MediciNova Announces Abstract regarding the Mechanism by which MN-001 (tipelukast) Alters Triglyceride Metabolism Accepted for Presentation at the 19th International Symposium on Atherosclerosis (ISA2021)
October 21 2021 - 6:30AM
MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ
Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo
Stock Exchange (Code Number: 4875), today announced an abstract
entitled “MN-001 (tipelukast) reduces triglycerides levels in
hepatocytes by down-regulating fatty acid translocase/CD36
expression" has been selected for
presentation at the 19th International Symposium on
Atherosclerosis (ISA2021) to be held October 24 - 27, 2021 in a
hybrid format both online and onsite at the Kyoto International
Conference Center in Kyoto, Japan.
This study showed that MN-001 (tipelukast)
inhibited the uptake of arachidonic acid into hepatocytes and
suppressed the synthesis and accumulation of triglycerides (TG) in
hepatocytes. These phenomena, which are consistent with earlier
findings, suggested that MN-001 (tipelukast) reduced the synthesis
and accumulation of TG in hepatocytes by suppressing the expression
of CD36.
MediciNova’s research collaborator, Dr.
Masatsune Ogura, Associate Professor at the Department of
General Medical Science, Chiba University Graduate School of
Medicine, will present the results of the study. Dr. Ogura’s
e-presentation with narration will be accessible on the ISA2021
website from October 25 to November 30, 2021.
Kazuko Matsuda, M.D. Ph.D, MPH., Chief Medical
Officer, MediciNova, Inc., commented, “It has been observed that
MN-001 treatment reduces serum TG levels in multiple previous
clinical trials. Particularly, in a Phase 2 clinical trial with
hypertriglyceridemia subjects with NASH or NAFLD, MN-001
demonstrated a clinically meaningful and statistically significant
reduction in mean serum TG with no safety or tolerability issues.
We are very pleased that Dr. Ogura will present new findings
regarding the mechanism by which MN-001 alters intracellular
triglyceride metabolism.”
About MN-001
MN-001 (tipelukast) is a novel, orally
bioavailable, small molecule compound thought to exert its effects
through several mechanisms to produce its anti-inflammatory and
anti-fibrotic activity in preclinical models, including leukotriene
(LT) receptor antagonism, inhibition of phosphodiesterases (PDE)
(mainly 3 and 4), and inhibition of 5-lipoxygenase (5-LO). The
5-LO/LT pathway has been postulated as a pathogenic factor in
fibrosis development, and MN-001's inhibitory effect on 5-LO and
the 5-LO/LT pathway is considered to be a novel approach to treat
fibrosis. MN-001 has been shown to down-regulate expression of
genes that promote fibrosis including LOXL2, Collagen Type 1 and
TIMP-1. MN-001 has also been shown to down-regulate expression of
genes that promote inflammation including CCR2 and MCP-1. In
addition, histopathological data shows that MN-001 reduces fibrosis
in multiple animal models.
About MediciNova
MediciNova, Inc. is a clinical-stage
biopharmaceutical company developing a broad late-stage pipeline of
novel small molecule therapies for inflammatory, fibrotic, and
neurodegenerative diseases. Based on two compounds, MN-166
(ibudilast) and MN-001 (tipelukast), with multiple mechanisms of
action and strong safety profiles, MediciNova has 11 programs in
clinical development. MediciNova’s lead asset, MN-166 (ibudilast),
is currently in Phase 3 for amyotrophic lateral sclerosis (ALS) and
degenerative cervical myelopathy (DCM) and is Phase 3-ready for
progressive multiple sclerosis (MS). MN-166 (ibudilast) is also
being evaluated in Phase 2 trials in glioblastoma, patients at risk
of developing acute respiratory distress syndrome (ARDS), and
substance dependence. MN-001 (tipelukast) was evaluated in a Phase
2 trial in idiopathic pulmonary fibrosis (IPF) and is in
preparation for a second Phase 2 trial in nonalcoholic
steatohepatitis (NASH). MediciNova has a strong track record of
securing investigator-sponsored clinical trials funded through
government grants.
Statements in this press release that are not
historical in nature constitute forward-looking statements within
the meaning of the safe harbor provisions of the Private Securities
Litigation Reform Act of 1995. These forward-looking statements
include, without limitation, statements regarding the future
development and efficacy of MN-166, MN-001, MN-221, and MN-029.
These forward-looking statements may be preceded by, followed by or
otherwise include the words "believes," "expects," "anticipates,"
"intends," "estimates," "projects," "can," "could," "may," "will,"
"would," “considering,” “planning” or similar expressions. These
forward-looking statements involve a number of risks and
uncertainties that may cause actual results or events to differ
materially from those expressed or implied by such forward-looking
statements. Factors that may cause actual results or events to
differ materially from those expressed or implied by these
forward-looking statements include, but are not limited to, risks
of obtaining future partner or grant funding for development of
MN-166, MN-001, MN-221, and MN-029 and risks of raising sufficient
capital when needed to fund MediciNova's operations and
contribution to clinical development, risks and uncertainties
inherent in clinical trials, including the potential cost, expected
timing and risks associated with clinical trials designed to meet
FDA guidance and the viability of further development considering
these factors, product development and commercialization risks, the
uncertainty of whether the results of clinical trials will be
predictive of results in later stages of product development, the
risk of delays or failure to obtain or maintain regulatory
approval, risks associated with the reliance on third parties to
sponsor and fund clinical trials, risks regarding intellectual
property rights in product candidates and the ability to defend and
enforce such intellectual property rights, the risk of failure of
the third parties upon whom MediciNova relies to conduct its
clinical trials and manufacture its product candidates to perform
as expected, the risk of increased cost and delays due to delays in
the commencement, enrollment, completion or analysis of clinical
trials or significant issues regarding the adequacy of clinical
trial designs or the execution of clinical trials, and the timing
of expected filings with the regulatory authorities, MediciNova's
collaborations with third parties, the availability of funds to
complete product development plans and MediciNova's ability to
obtain third party funding for programs and raise sufficient
capital when needed, and the other risks and uncertainties
described in MediciNova's filings with the Securities and Exchange
Commission, including its annual report on Form 10-K for the year
ended December 31, 2020 and its subsequent periodic reports on Form
10-Q and current reports on Form 8-K. Undue reliance should not be
placed on these forward-looking statements, which speak only as of
the date hereof. MediciNova disclaims any intent or obligation to
revise or update these forward-looking statements.
INVESTOR CONTACT:Geoff O'BrienVice PresidentMediciNova,
Inc.info@medicinova.com
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