FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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OMB Number: 3235-0287
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

PORTNOY DAVID		 2. Issuer Name and Ticker or Trading Symbol

CRYO CELL INTERNATIONAL INC [ CCEL ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    __X__ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chairman, Co-CEO
(Last)          (First)          (Middle)

700 BROOKER CREEK BLVD, SUITE 1800		 3. Date of Earliest Transaction (MM/DD/YYYY)

8/25/2022
(Street)

OLDSMAR, FL 34677
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock         102586 I By Spouse 
Common Stock         98162 I By 401K 
Common Stock 8/25/2022  M  70270 A$3.14 860742 D  
Common Stock         152882 I By Corporation (1)
Common Stock         15611 I as Custodian for Daughter 
Common Stock         9974 I As Custodian for Son (2)
Common Stock         59027 I By LLC 
Common Stock         199080 I By IRA 
Common Stock         55219 I By Corporation 
Common Stock         11352 I As Custodian for Son 
Common Stock         11242 I As Custodian for Son 
Common Stock         10783 I As Custodian for Son 
Common Stock         9122 I As Custodian for Daughter 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option $3.14 8/25/2022  M   70270    4/15/2016 4/15/2026 Common Stock 70270 $3.14 0 D  
Stock Option $7.92           3/8/2018 3/8/2023 Common Stock 23636  23636 D  
Stock Option $7.53           8/30/2019 8/30/2029 Common Stock 26243  26243 D  
Stock Option $7.28           12/20/2019 12/20/2029 Common Stock 23636  23636 D  
Stock Option $12.27           12/22/2021 (3)(4)12/22/2024 Common Stock 553  553 D  
Stock Option $12.27           12/22/2021 (3)(5)12/22/2028 Common Stock 280000  280000 D  
Stock Option $13.50           12/22/2021 (3)(4)12/22/2024 Common Stock 24447  24447 D  
Explanation of Responses:
(1) Shares of Common Stock held by Mayim Investment Limited Partnership as is David I. Portnoy my be deemed the beneficial owner as the managing member and owner of Mayim Management, LLC, which is the general partner of Mayim Management Limited Partnership, which is the general partner of Mayim Investment Limited Partnership.
(2) Shares of Common Stock held by uTIPu, Inc., as to which David I. Portnoy may be deemed the beneficial owner as the Chairman of the Board and Secretary.
(3) The stock options are subject to the approval of the 2022 Equity Incentive Plan, which vote is expected to occur at the Company's 2022 Annual Meeting.
(4) One-third of the stock options will vest on December 22, 2022, one-third will vest on December 22, 2023 and one-third on December 22, 2024.
(5) Stock options vest immediately if the price of the Company's common stock reaches $25.00 per share during the seven-year option term.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
PORTNOY DAVID
700 BROOKER CREEK BLVD
SUITE 1800
OLDSMAR, FL 34677		XXChairman, Co-CEO
Signatures
/s/ David Portnoy8/29/2022
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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