PGEN Precigen Inc

By Chris Wack

Precigen Inc. said the U.S. Food and Drug Administration has cleared its investigational new drug application to initiate the Phase 1/1b clinical trial of PRGN-3007 in advanced receptor tyrosine kinase-like orphan receptor 1-positive hematological and solid tumors.

The company said its PRGN-3007 is a first-in-class investigational therapy based on the next generation of its UltraCAR-T platform and incorporates intrinsic programmed cell death protein 1 blockade.

This first-in-human study of PRGN-3007 will be conducted in collaboration with the H. Lee Moffitt Cancer Center & Research Institute.

The Phase 1/1b clinical trial is designed to evaluate the safety and efficacy of PRGN-3007 in patients with advanced ROR1(+) hematological and solid tumors.

Precigen shares were up 8% to $4.93 in premarket trading.

Write to Chris Wack at chris.wack@wsj.com

(END) Dow Jones Newswires

October 26, 2021 08:34 ET (12:34 GMT)

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