FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * JIAN LI 2. Date of Event Requiring Statement (MM/DD/YYYY)
3/17/2022 

3. Issuer Name and Ticker or Trading Symbol DURECT CORP [DRRX]
(Last)        (First)        (Middle)
C/O DURECT CORPORATION, 10260 BUBB ROAD
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
InterimPrincipalAccountingOfcr /
(Street)
CUPERTINO, CA 95014      
(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock  20481  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   (1) 2/5/2023  Common Stock  139519  $1.21  D   
Stock Option (right to buy)   (1) 1/31/2024  Common Stock  106926  $2.09  D   
Stock Option (right to buy)   (1) 3/28/2024  Common Stock  11538  $1.36  D   
Stock Option (right to buy)   (1) 1/9/2025  Common Stock  125657  $0.88  D   
Stock Option (right to buy)   (1) 3/26/2025  Common Stock  8889  $1.75  D   
Stock Option (right to buy)   (1) 1/28/2026  Common Stock  95581  $1.16  D   
Stock Option (right to buy)   (1) 3/31/2026  Common Stock  11538  $1.35  D   
Stock Option (right to buy)   (1) 1/9/2027  Common Stock  115228  $1.31  D   
Stock Option (right to buy)   (1) 6/19/2027  Common Stock  11321  $1.40  D   
Stock Option (right to buy)   (1) 1/26/2028  Common Stock  128437  $1.24  D   
Stock Option (right to buy)   (1) 1/23/2029  Common Stock  75467  $0.5767  D   
Stock Option (right to buy)   (2) 1/23/2029  Common Stock  70000  $0.5767  D   
Stock Option (right to buy)   (2) 1/21/2030  Common Stock  75000  $2.11  D   
Stock Option (right to buy)   (2) 1/15/2031  Common Stock  70000  $2.03  D   
Stock Option (right to buy)   (2) 1/6/2032  Common Stock  105200  $0.871  D   
Stock Option (right to buy)   (2) 3/11/2032  Common Stock  50000  $0.5901  D   

Explanation of Responses:
(1)  The option is fully vested.
(2)  The option vests and becomes exercisable in installments of one-sixteenth (1/16) of the total number of shares at the end of each three month period following the grant date, subject to the Reporting Person providing continuous service to the Issuer through the applicable vesting date.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
JIAN LI
C/O DURECT CORPORATION
10260 BUBB ROAD
CUPERTINO, CA 95014


InterimPrincipalAccountingOfcr

Signatures
/s/ Jian Li 3/25/2022
**Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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