KPTI Karyopharm Therapeutics Inc

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES                                                                                   
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940                       

1. Name and Address of Reporting Person * Shacham Sharon	2. Issuer Name and Ticker or Trading Symbol Karyopharm Therapeutics Inc. [ KPTI ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                    _____ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) President & CSO
(Last)          (First)          (Middle) C/O KARYOPHARM THERAPEUTICS INC., 85 WELLS AVENUE	3. Date of Earliest Transaction (MM/DD/YYYY) 1/8/2020
(Street) NEWTON, MA 02459 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	1/8/2020		M(1)		10000	A	$4.752	753506 (2)	D
Common Stock	1/8/2020		S(1)		10000	D	$18.5705 (3)	743506	D
Common Stock	1/9/2020		M(4)		10000	A	$4.752	552139 (5)	I	By Spouse
Common Stock	1/9/2020		S(4)		10000	D	$19.188 (6)	542139	I	By Spouse
Common Stock	12/19/2019		G	V	17313	D	$0.00	0	I	By GRAT (7)
Common Stock	12/19/2019		G	V	17313	D	$0.00	0	I	By Spouse's GRAT (8)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (right to buy)	$4.752	1/8/2020		M (1)			10000	(9)	9/2/2023	Common Stock	10000	$0.00	430303	D
Stock Option (right to buy)	$4.752	1/9/2020		M (4)			10000	(9)	9/2/2023	Common Stock	10000	$0.00	386061	I	By Spouse

Explanation of Responses:
(1)	These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
(2)	Reflects the transfer of 12,372 shares from the Sharon Shacham 2016 Qualified Annuity Trust (the "GRAT") to the reporting person on December 12, 2019.
(3)	Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $18.34 to $18.82, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
(4)	These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.
(5)	Reflects the transfer of 12,372 shares from the Michael G. Kauffman 2016 Qualified Annuity Trust (the "Spouse's GRAT") to the spouse of the reporting person on December 12, 2019.
(6)	Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $18.885 to $19.34, inclusive. The spouse of the reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
(7)	Upon termination of the GRAT, 17,313 shares held by the GRAT were transferred to a trust, the beneficiaries of which share the reporting person's household. The reporting person disclaims beneficial ownership of the shares held by such individuals, and this report should not be deemed an admission that the reporting person is the beneficial owner of such individuals' shares for purposes of Section 16 or for any other purpose.
(8)	Upon termination of the Spouse's GRAT, 17,313 shares held by the Spouse's GRAT were transferred to a trust, the beneficiaries of which share the reporting person's household. The reporting person disclaims beneficial ownership of the shares held by such individuals, and this report should not be deemed an admission that the reporting person is the beneficial owner of such individuals' shares for purposes of Section 16 or for any other purpose.
(9)	This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on September 3, 2014, and the remaining 75% vested in 36 equal monthly installments thereafter.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Shacham Sharon C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON, MA 02459			President & CSO

Signatures
/s/Christopher B. Primiano, Attorney-in-Fact for Sharon Shacham		1/10/2020
**Signature of Reporting Person		Date