Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* ADAMS STREET PARTNERS LLC	2. Issuer Name and Ticker or Trading Symbol Aptinyx Inc. [ APTX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) ONE NORTH WACKER DRIVE, SUITE 2700	3. Date of Earliest Transaction (MM/DD/YYYY) 7/9/2020
(Street) CHICAGO, IL 60606 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	7/9/2020		J	V	90124 ⁽¹⁾	A	$0	275244 ⁽²⁾	I	See footnote ⁽³⁾⁽⁴⁾
Common Stock								5030628 ⁽⁵⁾	I	See footnote ⁽⁶⁾⁽⁷⁾

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:
(1)	Represents 20,246 shares received by Adams Street Partnership Fund - 2002 U.S. Fund, L.P. (AS 2002 US), 18,583 shares received by Adams Street Partnership Fund - 2003 U.S. Fund, L.P. (AS 2003 US), 14,354 shares received by Adams Street Partnership Fund - 2004 U.S. Fund, L.P. (AS 2004 US), 19,995 shares received by Adams Street Partnership Fund - 2005 U.S. Fund, L.P. (AS 2005 US), 1,186 shares received by Brinson Partnership Fund - 2004 Primary Fund, L.P. (BPF 2004 Primary), 796 shares received by The 2004 Primary Brinson Partnership Fund Offshore Series Company Ltd. (BPF 2004 Offshore), 2,472 shares received by Brinson Partnership Fund Trust - 2004 Primary Fund (BPF 2004 Trust) and 12,492 shares received by The Bank of New York Mellon as Trustee for the HP Inc. Master Trust (HP Trust), in each case, for no consideration as part of an exempt pro-rata distribution of shares on July 9, 2020 by a fund controlled by a third-party manager.
(2)	Represents 61,833 shares held by AS 2002 US, 56,753 shares held by AS 2003 US, 43,838 shares held by AS 2004 US, 61,066 shares held by AS 2005 US, 3,622 shares held by BPF 2004 Primary, 2,431 shares held by BPF 2004 Offshore, 7,550 shares held by BPF 2004 Trust and 38,151 shares held by HP Trust. All such shares were received for no consideration as part of exempt pro-rata distributions of shares by a fund controlled by a third-party manager.
(3)	The shares owned by each of AS 2002 US, AS 2003 US, AS 2004 US, AS 2005 US, BPF 2004 Primary, BPF 2004 Offshore, BPF 2004 Trust and HP Trust (the aforementioned funds, the "Funds") may be deemed to be beneficially owned by Adams Street Partners, LLC, the general partner of AS 2002 US, AS 2003 US, AS 2004 US and AS 2005 US; which is the sub-advisor and acts under power of attorney with respect to BPF 2004 Primary, BPF 2004 Offshore and BPF 2004 Trust; and which is the advisor and acts under power of attorney with respect to HP Trust. Thomas S. Bremner, Jeffrey T. Diehl, Elisha P. Gould, Robin Murray and Fred Wang, each of whom is a partner of Adams Street Partners, LLC (or a subsidiary thereof), may be deemed to share voting and dispositive power over the shares held by the Funds.
(4)	Adams Street Partners, LLC and Thomas S. Bremner, Jeffrey T. Diehl, Elisha P. Gould, Robin Murray and Fred Wang disclaim beneficial ownership of the shares held by the Funds except to the extent of their pecuniary interest therein.
(5)	Represents 249,791 shares held by Adams Street 2008 Direct Fund, L.P. (AS 2008 Direct), 216,053 shares held by Adams Street 2009 Direct Fund, L.P. (AS 2009 Direct), 122,728 shares held by Adams Street 2010 Direct Fund, L.P. (AS 2010 Direct), 106,754 shares held by Adams Street 2011 Direct Fund LP (AS 2011 Direct), 691,176 shares held by Adams Street 2012 Direct Fund LP (AS 2012 Direct), 522,837 shares held by Adams Street 2013 Direct Fund LP (AS 2013 Direct), 711,151 shares held by Adams Street 2014 Direct Fund LP (AS 2014 Direct), 504,708 shares held by Adams Street 2015 Direct Venture/Growth Fund LP (AS 2015 Direct), 439,714 shares held by Adams Street 2016 Direct Venture/Growth Fund LP (AS 2016 Direct) and 1,465,716 shares held by Adams Street Venture/Growth Fund VI LP (AS VG VI).
(6)	The shares owned by each of AS 2008 Direct, AS 2009 Direct, AS 2010 Direct, AS 2011 Direct, AS 2012 Direct, AS 2013 Direct, AS 2014 Direct, AS 2015 Direct, AS 2016 Direct and AS VG VI (the aforementioned funds, the "Direct Funds") may be deemed to be beneficially owned by Adams Street Partners, LLC, the managing member of the general partner of each of AS 2008 Direct, AS 2009 Direct and AS 2010 Direct; and the managing member of the general partner of the general partner of AS 2011 Direct, AS 2012 Direct, AS 2013 Direct, AS 2014 Direct, AS 2015 Direct, AS 2016 Direct and AS VG VI. Thomas S. Bremner, Jeffrey T. Diehl, Elisha P. Gould, Robin Murray and Fred Wang, each of whom is a partner of Adams Street Partners, LLC (or a subsidiary thereof), may be deemed to share voting and dispositive power over the shares held by the Direct Funds.
(7)	Adams Street Partners, LLC and Thomas S. Bremner, Jeffrey T. Diehl, Elisha P. Gould, Robin Murray and Fred Wang disclaim beneficial ownership of the shares held by the Direct Funds except to the extent of their pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
ADAMS STREET PARTNERS LLC ONE NORTH WACKER DRIVE SUITE 2700 CHICAGO, IL 60606		X