Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* Frieberg Jacob B.	2. Issuer Name and Ticker or Trading Symbol VACCINEX, INC. [ VCNX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) C/O VACCINEX, INC., 1895 MOUNT HOPE AVENUE	3. Date of Earliest Transaction (MM/DD/YYYY) 12/31/2020
(Street) ROCHESTER, NY 14620 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock								52866	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Option (Right to Acquire) ⁽¹⁾	⁽¹⁾							⁽¹⁾	⁽¹⁾	Common Stock	4420		44200	D
Option (Right to Acquire) ⁽¹⁾	⁽¹⁾							⁽¹⁾	⁽¹⁾	Common Stock	4420		44200	I	By Benbow Estates, Ltd. ⁽²⁾
Option (Right to Acquire) ⁽³⁾	⁽³⁾							⁽³⁾	⁽³⁾	Common Stock	4121		75000	I	By Gee Eff Services Limited ⁽⁴⁾
Stock Option (Right to Buy)	$13.60							⁽⁵⁾	9/15/2027	Common Stock	6396		6396	D
Stock Option (Right to Buy)	$5.26							⁽⁵⁾	3/30/2029	Common Stock	2501		2501	D
Stock Option (Right to Buy)	$7.78							⁽⁵⁾	⁽⁶⁾	Common Stock	7718		7718	D
Stock Option (Right to Buy)	$5.52							⁽⁵⁾	6/29/2029	Common Stock	2385		2385	D
Stock Option (Right to Buy)	$7.17							⁽⁵⁾	9/27/2029	Common Stock	1856		1856	D
Stock Option (Right to Buy)	$4.85							⁽⁵⁾	12/28/2029	Common Stock	2737		2737	D
Stock Option (Right to Buy)	$4.00							⁽⁵⁾	3/29/2030	Common Stock	3336		3336	D
Stock Option (Right to Buy)	$3.95							5/14/2021	⁽⁷⁾	Common Stock	15679		15679	D
Stock Option (Right to Buy)	$3.61							⁽⁵⁾	6/28/2030	Common Stock	3756		3756	D
Stock Option (Right to Buy)	$1.78							⁽⁵⁾	9/28/2030	Common Stock	7626		7626	D
Stock Option (Right to Buy)	$2.07	12/31/2020		A		6545		12/31/2020	12/29/2030	Common Stock	6545	$0.0 ⁽⁸⁾	6545	D

Explanation of Responses:
(1)	Limited partnership units of Vaccinex Products, LP, which are presently exchangeable into shares of Common Stock on a 1-for-10 basis at the holder's option.
(2)	Mr. Frieberg's spouse is the owner of Benbow Estates, Ltd. and Mr. Frieberg is an officer of Benbow Estates, Ltd. Mr. Frieberg disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.
(3)	Partnership interests in VX3 (DE) LP, or VX3, which are presently exchangeable into shares of Common Stock on a 1-for-0.05495 basis at the holder's option. On August 13, 2018, Gee Eff Services Limited entered into an exchange agreement with the Issuer and the other partners of VX3 that provides each VX3 partner the right to exchange all, but not less than all, of its partnership interests in VX3 for shares of Common Stock. The option has no expiration date.
(4)	Mr. Frieberg is the sole owner and President of Gee Eff Services Limited.
(5)	Exercisable in full as of the date of this report.
(6)	This option expires on May 14, 2029 or five years following retirement or cessation of services, whichever occurs first.
(7)	This option expires on May 12, 2030 or five years following retirement or cessation of services, whichever occurs first.
(8)	Pursuant to the Issuer's Director Compensation Program, in a transaction exempt under Rule 16b-3, the reporting person elected to receive these options in lieu of $8,750 for retainer and meeting fees during the fourth quarter of 2020. The number of options was calculated in accordance with the Black-Scholes valuation model and all such options are immediately exercisable.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Frieberg Jacob B. C/O VACCINEX, INC. 1895 MOUNT HOPE AVENUE ROCHESTER, NY 14620	X