Nautilus Biotechnology, Inc. (NASDAQ: NAUT; or “Nautilus”), a company pioneering a single molecule proteome analysis platform, today reported financial results for the fourth quarter and fiscal year ended December 31, 2022.

Recent Highlights

  • Announced a strategic partnership with the Translational Genomics Research Institute (TGen) to explore the utility of the Nautilus platform for studying specific protein targets in diffuse intrinsic pontine glioma (DIPG), a rare and often fatal childhood cancer.
  • Presented a poster at the HUPO World Congress that demonstrated decoding of a model protein from an experiment of several dozen multi-affinity probes across 70 cycles.
  • Announced an expansion of Nautilus’ geographic footprint with the opening of an office in San Diego’s University Town Center, one of the largest and most talent-rich biotechnology and pharmaceutical hubs in the country.
  • Reported Q4 2022 expenses below peak spending levels reached in Q4 of the prior year, helping to maintain cash runway well into 2025.

“We made good progress on key scientific and business objectives in 2022 despite challenging macroeconomic conditions,” said Sujal Patel, CEO of Nautilus. “We presented scientific posters throughout the year that articulated key elements of our single-molecule approach to proteomics, strengthened the core leadership of our R&D team, and dramatically expanded our development organization, all while tightly and successfully managing operating expenses. We very much look forward to building on the successes of 2022 as we move through 2023 on our way to a commercial launch and beyond.”

Fiscal Year 2022 Financial Results

Operating expenses were $63.6 million for the year-ended December 31, 2022, a $13.1 million or 26% increase from $50.5 for the year ended December 31, 2021. The increase in operating expenses was driven primarily by an increase in headcount to support ongoing development of our products as well as the costs associated with being a public company.

Net loss was $57.9 million for the year-ended December 31, 2022, as compared to a net loss of $50.3 million for the corresponding prior year period.

Cash, cash equivalents, and investments were $313.6 million as of December 31, 2022.

Webcast and Conference Call Information

Nautilus will host a conference call to discuss the fourth quarter and fiscal year 2022 financial results, business developments and outlook before market open on Thursday, February 23, 2023 at 5:30 AM Pacific Time / 8:30 AM Eastern Time. Live audio of the webcast will be available on the “Investors” section of the company website at:

About Nautilus Biotechnology, Inc.

Based in Seattle, Washington, Nautilus is a development stage life sciences company creating a platform technology for quantifying and unlocking the complexity of the proteome. Nautilus’ mission is to transform the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. To learn more about Nautilus, visit

Special Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of federal securities laws. Forward-looking statements in this press release include, but are not limited to, statements regarding Nautilus’ expectations regarding the company’s business operations, financial performance and results of operations; expectations with respect to any revenue timing or projections, expectations with respect to the timing of the launch of Nautilus’ product platform and full commercial availability, the functionality and performance of Nautilus’ product platform, its potential impact on providing proteome access, pharmaceutical development and drug discovery, expanding research horizons, and enabling scientific explorations and discovery, and the present and future capabilities and limitations of emerging proteomics technologies. These statements are based on numerous assumptions concerning the development of Nautilus’ products, target markets, and other current and emerging proteomics technologies, and involve substantial risks, uncertainties and other factors that may cause actual results to be materially different from the information expressed or implied by these forward-looking statements. Risks and uncertainties that could materially affect the accuracy of Nautilus’ assumptions and its ability to achieve the forward-looking statements set forth in this press release include (without limitation) the following: Nautilus’ product platform is not yet commercially available and remains subject to significant scientific and technical development, which is inherently challenging and difficult to predict, particularly with respect to highly novel and complex products such as those being developed by Nautilus. Even if our development efforts are successful, our product platform will require substantial validation of its functionality and utility in life science research. In the course of Nautilus’ scientific and technical development and associated product validation and commercialization, we may experience material delays as a result of unanticipated events. We cannot provide any guarantee or assurance with respect to the outcome of our development, collaboration, and commercialization initiatives or with respect to their associated timelines. For a more detailed description of additional risks and uncertainties facing Nautilus and its development efforts, investors should refer to the information under the caption “Risk Factors” in our Annual Report on Form 10-K to be filed for the year ended December 31, 2022. The forward-looking statements in this press release are as of the date of this press release. Except as otherwise required by applicable law, Nautilus disclaims any duty to update any forward-looking statements. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.

