U.S. to Launch Covid-19 Drug Research Starting With Eli Lilly Treatment
August 04 2020 - 2:10PM
Dow Jones News
By Thomas M. Burton
WASHINGTON -- The National Institutes of Health on Tuesday said
it is launching wide-ranging studies of potential Covid-19 drugs
known as monoclonal antibodies, the synthetic targeted versions of
proteins produced by recovered Covid-19 patients.
The potential drugs that emerge from the research could be among
the foremost medical treatments to prevent or treat infections with
the new coronavirus while the U.S. and world await possible
vaccines. Anthony S. Fauci, who heads the NIH institute overseeing
the work, said monoclonal antibodies have great potential because
they are specifically designed to block the virus from infecting a
human cell.
The National Institute of Allergy and Infectious Diseases, led
by Dr. Fauci, is sponsoring the clinical trials, which are part of
a government-industry collaboration known as ACTIV, for
Accelerating Covid-19 Therapeutic Interventions and Vaccines.
The beginning steps of the work will focus on one monoclonal
antibody from Eli Lilly & Co., called LY-CoV555, but are
expected to broaden to studies of a series of monoclonal antibodies
and even other antiviral drugs.
The first of two studies will initially involve 220 patients
with moderate disease who don't require hospitalization. Half will
get the Lilly drug, and half will get an intravenous saline
placebo. The study could expand to study other investigational
drugs.
The beginning stage of the trial will evaluate safety. If safety
is demonstrated, the study will convert into assessing the drug in
a total of 2,000 patients. The goal is to see if people can avoid
hospitalization or death by day 28 of the trial.
The second study will evaluate the Lilly drug, and later other
agents, in hospitalized patients. Dr. Fauci said results from the
trials are expected by late October or early November.
Lilly is separately studying its drug to see if it can prevent
Covid-19 infections among long-term-care residents.
Part of the funding for the ACTIV work will come from the
government's Operation Warp Speed, a cross-agency effort that is
spending billions of dollars to quickly ramp up drug and vaccine
production for Covid-19. The disease already has killed more than
155,000 people in the U.S., according to data Tuesday from Johns
Hopkins University.
"We're looking for big impact in disease," said Janet Woodcock,
a senior Food and Drug Administration official detailed to
Operation Warp Speed during the pandemic.
Government officials declined to specify during a press call how
many therapeutic agents will be studied in the ACTIV trials. NIH
Director Francis Collins said he expects there will be "several,"
with government officials trying to identify "the highest
priorities with the best science."
(END) Dow Jones Newswires
August 04, 2020 13:55 ET (17:55 GMT)
Copyright (c) 2020 Dow Jones & Company, Inc.
Eli Lilly (NYSE:LLY)
Historical Stock Chart
From Mar 2024 to Apr 2024
Eli Lilly (NYSE:LLY)
Historical Stock Chart
From Apr 2023 to Apr 2024