FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Blouse Grant E.
2. Date of Event Requiring Statement (MM/DD/YYYY)
7/12/2021 

3. Issuer Name and Ticker or Trading Symbol

CATALYST BIOSCIENCES, INC. [CBIO]
(Last)        (First)        (Middle)

C/O CATALYST BIOSCIENCES, INC., 611 GATEWAY BOULEVARD, SUITE 710
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Chief Scientific Officer /
(Street)

SOUTH SAN FRANCISCO, CA 94080      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 1754 (1)D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)  (2)7/16/2028 Common Stock 30000 $12.21 D  
Stock Option (Right to Buy)  (3)7/30/2028 Common Stock 10000 $9.68 D  
Stock Option (Right to Buy)  (4)1/24/2029 Common Stock 18000 $7.97 D  
Stock Option (Right to Buy)  (5)1/23/2029 Common Stock 35000 $6.85 D  
Stock Option (Right to Buy)  (6)2/8/2031 Common Stock 38500 $5.89 D  
Stock Option (Right to Buy)  (7)6/16/2031 Common Stock 25000 $4.33 D  

Explanation of Responses:
(1) Includes shares purchased under the Issuer's 2018 Employee Stock Purchase Plan on various dates between February 11, 2019 and February 9, 2021.
(2) 25% of the shares subject to the option vested on the one-year anniversary of the vesting commencement date of July 2, 2018, and 1/48 of the shares subject to the option vested or will vest on each monthly anniversary of the vesting commencement date thereafter.
(3) 25% of the shares subject to the option vested on the one-year anniversary of the vesting commencement date of July 1, 2018, and 1/48 of the shares subject to the option vested or will vest on each monthly anniversary of the vesting commencement date thereafter.
(4) The option vested or will vest over a four (4) year period on each monthly anniversary of the vesting commencement date of January 24, 2019.
(5) The option vested or will vest over a four (4) year period on each monthly anniversary of the vesting commencement date of January 23, 2020.
(6) 25% of the shares subject to the option will vest on the one-year anniversary of the vesting commencement date of February 8, 2021, and 1/48 of the shares subject to the option will vest on each monthly anniversary of the vesting commencement date thereafter.
(7) 25% of the shares subject to the option will vest on the one-year anniversary of the vesting commencement date of June 16, 2021, and 1/48 of the shares subject to the option will vest on each monthly anniversary of the vesting commencement date thereafter.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Blouse Grant E.
C/O CATALYST BIOSCIENCES, INC.
611 GATEWAY BOULEVARD, SUITE 710
SOUTH SAN FRANCISCO, CA 94080


Chief Scientific Officer

Signatures
/s/ Faisal Shawwa Attorney-in-Fact for Grant E. Blouse7/15/2021
**Signature of Reporting PersonDate

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