Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

JIAN LI

2. Date of Event Requiring Statement (MM/DD/YYYY) 3/17/2022

3. Issuer Name and Ticker or Trading Symbol

DURECT CORP [DRRX]

(Last) (First) (Middle)

C/O DURECT CORPORATION, 10260 BUBB ROAD

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director _____ 10% Owner
___X___ Officer (give title below) _____ Other (specify below)
InterimPrincipalAccountingOfcr /

(Street)

CUPERTINO, CA 95014

(City) (State) (Zip)

5. If Amendment, Date Original Filed(MM/DD/YYYY)

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	20481	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Option (right to buy)	⁽¹⁾	2/5/2023	Common Stock	139519	$1.21	D
Stock Option (right to buy)	⁽¹⁾	1/31/2024	Common Stock	106926	$2.09	D
Stock Option (right to buy)	⁽¹⁾	3/28/2024	Common Stock	11538	$1.36	D
Stock Option (right to buy)	⁽¹⁾	1/9/2025	Common Stock	125657	$0.88	D
Stock Option (right to buy)	⁽¹⁾	3/26/2025	Common Stock	8889	$1.75	D
Stock Option (right to buy)	⁽¹⁾	1/28/2026	Common Stock	95581	$1.16	D
Stock Option (right to buy)	⁽¹⁾	3/31/2026	Common Stock	11538	$1.35	D
Stock Option (right to buy)	⁽¹⁾	1/9/2027	Common Stock	115228	$1.31	D
Stock Option (right to buy)	⁽¹⁾	6/19/2027	Common Stock	11321	$1.40	D
Stock Option (right to buy)	⁽¹⁾	1/26/2028	Common Stock	128437	$1.24	D
Stock Option (right to buy)	⁽¹⁾	1/23/2029	Common Stock	75467	$0.5767	D
Stock Option (right to buy)	⁽²⁾	1/23/2029	Common Stock	70000	$0.5767	D
Stock Option (right to buy)	⁽²⁾	1/21/2030	Common Stock	75000	$2.11	D
Stock Option (right to buy)	⁽²⁾	1/15/2031	Common Stock	70000	$2.03	D
Stock Option (right to buy)	⁽²⁾	1/6/2032	Common Stock	105200	$0.871	D
Stock Option (right to buy)	⁽²⁾	3/11/2032	Common Stock	50000	$0.5901	D

Explanation of Responses:
(1)	The option is fully vested.
(2)	The option vests and becomes exercisable in installments of one-sixteenth (1/16) of the total number of shares at the end of each three month period following the grant date, subject to the Reporting Person providing continuous service to the Issuer through the applicable vesting date.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
JIAN LI C/O DURECT CORPORATION 10260 BUBB ROAD CUPERTINO, CA 95014			InterimPrincipalAccountingOfcr

Signatures
/s/ Jian Li		3/25/2022
^**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.