FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Ronsheim Matthew 2. Date of Event Requiring Statement (MM/DD/YYYY)
9/9/2020 

3. Issuer Name and Ticker or Trading Symbol Entasis Therapeutics Holdings Inc. [ETTX]
(Last)       (First)       (Middle)
C/O ENTASIS THERAPEUTICS HOLDINGS INC.,, 35 GATEHOUSE DRIVE
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
See Remarks /
(Street)
WALTHAM, MA 02451      
(City)             (State)             (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   (1) 9/16/2029  Common Stock  40000  $5.12  D   
Stock Option (Right to Buy)   (2) 12/18/2029  Common Stock  20000  $4.80  D   
Stock Option (Right to Buy)   (3) 1/14/2030  Common Stock  15000  $4.70  D   
Stock Option (Right to Buy)   (4) 8/16/2030  Common Stock  20000  $2.86  D   

Explanation of Responses:
(1)  Twenty-five percent (25%) of the shares subject to the option vested on August 20, 2020, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date.
(2)  Twenty-five percent (25%) of the shares subject to the option vested on August 20, 2020, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date.
(3)  Twenty-five percent (25%) of the shares subject to the option shall vest on January 1, 2021, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date.
(4)  Twenty-five percent (25%) of the shares subject to the option shall vest on August 17, 2021, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date.

Remarks:
Chief of Pharmaceutical Sciences and Manufacturing. Exhibit List - See Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Ronsheim Matthew
C/O ENTASIS THERAPEUTICS HOLDINGS INC.,
35 GATEHOUSE DRIVE
WALTHAM, MA 02451


See Remarks

Signatures
/s/ Elizabeth M. Keiley as Attorney-in-Fact for Matthew Ronsheim, Ph.D 9/11/2020
**Signature of Reporting Person Date
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