive power over such securities. Each of LPP, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such shares except to the extent of their respective pecuniary interests therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.
(3) Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Venture Partners III, L.P. ("LVP III") to its general and limited partners.
(4) These securities are held directly by LVP III. Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting, investment and dispositive power with respect to such securities. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP III and may be deemed to share voting, investment and dispositive power over such securities. Each of LCP III, Mr. Enright, and Ms. Tammenoms Bakker disclaim beneficial ownership over such securities except to the extent of their respective pecuniary interest therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.
(5) Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LCP III to its members.
(6) These shares are held directly by Juliet Tammenoms Bakker.
(7) These shares are held by a trust. Juliet Tammenoms Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Tammenoms Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.
(8) These shares are held directly by Patrick G. Enright.
(9) Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LPP to its members

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Longitude Capital Partners III, LLC
2740 SAND HILL ROAD
SECOND FLOOR
MENLO PARK, CA 94025
X

Longitude Venture Partners III, L.P.
2740 SAND HILL ROAD
SECOND FLOOR
MENLO PARK, CA 94025
X

Tammenoms Bakker Juliet
2740 SAND HILL ROAD
SECOND FLOOR
MENLO PARK, CA 94025
X

ENRIGHT PATRICK G
2740 SAND HILL ROAD
SECOND FLOOR
MENLO PARK, CA 94025
X

Longitude Prime Partners, LLC
2740 SAND HILL ROAD, SECOND FLOOR
MENLO PARK, CA 94025
X

Longitude Prime Fund, L.P.
2740 SAND HILL ROAD, SECOND FLOOR
MENLO PARK, CA 94025
X
Signatures
Longitude Venture Partners III, L.P.; By /s/ Patrick G. Enright, Managing Member of the general partner4/29/2022
**Signature of Reporting PersonDate

Longitude Capital Partners III, LLC; By /s/ Patrick G. Enright, Managing Member4/29/2022
**Signature of Reporting PersonDate

/s/ Juliet Tammenoms Bakker4/29/2022
**Signature of Reporting PersonDate

/s/ Patrick G. Enright4/29/2022
**Signature of Reporting PersonDate

Longitude Prime Partners, LLC, By: /s/ Patrick Enright, Managing Member4/29/2022
**Signature of Reporting PersonDate

Longitude Prime Fund, L.P., By: /s/ Patrick Enright, Managing Member of the general partner4/29/2022
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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