If the filing person has previously filed a statement on Schedule 13G
to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e),
240.13d-1(f) or 240.13d-1(g), check the following box. ¨
* The remainder of this cover page shall be filled out for a
reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page
shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).
CUSIP No. 28249H104
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1
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Names of Reporting Persons.
RA Capital Management, L.P.
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2
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Check the Appropriate Box if a Member of a Group (See Instructions)
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(a) ¨
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(b) ¨
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3
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SEC Use Only
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4
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Source of Funds (See Instructions):
AF
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5
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Check if disclosure of legal proceedings
is required pursuant to Items 2(d) or 2(e):
¨
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6
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Citizenship or Place of Organization. Delaware
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Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
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7
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Sole Voting Power 0
shares
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8
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Shared Voting Power 1,798,339
shares
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9
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Sole Dispositive Power 0
shares
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10
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Shared
Dispositive Power 1,798,339 shares
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11
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Aggregate Amount Beneficially Owned by
Each Reporting Person
1,798,339 shares
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12
|
Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ¨
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13
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Percent of Class Represented by Amount
in Row (11)
4.7%1
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14
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Type of Reporting Person (See Instructions)
IA, PN
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1
The reporting person is the beneficial owner of 1,798,339 shares of the Issuer’s Common Stock which constitute
approximately 4.66% of the class outstanding. The percentage calculation assumes that there are currently 38,571,002 outstanding
shares of Common Stock of the Issuer, based upon the closing of the Issuer’s 10-Q filed with the Securities and Exchange
Commission (“SEC”) on August 6, 2020.
CUSIP No. 28249H104
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1
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Names of Reporting Persons.
Peter Kolchinsky
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2
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Check the Appropriate Box if a Member of a Group (See Instructions)
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|
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(a) ¨
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|
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(b) ¨
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3
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SEC Use Only
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4
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Source of Funds (See Instructions):
AF
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5
|
Check if disclosure of legal proceedings
is required pursuant to Items 2(d) or 2(e):
¨
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6
|
Citizenship or Place of Organization. United
States
|
|
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
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7
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Sole Voting Power 0 shares
|
|
8
|
Shared Voting Power 1,798,339 shares
|
|
9
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Sole Dispositive Power 0 shares
|
|
10
|
Shared
Dispositive Power 1,798,339 shares
|
|
11
|
Aggregate Amount Beneficially Owned by
Each Reporting Person
1,798,339 shares
|
|
12
|
Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ¨
|
|
13
|
Percent of Class Represented by Amount
in Row (11)
4.7%2
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14
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Type of Reporting Person (See Instructions)
HC, IN
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2 The reporting person is the beneficial
owner of 1,798,339 shares of the Issuer’s Common Stock which constitute approximately 4.66% of the class outstanding. The
percentage calculation assumes that there are currently 38,571,002 outstanding shares of Common Stock of the Issuer, based upon
the closing of the Issuer’s 10-Q filed with the Securities and Exchange Commission (“SEC”) on August 6, 2020.
CUSIP No. 28249H104
|
1
|
Names of Reporting Persons.
Rajeev Shah
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2
|
Check the Appropriate Box if a Member of a Group (See Instructions)
|
|
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(a) ¨
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|
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(b) ¨
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3
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SEC Use Only
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|
4
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Source of Funds (See Instructions):
AF
|
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5
|
Check if disclosure of legal proceedings
is required pursuant to Items 2(d) or 2(e):
¨
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6
|
Citizenship or Place of Organization.
United States
|
|
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
|
7
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Sole Voting Power 0 shares
|
|
8
|
Shared Voting Power 1,798,339 shares
|
|
9
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Sole Dispositive Power 0 shares
|
|
10
|
Shared
Dispositive Power 1,798,339 shares
|
|
11
|
Aggregate Amount Beneficially Owned by
Each Reporting Person
1,798,339 shares
|
|
12
|
Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) ¨
|
|
13
|
Percent of Class Represented by Amount
in Row (11)
4.7%3
|
|
14
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Type of Reporting Person (See Instructions)
HC, IN
|
3 The reporting person is the beneficial
owner of 1,798,339 shares of the Issuer’s Common Stock which constitute approximately 4.66% of the class outstanding. The
percentage calculation assumes that there are currently 38,571,002 outstanding shares of Common Stock of the Issuer, based upon
the closing of the Issuer’s 10-Q filed with the Securities and Exchange Commission (“SEC”) on August 6, 2020.
CUSIP No. 28249H104
SCHEDULE 13D
This Amendment No.
1 amends and supplements the statement on Schedule 13D (the “Statement”) originally filed with the Securities and Exchange
Commission on July 2, 2018 by the Reporting Persons with respect to the Common Stock, $0.001 par value (the “Common Stock”),
of Eidos Therapeutics, Inc. (the “Issuer”). Unless otherwise defined herein, capitalized terms used in
this Amendment No. 1 shall have the meanings ascribed to them in the initial Statement.
