Arvinas, Pfizer in Development Pact for Breast Cancer Treatment
July 22 2021 - 7:58AM
Dow Jones News
By Chris Wack
Arvinas Inc. and Pfizer Inc. said they entered into a global
collaboration to develop and commercialize ARV-471, an
investigational oral Proteolysis Targeting Chimera estrogen
receptor protein degrader, a well-known disease driver in most
breast cancers.
The companies said ARV-471 is currently in a Phase 2 dose
expansion clinical trial for the treatment of patients with
estrogen receptor positive/human epidermal growth factor receptor 2
negative locally advanced or metastatic breast cancer.
Under the terms of the agreement, Pfizer will pay Arvinas $650
million upfront. Pfizer will also make a $350 million equity
investment in Arvinas.
The companies will equally share worldwide development costs,
commercialization expenses, and profits.
ARV-471 currently is being evaluated as a treatment for
metastatic breast cancer in a Phase 1 dose escalation study, a
Phase 1b combination study with Pfizer's Ibrance palbociclib, and a
Phase 2 monotherapy dose expansion study. Arvinas and Pfizer expect
to initiate two additional trials of ARV-471 in 2021, including a
second Phase 1b combination trial with everolimus and a trial in
the neoadjuvant setting.
Arvinas is also eligible to receive up to $400 million in
approval milestones and up to $1 billion in commercial milestones,
in addition to sharing profits on ARV-471 worldwide.
Arvinas shares rose 6% to $82 in premarket trading.
Write to Chris Wack at chris.wack@wsj.com
(END) Dow Jones Newswires
July 22, 2021 07:50 ET (11:50 GMT)
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