Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* Neal James R	2. Issuer Name and Ticker or Trading Symbol PALISADE BIO, INC. [ PALI ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) C/O PALISADE BIO, INC., 5800 ARMADA DR., SUITE 210	3. Date of Earliest Transaction (MM/DD/YYYY) 4/27/2021
(Street) CARLSBAD, CA 92008 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Stock Option (Right to Buy)	$27.59	4/27/2021		A		849		⁽¹⁾	11/10/2027	Common Stock	849	⁽²⁾	849	D
Stock Option (Right to Buy)	$53.33	4/27/2021		A		3398		⁽³⁾	4/5/2028	Common Stock	3398	⁽⁴⁾	3398	D
Stock Option (Right to Buy)	$53.33	4/27/2021		A		1359		⁽⁵⁾	7/24/2028	Common Stock	1359	⁽⁶⁾	1359	D
Stock Option (Right to Buy)	$41.20	4/27/2021		A		5091		⁽⁷⁾	4/25/2029	Common Stock	5091	⁽⁸⁾	5091	D
Stock Option (Right to Buy)	$41.20	4/27/2021		A		1298		⁽⁹⁾	6/19/2029	Common Stock	1298	⁽¹⁰⁾	1298	D
Stock Option (Right to Buy)	$26.85	4/27/2021		A		4406		⁽¹¹⁾	7/10/2030	Common Stock	4406	⁽¹²⁾	4406	D

Explanation of Responses:
(1)	The stock option vested in four equal quarterly installments from the vesting commencement date.
(2)	Received in exchange for a stock option to acquire 31,250 shares of common stock of Leading BioSciences, Inc. ("LBS") for $0.75 per share, pursuant to the Agreement and Plan of Merger, dated December 16, 2020, among Seneca Biopharma Inc., Townsgate Acquisition Sub 1, Inc. and LBS (the "Merger"). Per the terms of the Merger, each share of LBS's common stock was converted into the right to receive 0.02719 shares of Seneca's common stock. In the Merger, the name of the Issuer was changed from Seneca Biopharma, Inc. to Palisade Bio, Inc.
(3)	The stock option vested according to the following schedule: 25% of the shares underlying the option vested on the grant date and the remaining 75% vested in three equal quarterly installments thereafter beginning on June 30, 2018.
(4)	Received in the Merger in exchange for a stock option to acquire 125,000 shares of LBS common stock for $1.45 per share.
(5)	The stock option vested according to the following schedule: 50% of the shares underlying the option vested on the grant date and the remaining 50% vested in two equal quarterly installments thereafter beginning on September 30, 2018.
(6)	Received in the Merger in exchange for a stock option to acquire 50,000 shares of LBS common stock for $1.45 per share.
(7)	The stock option vested according to the following schedule: 25% of the shares underlying the option vested on the grant date and the remaining 75% vested in three equal quarterly installments thereafter beginning on June 30, 2019.
(8)	Received in the Merger in exchange for a stock option to acquire 187,250 shares of LBS common stock for $1.12 per share.
(9)	The stock option is fully vested.
(10)	Received in the Merger in exchange for a stock option to acquire 47,758 shares of LBS common stock for $1.12 per share.
(11)	The stock option vests according to the following schedule: 25% of the shares underlying the option vests on the grant date and the remaining 75% vested in three equal quarterly installments thereafter beginning on September 30, 2020.
(12)	Received in the Merger in exchange for a stock option to acquire 162,069 shares of LBS common stock for $0.73 per share.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Neal James R C/O PALISADE BIO, INC. 5800 ARMADA DR., SUITE 210 CARLSBAD, CA 92008	X