Kala Pharmaceuticals, Inc. (NASDAQ:KALA), a biopharmaceutical company focused on the discovery, development and commercialization of innovative therapies for diseases of the eye, today announced that management will participate in the following virtual healthcare investor conferences in March.

H.C. Wainwright Global Life Sciences Conference Date: March 9-10, 2021 Pre-recorded presentation will be made available beginning Tuesday, March 9, 2021 at 7:00 am ET

Oppenheimer 31st Annual Healthcare Conference Date: Tuesday, March 16, 2021 Fireside Chat at 3:50 pm ET

To access the webcasts and subsequent archived recording of each presentation, please visit “Events” in the “Investors” section of the Kala website at http://kalarx.com

About Kala Pharmaceuticals, Inc. Kala is a biopharmaceutical company focused on the discovery, development, and commercialization of innovative therapies for diseases of the eye. Kala has applied its AMPPLIFY® mucus-penetrating particle (MPP) Drug Delivery Technology to two ocular therapies, EYSUVIS™ (loteprednol etabonate ophthalmic suspension) 0.25% for the short-term (up to two weeks) treatment of signs and symptoms of dry eye disease and INVELTYS® (loteprednol etabonate ophthalmic suspension) 1% for the treatment of post-operative inflammation and pain following ocular surgery. The Company also has a pipeline of preclinical development programs targeted to address unmet medical needs, including both front and back of the eye diseases. For more information on Kala, please visit www.kalarx.com.

Loraine Spreen loraine.spreen@kalarx.com 857-277-4842

Hannah Deresiewicz hannah.deresiewicz@sternir.com 212-362-1200

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