false000159509700015950972024-08-062024-08-06
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
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Date of Report (Date of earliest event reported): August 06, 2024 |
CORBUS PHARMACEUTICALS HOLDINGS, INC.
(Exact name of Registrant as Specified in Its Charter)
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Delaware |
001-37348 |
46-4348039 |
(State or Other Jurisdiction of Incorporation) |
(Commission File Number) |
(IRS Employer Identification No.) |
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500 River Ridge Drive |
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Norwood, Massachusetts |
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02062 |
(Address of Principal Executive Offices) |
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(Zip Code) |
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Registrant’s Telephone Number, Including Area Code: (617) 963-0100 |
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class
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Trading Symbol(s) |
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Name of each exchange on which registered
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Common Stock, par value $0.0001 per share |
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CRBP |
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The Nasdaq Capital Market |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 2.02 Results of Operations and Financial Condition.
Corbus Pharmaceuticals Holdings, Inc. (the “Company”) issued a press release on August 6, 2024, disclosing financial information and operating metrics for its fiscal quarter ended June 30, 2024 and discussing its business outlook. A copy of the Company’s press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.
Item 7.01 Regulation FD Disclosure.
See “Item 2.02 Results of Operations and Financial Condition” above.
The information in this Current Report on Form 8-K under Items 2.02 and 7.01, including the information contained in Exhibit 99.1, is being furnished to the Securities and Exchange Commission, and shall not be deemed to be “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section, and shall not be deemed to be incorporated by reference into any filing under the Securities Act of 1933 or the Securities Exchange Act of 1934, except as shall be expressly set forth by a specific reference in such filing.
Item 9.01 Financial Statements and Exhibits.
(d) The following exhibit is furnished with this report:
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
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Corbus Pharmaceuticals Holdings, Inc. |
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Date: |
August 6, 2024 |
By: |
/s/ Yuval Cohen |
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Name: Yuval Cohen Title: Chief Executive Officer |
Exhibit 99.1
Corbus Pharmaceuticals Reports Second Quarter 2024 Financial Results and Provides a Corporate Update
•Clinical update presented at ASCO 2024 for CRB-701 showed continued differentiated safety and encouraging efficacy in patients with metastatic urothelial cancer or cervical cancer
•CRB-701 Phase 1 dose escalation underway in USA and Europe for patients with metastatic urothelial cancer and other nectin-4 enriched tumors and is on schedule for completion in Q4 2024
•Cash runway extended through Q3 2027 with $147 million of cash & investments at June 30, 2024
Norwood, MA, August 6, 2024 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (“Corbus” or the “Company”), today provided a corporate update and reported financial results for the quarter ended June 30, 2024.
“We continue to make progress across our pipeline” said Yuval Cohen, Ph.D., Chief Executive Officer of Corbus. “Updated clinical data was presented at ASCO 2024 by our development partner CSPC for CRB-701 (SYS6002). The data provided further evidence of the differentiated safety and encouraging efficacy first presented at ASCO GU in January 2024. This larger dataset of patients increases our confidence that CRB-701 is clinically active. The emerging safety data was reassuring showing low rates of skin rash and peripheral neuropathy and rare grade 3 adverse events. During the quarter, we commenced dose escalation in our corresponding U.S. and European Phase 1 clinical trial of CRB-701, a significant milestone that builds on this promising data. Separately, we expect to dose the first patient in Q1 2025 for CRB-913, our highly peripherally restricted oral CB1 inverse agonist. We look forward to continuing to advance our programs across our pipeline over the course of this year,” concluded Dr. Cohen.
Key Corporate Updates
CRB-701:
•Encouraging additional data from Phase 1 study presented at ASCO in June 2024:
oResults demonstrated 44% ORR and 78% DCR in metastatic urothelial cancer (“mUC”) and 43% ORR and 86% DCR in cervical cancer to date at doses ≥ 1.2mg/Kg
oNo dose limiting toxicities (“DLTs”) have been observed to date in doses up to and including 4.5 mg/Kg
oThree cases of skin rash (including one grade 3) and one case of grade 1 neuropathy seen to date; all were resolved
oEarly pharmacokinetics (“PK”) data demonstrate consistently lower levels of free MMAE than enfortumab vedotin across all doses in the study, including 4.5 mg/Kg
•Dose escalation commenced in the Phase 1 clinical trial of CRB-701-01 in April 2024. The Phase 1 portion of the open label study design (NCT06265727), being conducted in the U.S. and Europe, will evaluate the safety, efficacy and PK of CRB-701 in participants with advanced solid tumors associated with high nectin-4 expression. The Phase 1 trial initiates with dose escalation followed by dose optimization and concludes with dose expansion to determine the recommended Phase 2 dose. The Company expects to complete the dose escalation phase in Q4 2024 and present the USA dose escalation data in Q1 2025.