Item 2. Identity and Background
(a) This Schedule 13D is being
filed on behalf of RA Capital Management, L.P. (“ RA Capital”), Peter Kolchinsky, and Rajeev Shah. RA Capital, Dr.
Kolchinsky, and Mr. Shah are collectively referred to herein as the “Reporting Persons.”
The Common Stock reported herein includes
1,460,403 shares held by RA Capital Healthcare Fund, L.P. (the “Fund”) and 337,936 shares held in a separately managed
account (the “Account”). RA Capital Healthcare Fund GP, LLC is the general partner of the Fund. The general partner
of RA Capital is RA Capital Management GP, LLC, of which Dr. Kolchinsky and Mr. Shah are the controlling persons. RA Capital serves
as investment adviser for the Fund and the Account and may be deemed a beneficial owner, for purposes of Section 13(d) of the Securities
Exchange Act of 1934 (the “Act”), of any securities of the Issuer held by the Fund or the Account. The Fund has delegated
to RA Capital the sole power to vote and the sole power to dispose of all securities held in the Fund’s portfolio, including
the shares of the Issuer’s Common Stock reported herein. Because the Fund has divested itself of voting and investment
power over the reported securities it holds and may not revoke that delegation on less than 61 days’ notice, the Fund disclaims
beneficial ownership of the securities it holds for purposes of Section 13(d) of the Act and therefore disclaims any obligation
to report ownership of the reported securities under Section 13(d) of the Act. As managers of RA Capital, Dr. Kolchinsky and Mr.
Shah may be deemed beneficial owners, for purposes of Section 13(d) of the Act, of any securities of the Issuer beneficially owned
by RA Capital. RA Capital, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of the
securities reported in this Schedule 13D Statement (the “Statement”) other than for the purpose of determining their
obligations under Section 13(d) of the Act, and the filing of the Statement shall not be deemed an admission that either RA Capital,
Dr. Kolchinsky, or Mr. Shah is the beneficial owner of such securities for any other purpose.
(b) The business address of each of
the Reporting Persons is: 200 Berkeley Street, 18th Floor, Boston, MA 02116.
Item 5. Interest in Securities of the Issuer
(a) and (b) See Items 7-11 of the cover
pages and Item 2 above.
(c) From the date of the initial Schedule
13D through October 5, 2020, the Reporting Persons participated in the following open market transactions of the Issuer’s
Common Stock:
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Transaction
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Date
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No. Shares
|
Price
|
|
Purchase
|
30-Sep-2020
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546* and 54
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$50.4967
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Purchase
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01-Oct-2020
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2,729* and 271
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$50.4113
|
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Sell
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05-Oct-2020
|
297,671* and 70,261
|
$73.5370
|
CUSIP No. 28249H104
Shares marked with an * were transacted
by the Fund. The remaining shares were transacted by the Account.
(d) None.
(e) As a result of the transactions reported
herein, none of the Reporting Persons beneficially owns more than 5% of the Issuer’s Common Stock, and therefore none of
the Reporting Persons remains subject to Section 13(d) of the Exchange Act with respect to the securities of the Issuer.
Item 7. Material to Be Filed as Exhibits
Exhibit 1 Joint Filing Agreement by
and among the Reporting Persons is incorporated herein by reference to Exhibit 1 to the Schedule 13D filed by the Reporting Persons
with the Securities and Exchange Commission on October 7, 2020.
CUSIP No. 28249H104
SIGNATURE
After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: October 7, 2020
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RA CAPITAL MANAGEMENT, L.P.
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By: /s/ Peter Kolchinsky
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Peter Kolchinsky
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Manager
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PETER KOLCHINSKY
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/s/ Peter Kolchinsky
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RAJEEV SHAH
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/s/ Rajeev Shah
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CUSIP No. 28249H104
Exhibit 1
JOINT FILING AGREEMENT
This Joint Filing Agreement,
dated as of October 7, 2020, is by and among RA Capital Management, L.P., Peter Kolchinsky, and Rajeev Shah (the foregoing are
collectively referred to herein as the “Filers”).
Each of the Filers
may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13G and/or 13D with respect
to Common Stock of Eidos Therapeutics, Inc. beneficially owned by them from time to time.
Pursuant to and in
accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to
file a single statement on Schedule 13G and/or 13D (and any amendments thereto) on behalf of each of such parties, and hereby further
agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule.
This Joint Filing Agreement
may be terminated by any of the Filers upon one week’s prior written notice or such lesser period of notice as the Filers
may mutually agree.
Executed and delivered
as of the date first above written.
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RA CAPITAL MANAGEMENT, L.P.
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|
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By: /s/ Peter Kolchinsky
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Peter Kolchinsky
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Manager
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|
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PETER KOLCHINSKY
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/s/ Peter Kolchinsky
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RAJEEV SHAH
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/s/ Rajeev Shah
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