Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* SMITH CLARENCE EDWARD	2. Issuer Name and Ticker or Trading Symbol ProtoKinetix, Inc. [ PKTX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director __ X __ 10% Owner __ X __ Officer (give title below) _____ Other (specify below) President & CEO
(Last) (First) (Middle) 1845 COUNTRY ROAD #214	3. Date of Earliest Transaction (MM/DD/YYYY) 3/5/2019
(Street) ST. AUGUSTINE, FL 32084 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock ⁽¹⁾	4/1/2019		P		2000000	A	$0.05	61353833	D
Common Stock	3/5/2019		P		50000	A	$0.075	5071025	I	See footnote ⁽²⁾
Common Stock	3/22/2019		P		34700	A	$0.06	5105725	I	See footnote ⁽²⁾
Common Stock	3/26/2019		P		5300	A	$0.053	5111025	I	See footnote ⁽²⁾
Common Stock	3/26/2019		P		15000	A	$0.069	5126025	I	See footnote ⁽²⁾
Common Stock	3/26/2019		P		20000	A	$0.06	5146025	I	See footnote ⁽²⁾
Common Stock	3/27/2019		P		15000	A	$0.07	5161025	I	See footnote ⁽²⁾
Common Stock	3/28/2019		P		18700	A	$0.07	5179725	I	See footnote ⁽²⁾
Common Stock	3/28/2019		P		100000	A	$0.075	5279725	I	See footnote ⁽²⁾
Common Stock	3/29/2019		P		60000	A	$0.075	5339725	I	See footnote ⁽²⁾
Common Stock	4/1/2019		P		21300	A	$0.07	5361025	I	See footnote ⁽²⁾
Common Stock	4/1/2019		P		50000	A	$0.077	5411025	I	See footnote ⁽²⁾
Common Stock	4/2/2019		P		12000	A	$0.072	5423025	I	See footnote ⁽²⁾
Common Stock	4/2/2019		P		20000	A	$0.074	5443025	I	See footnote ⁽²⁾
Common Stock	4/3/2019		P		10000	A	$0.08	5453025	I	See footnote ⁽²⁾
Common Stock	4/4/2019		P		10000	A	$0.08	5463025	I	See footnote ⁽²⁾
Common Stock	4/5/2019		P		60000	A	$0.06	5523025	I	See footnote ⁽²⁾
Common Stock	4/8/2019		P		146667	A	$0.06	5669692	I	See footnote ⁽²⁾
Common Stock	4/9/2019		P		10000	A	$0.069	5679692	I	See footnote ⁽²⁾
Common Stock	4/9/2019		P		152000	A	$0.07	5831692	I	See footnote ⁽²⁾
Common Stock	4/10/2019		P		94242	A	$0.07	5925934	I	See footnote ⁽²⁾
Common Stock	4/10/2019		P		66667	A	$0.069	5992601	I	See footnote ⁽²⁾
Common Stock	4/11/2019		P		9000	A	$0.064	6001601	I	See footnote ⁽²⁾
Common Stock	4/11/2019		P		19000	A	$0.067	6020601	I	See footnote ⁽²⁾
Common Stock	4/15/2019		P		10000	A	$0.063	6030601	I	See footnote ⁽²⁾
Common Stock	4/15/2019		P		5000	A	$0.066	6035601	I	See footnote ⁽²⁾
Common Stock	4/15/2019		P		38000	A	$0.07	6073601	I	See footnote ⁽²⁾
Common Stock								1850000	I	See footnote ⁽³⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Stock Option	$0.09							⁽⁴⁾	11/8/2023	Common Stock	5000000		5000000	D
Stock Option	$0.06							⁽⁵⁾	8/31/2021	Common Stock	5000000		5000000	D
Stock Option	$0.05							⁽⁶⁾	12/31/2020	Common Stock	5000000		5000000	D
Stock Option	$0.08							⁽⁷⁾	12/31/2019	Common Stock	5000000		5000000	D

Explanation of Responses:
(1)	Shares purchased by Mr. Smith from the Company in a private placement.
(2)	Shares held by the Clarence E. Smith Trust and purchased on the open market.
(3)	Shares held by Mr. Smith's retirement account.
(4)	Options granted pursuant to Amended 2017 Stock Option and Stock Bonus Plan. On March 31, 2019, 1,250,000 shares vest; thereafter 1,250,000 shares vest each quarter.
(5)	Options granted pursuant to 2017 Stock Option and Stock Bonus Plan. On December 31, 2017, 1,250,000 shares vested; thereafter 1,250,000 shares vested each quarter.
(6)	Options granted pursuant to 2017 Stock Option and Stock Bonus Plan. On March 31, 2017, 1,250,000 shares vested; thereafter 1,250,000 shares vested each quarter.
(7)	Options granted pursuant to 2015 Stock Option and Stock Bonus Plan. On March 31, 2016, 1,250,000 shares vested; thereafter 1,250

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
SMITH CLARENCE EDWARD 1845 COUNTRY ROAD #214 ST. AUGUSTINE, FL 32084	X	X	President & CEO

Signatures
/s/ Clarence E. Smith		4/11/2019
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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