CRB-913:
•CRB-913 is a second-generation highly peripherally restricted CB1 receptor inverse agonist designed to treat obesity. In a diet-induced obesity ("DIO") mouse model, CRB-913, as a monotherapy and in combination with incretin analogs (tirzepatide, semaglutide, or liraglutide), demonstrated a reduction in body weight in DIO mice and improvements were observed in body fat content, leptinemia, insulin resistance, liver triglycerides, liver fat deposits, and liver histology.
•The Company expects to commence a Phase 1 study in the first quarter of 2025.
CRB-601:
•CRB-601 is a high affinity and selective anti-αvβ8 monoclonal antibody that blocks the activation of TGFβ expressed on cancer cells in the tumor microenvironment. In pre-clinical models, CRB-601 demonstrates enhanced anti-tumor activity when combined with anti-PD-1 checkpoint inhibitor therapy compared to either single agent alone.
•In January 2024, the FDA cleared the IND for CRB-601, and the Company expects to initiate a Phase 1 study of CRB-601 in Q4 2024.
Financial Results for Quarter Ended June 30, 2024:
The Company reported a net loss of approximately $10.0 million, or a net loss per diluted share of $0.90 per share, for the three months ended June 30, 2024, compared to a net loss of approximately $8.8 million, or a net loss per diluted share of $2.05, for the same period in 2023.
Operating expenses increased by $2.8 million to approximately $11.0 million for the three months ended June 30, 2024, compared to $8.2 million in the comparable period in the prior year. The increase was primarily attributable to an increase of $2.0 million in CRB-701 clinical trial costs with our contract research organization ("CRO") and clinical sites, as well as $0.3 million in drug manufacturing costs for CRB-913 offset by a $0.5 million decrease in toxicology costs as we transition from pre-clinical to clinical phase for CRB-601.
The Company reported cash, cash equivalents and investments of $147 million at June 30, 2024. During the second quarter, the Company raised $35.6 million of net proceeds pursuant to the Company’s ATM program and subsequent to quarter end through August 1, 2024, the Company raised approximately an additional $28.8 million of net proceeds pursuant to the ATM program. The $147 million of cash, cash equivalents and investments at June 30, 2024 together with the $28.8 million of additional net proceeds raised through August 1, 2024 is expected to fund operations through Q3 2027, based on planned expenditures.
About Corbus
Corbus Pharmaceuticals Holdings, Inc. is a precision oncology company with a diversified portfolio and is committed to helping people defeat serious illness by bringing innovative scientific approaches to well understood biological pathways. Corbus’ pipeline includes CRB-701, a next-generation antibody drug conjugate that targets the expression of Nectin-4 on cancer cells to release a cytotoxic payload, CRB-601, an anti-integrin monoclonal antibody which blocks the activation of TGFβ expressed on cancer cells, and CRB-913, a highly peripherally restricted CB1 inverse agonist for the treatment of obesity. Corbus is
headquartered in Norwood, Massachusetts. For more information on Corbus, visit corbuspharma.com. Connect with us on Twitter, LinkedIn and Facebook.
Forward-Looking Statements
This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act, as amended, including those relating to the Company’s trial results, product development, clinical and regulatory timelines, including timing for completion of trials and presentation of data, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statements that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management’s current beliefs and assumptions.
These statements may be identified by the use of forward-looking expressions, including, but not limited to, “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “potential,” “predict,” “project,” “should,” “would” and similar expressions and the negatives of those terms. These statements relate to future events or our financial performance and involve known and unknown risks, uncertainties, and other factors on our operations, clinical development plans and timelines, which may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such factors include those set forth in the Company’s filings with the Securities and Exchange Commission. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.
All product names, logos, brands and company names are trademarks or registered trademarks of their respective owners. Their use does not imply affiliation or endorsement by these companies.
