FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Simon Amy
2. Date of Event Requiring Statement (MM/DD/YYYY)
3/16/2023 

3. Issuer Name and Ticker or Trading Symbol

Beam Therapeutics Inc. [BEAM]
(Last)        (First)        (Middle)

C/O BEAM THERAPEUTICS INC., 238 MAIN STREET
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
Chief Medical Officer /
(Street)

CAMBRIDGE, MA 02142      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 65129 (1)(2)D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)  (3)3/31/2031 Common Stock 79500 $80.04 D  
Stock Option (Right to Buy)  (4)1/31/2032 Common Stock 30000 $69.21 D  
Stock Option (Right to Buy)  (5)6/30/2032 Common Stock 10000 $38.71 D  
Stock Option (Right to Buy)  (6)1/31/2033 Common Stock 40000 $43.45 D  

Explanation of Responses:
(1) Includes 44,813, 15,000 and 5,000 restricted stock units ("RSUs") granted to the Reporting Person under the Issuer's 2019 Equity Incentive Plan on March 31, 2021, March 31, 2022 and June 30, 2022 respectively.
(2) Each RSU represents the contingent right to receive one share of the Issuer's common stock. The RSUs vest in four substantially equal installments on each of the first four anniversaries of the date of grant, subject to the Reporting Person's continued service with the Issuer through each vesting date. The March 31, 2021 RSUs grant was originally for 59,750 RSUs of which 14,937 RSUs have already vested.
(3) The option vests as to 25% on the first anniversary of the vesting commencement date, March 31, 2022, and at a rate of 2.78% each month thereafter until the option is fully vested.
(4) The option vests at a rate of 2.08% each month after January 31, 2022 until the option is fully vested.
(5) The option vests at a rate of 2.08% each month after June 30, 2022 until the option is fully vested.
(6) The option vests at a rate of 2.08% each month after January 31, 2022 until the option is fully vested.

Remarks:
Exhibit List: Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Simon Amy
C/O BEAM THERAPEUTICS INC.
238 MAIN STREET
CAMBRIDGE, MA 02142


Chief Medical Officer

Signatures
By: /s/ Christine Bellon, Attorney-in-Fact3/27/2023
**Signature of Reporting PersonDate


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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