FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Vifor (International) Ltd
2. Date of Event Requiring Statement (MM/DD/YYYY)
10/20/2021 

3. Issuer Name and Ticker or Trading Symbol

Cara Therapeutics, Inc. [CARA]
(Last)        (First)        (Middle)

RECHENSTRASSE 37
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          ___X___ 10% Owner
_____ Officer (give title below)        _____ Other (specify below)
(Street)

CH-9014 ST. GALLEN, V8       

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock, par value $0.001 per share 7396770 I See Notes (1)(2)(3)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares

Explanation of Responses:
(1) In addition to Vifor (International) Ltd., an entity formed under the laws of Switzerland ("Vifor (International)"), this Form 3 is being filed by Vifor Fresenius Medical Care Renal Pharma Ltd., an entity formed under the laws of Switzerland ("VFMCRP"), and Vifor Pharma Ltd., an entity formed under the laws of Switzerland ("Vifor Pharma" and together with Vifor and VFMCRP, the "Reporting Persons"). The business addresses for each of the Reporting Persons are listed above. Each of the Reporting Persons may be deemed to have a pecuniary interest in securities reported by it on this Form 3 (the "Subject Securities").
(2) VFMCRP's beneficial ownership of the common stock referred to herein is being reported solely because VFMCRP may be deemed to beneficially own 6,221,943 shares of Common Stock of Cara Therapeutics, Inc. as a result of its right to acquire such shares upon exercise of an option granted to it by Vifor (International). Vifor Pharma's beneficial ownership of the common stock referred to herein is being reported solely because Vifor Pharma may be deemed to beneficially own 7,396,770 shares of Common Stock of Cara Therapeutics, Inc. as a result of its indirect ownership of 100% of the equity interests of Vifor (International) and 55% of the equity interests of VFMCRP.
(3) Each of the Reporting Persons disclaims any beneficial ownership of any of the Subject Securities, except to the extent of any pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Vifor (International) Ltd
RECHENSTRASSE 37
CH-9014 ST. GALLEN, V8 

X

Vifor Pharma Ltd.
RECHENSTRASSE 37
CH-9014 ST. GALLEN, V8 

X

Vifor Fresenius Medical Care Renal Pharma Ltd.
RECHENSTRASSE 37
CH-9014 ST. GALLEN, V8 

X


Signatures
VIFOR (INTERNATIONAL) LTD., By: /s/ Georg Frey, Title: Head Legal Corporate, By: /s/ Markus Frenzen, Title: Group Treasurer10/21/2021
**Signature of Reporting PersonDate

VIFOR PHARMA LTD., By: /s/ Georg Frey, Title: Head Legal Corporate, By: /s/ Markus Frenzen, Title: Group Treasurer10/21/2021
**Signature of Reporting PersonDate

VIFOR FRESENIUS MEDICAL CARE RENAL PHARMA LTD., By: /s/ Georg Frey, Title: Head Legal Corporate, By: /s/ Markus Frenzen, Title: Group Treasurer10/21/2021
**Signature of Reporting PersonDate

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