INVESTOR CONTACT:
Sean Moran
Chief Financial Officer
Corbus Pharmaceuticals
smoran@corbuspharma.com
Bruce Mackle
Managing Director
LifeSci Advisors, LLC
bmackle@lifesciadvisors.com
---tables to follow---
Corbus Pharmaceuticals Holdings, Inc.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(in thousands, except share and per share amounts)
(Unaudited)
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For the Three Months Ended June 30, |
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For the Six Months Ended June 30, |
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2024 |
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2023 |
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2024 |
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2023 |
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Operating expenses: |
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Research and development |
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$ |
6,865 |
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$ |
4,249 |
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$ |
12,627 |
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$ |
17,637 |
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General and administrative |
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4,123 |
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3,940 |
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7,984 |
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7,849 |
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Total operating expenses |
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10,988 |
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8,189 |
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20,611 |
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25,486 |
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Operating loss |
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(10,988 |
) |
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(8,189 |
) |
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(20,611 |
) |
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(25,486 |
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Other income (expense), net: |
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Other income, net |
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695 |
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183 |
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3,604 |
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412 |
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Interest income |
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906 |
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232 |
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1,568 |
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494 |
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Interest expense |
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(652 |
) |
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(1,008 |
) |
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(1,491 |
) |
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(1,948 |
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Change in fair value of derivative liability |
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11 |
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— |
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39 |
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— |
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Foreign currency transaction (loss) gain, net |
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31 |
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(2 |
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(5 |
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(1 |
) |
Other income (expense), net |
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991 |
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(595 |
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3,715 |
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(1,043 |
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Net loss |
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$ |
(9,997 |
) |
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$ |
(8,784 |
) |
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$ |
(16,896 |
) |
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$ |
(26,529 |
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Net loss per share, basic and diluted |
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$ |
(0.90 |
) |
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$ |
(2.05 |
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$ |
(1.75 |
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$ |
(6.27 |
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Weighted average number of common shares outstanding, basic and diluted |
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11,053,241 |
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4,277,701 |
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9,681,875 |
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4,229,894 |
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Comprehensive loss: |
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Net loss |
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$ |
(9,997 |
) |
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$ |
(8,784 |
) |
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$ |
(16,896 |
) |
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$ |
(26,529 |
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Other comprehensive (loss) income: |
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Change in unrealized (loss) gain on marketable debt securities |
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(59 |
) |
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45 |
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(387 |
) |
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103 |
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Total other comprehensive (loss) income |
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(59 |
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45 |
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(387 |
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103 |
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Total comprehensive loss |
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$ |
(10,056 |
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$ |
(8,739 |
) |
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$ |
(17,283 |
) |
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$ |
(26,426 |
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Corbus Pharmaceuticals Holdings, Inc.
Condensed Consolidated Balance Sheets
(in thousands, except share and per share amounts)
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June 30, 2024 (Unaudited) |
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December 31, 2023 |
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ASSETS |
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Current assets: |
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Cash and cash equivalents |
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$ |
23,686 |
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$ |
13,724 |
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Investments |
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123,339 |
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7,182 |
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Restricted cash |
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285 |
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192 |
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Prepaid expenses and other current assets |
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1,001 |
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2,448 |
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Total current assets |
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148,311 |
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23,546 |
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Restricted cash |
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385 |
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478 |
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Property and equipment, net |
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671 |
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973 |
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Operating lease right-of-use assets |
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2,612 |
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3,063 |
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Other assets |
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— |
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212 |
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Total assets |
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$ |
151,979 |
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$ |
28,272 |
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LIABILITIES AND STOCKHOLDERS’ EQUITY |
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Current liabilities: |
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Notes payable |
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$ |
77 |
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$ |
301 |
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Accounts payable |
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1,152 |
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3,179 |
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Accrued expenses |
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10,488 |
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11,030 |
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Derivative liability |
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— |
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39 |
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Operating lease liabilities, current |
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1,519 |
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1,437 |
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Loan payable |
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10,744 |
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15,908 |
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Total current liabilities |
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23,980 |
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31,894 |
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Other long-term liabilities |
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— |
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44 |
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Operating lease liabilities, noncurrent |
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2,456 |
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3,239 |
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Total liabilities |
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26,436 |
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35,177 |
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Stockholders’ equity |
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Preferred stock, $0.0001 par value; 10,000,000 shares authorized, no shares issued and outstanding at June 30, 2024 and December 31, 2023. |
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— |
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— |
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Common stock, $0.0001 par value; 300,000,000 shares authorized, 11,498,917 and 4,423,683 shares issued and outstanding at June 30, 2024 and December 31, 2023, respectively |
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1 |
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— |
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Additional paid-in capital |
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579,510 |
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429,780 |
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Accumulated deficit |
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(453,580 |
) |
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(436,684 |
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Accumulated other comprehensive loss |
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(388 |
) |
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(1 |
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Total stockholders’ equity (deficit) |
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125,543 |
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(6,905 |
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Total liabilities and stockholders’ equity |
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$ |
151,979 |
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$ |
28,272 |
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v3.24.2.u1
Document and Entity Information
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Aug. 06, 2024 |
Cover [Abstract] |
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Document Type |
8-K
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Amendment Flag |
false
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Document Period End Date |
Aug. 06, 2024
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Entity Registrant Name |
CORBUS PHARMACEUTICALS HOLDINGS, INC.
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Entity Central Index Key |
0001595097
|
Entity File Number |
001-37348
|
Entity Tax Identification Number |
46-4348039
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Entity Incorporation, State or Country Code |
DE
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Entity Address, Address Line One |
500 River Ridge Drive
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Entity Address, City or Town |
Norwood
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Entity Address, State or Province |
MA
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Entity Address, Postal Zip Code |
02062
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City Area Code |
617
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Local Phone Number |
963-0100
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Entity Information, Former Legal or Registered Name |
Not Applicable
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Written Communications |
false
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Soliciting Material |
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Pre-commencement Tender Offer |
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Pre-commencement Issuer Tender Offer |
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Title of 12(b) Security |
Common Stock, par value $0.0001 per share
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Trading Symbol |
CRBP
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Security Exchange Name |
NASDAQ
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Entity Emerging Growth Company |
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