Disclosure Information

Nautilus uses filings with the Securities and Exchange Commission, its website (, press releases, public conference calls, public webcasts, and its social media accounts as means of disclosing material non-public information and for complying with Regulation FD. Therefore, Nautilus encourages investors, the media, and others interested in Nautilus to review the information it makes public in these locations, as such information could be deemed to be material information.



Nautilus Biotechnology, Inc. Consolidated Balance Sheets As of December 31, 2022 and 2021 (Unaudited)

(in thousands) December 31,2022   December 31,2021
Current assets:      
Cash and cash equivalents $ 114,523     $ 185,619  
Short-term investments   69,948       160,110  
Prepaid expenses and other current assets   2,738       3,493  
Total current assets   187,209       349,222  
Property and equipment, net   3,700       2,483  
Operating lease right-of-use assets   28,866       29,377  
Long-term investments   129,169       16,371  
Other long-term assets   1,108       997  
Total assets $ 350,052     $ 398,450  
Liabilities and Stockholders’ Equity      
Current liabilities:      
Accounts payable $ 1,272     $ 1,723  
Accrued expenses and other liabilities   3,528       3,119  
Current portion of operating lease liability   1,991       970  
Total current liabilities   6,791       5,812  
Operating lease liability, net of current portion   28,337       29,062  
Total liabilities   35,128       34,874  
Stockholders’ equity:      
Preferred stock          
Common stock   12       12  
Additional paid-in capital   455,330       444,388  
Accumulated other comprehensive loss   (1,854 )     (184 )
Accumulated deficit   (138,564 )     (80,640 )
Total stockholders’ equity   314,924       363,576  
Total liabilities and stockholders’ equity $ 350,052     $ 398,450  

Nautilus Biotechnology, Inc. Consolidated Statements of Operations Three Months and Year Ended December 31, 2022 and 2021 (Unaudited)

  Three Months Ended December 31,   Year Ended December 31,
(in thousands, except share and per share amounts)   2022       2021       2022       2021  
Operating expenses:              
Research and development $ 9,587     $ 9,893     $ 37,672     $ 29,352  
General and administrative   6,717       6,923       25,946       21,146  
Total operating expenses   16,304       16,816       63,618       50,498  
Other income (expense):              
Interest income   2,887       160       5,816       329  
Other expense   8       (33 )     (122 )     (146 )
Total other income $ 2,895     $ 127     $ 5,694     $ 183  
Net loss $ (13,409 )   $ (16,689 )   $ (57,924 )   $ (50,315 )
Net loss per share attributable to common stockholders, basic and diluted $ (0.11 )   $ (0.13 )   $ (0.46 )   $ (0.60 )
Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted (1)   124,789,542       124,232,794       124,589,555       84,464,081  

(1) The weighted-average number of shares of Common Stock outstanding prior to the Business Combination have been retroactively restated to reflect the exchange ratio of approximately 3.6281 established in the Business Combination.

Nautilus Biotechnology, Inc. Consolidated Statements of Cash Flows Year Ended December 31, 2022 and 2021 (Unaudited)

(in thousands) Year Ended December 31, 2022   Year Ended December 31, 2021
Cash flows from operating activities      
Net loss $ (57,924 )   $ (50,315 )
Adjustments to reconcile net loss to net cash used in operating activities      
Stock-based compensation   10,380       7,934  
Amortization of operating lease right-of-use assets   2,199       1,823  
Depreciation   1,217       1,019  
Amortization (accretion) of premiums (discount) on securities, net   (890 )     183  
Changes in operating assets and liabilities:      
Prepaid expenses and other assets   756       (2,750 )
Accounts payable   (561 )     1,261  
Accrued expenses and other liabilities   409       2,255  
Operating lease liabilities   (1,392 )     (788 )
Net cash used in operating activities   (45,806 )     (39,241 )
Cash flows from investing activities      
Purchases of securities   (186,591 )     (221,795 )
Purchases of property and equipment   (2,324 )     (2,269 )
Proceeds from maturities of securities   163,175       85,100  
Net cash used in investing activities   (25,740 )     (138,964 )
Cash flows from financing activities      
Proceeds from exercise of stock options   330       167  
Proceeds from issuance of common stock under employee stock purchase plan   232        
Net proceeds from reverse recapitalization and PIPE financing         335,409  
Payments of offering costs         (8,129 )
Net (decrease) increase in cash, cash equivalents and restricted cash   (70,984 )     149,242  
Cash, cash equivalents and restricted cash at beginning of period   186,461       37,219  
Cash, cash equivalents and restricted cash at end of period $ 115,477     $ 186,461  
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