FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Sawicki Mark W 2. Date of Event Requiring Statement (MM/DD/YYYY)
2/25/2021 

3. Issuer Name and Ticker or Trading Symbol Cryoport, Inc. [CYRX]
(Last)       (First)       (Middle)
C/O CRYOPORT, INC., 112 WESTWOOD PLACE, SUITE 350
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Chief Scientific Officer /
(Street)
BRENTWOOD, TN 37027      
(City)             (State)             (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock  19000  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Option to purchase common stock   (1) 8/20/2025  Common Stock  11342  $3.07  D   
Option to purchase common stock   (2) 5/6/2026  Common Stock  7231  $1.87  D   
Option to purchase common stock   (3) 3/28/2028  Common Stock  68000  $8.65  D   
Option to purchase common stock   (4) 4/1/2029  Common Stock  90000  $12.79  D   
Option to purchase common stock   (5) 3/30/2030  Common Stock  100000  $16.93  D   
Option to purchase common stock   (6) 5/18/2027  Common Stock  11831  $3.21  D   
Option to purchase common stock   (7) 5/7/2025  Common Stock  77625  $7.80  D   

Explanation of Responses:
(1)  1/48th of the 156,400 options originally granted vested on the 19th of each month for forty-eight months beginning September 19, 2015.
(2)  1/48th of the 70,000 options originally granted vested on the 6th of each month for forty-eight months beginning June 6, 2016.
(3)  1/48th of the 68,000 options originally granted vested on the 28th of each month for forty-eight months beginning April 28, 2018.
(4)  1/48th of the 90,000 options originally granted vested on the 1st of each month for forty-eight months beginning May 1, 2019.
(5)  1/48th of the 100,000 options originally granted vested on the 30th of each month for forty-eight months beginning April 30, 2020.
(6)  1/48th of the 78,000 options originally granted vested on the 18th of each month for forty-eight months beginning June 18, 2017.
(7)  1/48th of the 77,625 options originally granted vested on the 7th of each month for forty-eight months beginning June 7, 2015.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Sawicki Mark W
C/O CRYOPORT, INC.
112 WESTWOOD PLACE, SUITE 350
BRENTWOOD, TN 37027


Chief Scientific Officer

Signatures
/s/ Mark W. Sawicki 3/4/2021
**Signature of Reporting Person Date