Biogen to Discontinue Clinical Development of Potential Treatment for Alzheimer's
June 16 2021 - 05:24PM
Dow Jones News
By Stephen Nakrosis
Biogen Inc. said Wednesday it would discontinue clinical
development of gosuranemab, which was being investigated as a
potential treatment for Alzheimer's disease.
The company said its decision was based on results of its Phase
2 TANGO study of gosuranemab, an investigational anti-tau antibody.
Biogen said the treatment didn't meet its primary efficacy endpoint
"of change from baseline at week 78 on the Clinical Dementia Rating
Scale-Sum of Boxes compared to placebo in patients with mild
cognitive impairment due to Alzheimer's disease and mild
Alzheimer's disease dementia." The company also said the treatment
was well tolerated and safety outcomes were consistent with earlier
studies.
Alfred Sandrock, head of Research and Development at Biogen,
said, "While we are disappointed by the results of the Phase 2
study of gosuranemab, we know that the path to innovation is not a
straight line, and that we always learn from each trial." He also
said, "We are investing in a broad neuroscience pipeline, including
other tau approaches for Alzheimer's disease."
--Write to Stephen Nakrosis at stephen.nakrosis@wsj.com
(END) Dow Jones Newswires
June 16, 2021 17:16 ET (21:16 GMT)
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