FORM 5
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
[ ] Form 3 Holdings Reported
[ ] Form 4 Transactions Reported 		UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

                                                                                  

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Ranoux Claude

2. Issuer Name and Ticker or Trading Symbol

INVO Bioscience, Inc. [ivob]

5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      __ X __ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)

(Last)          (First)          (Middle)

8 CHESTNUT STREET

3. Statement for Issuer's Fiscal Year Ended (MM/DD/YYYY)
12/31/2018 
(Street)

WINCHESTER, MA 01890

(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person


Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4) 		7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount (A) or (D) Price
INVO BIOSCIENCE Common Stock   1/2/2018     S   600   D $0.155   26177997   D    
INVO BIOSCIENCE Common STOCK   1/2/2018     S   100   D $0.15   26177897   D    
INVO BIOSCIENCE Common Stock   1/4/2018     S   2134   D $0.146   26175763   D    
INVO BIOSCIENCE Common Stock   1/5/2018     S   500000   D $0.05   25675763   D    
INVO BIOSCIENCE Common Stock   1/5/2018     S   50000   D $0.12   26625763   D    
INVO BIOSCIENCE Common Stock   1/5/2018     S   20000   D $0.125   25605763   D    
INVO BIOSCIENCE Common Stock   1/8/2018     S   30000   D $0.144   25575763   D    
INVO BIOSCIENCE Common Stock   1/11/2018     S   5100   D $0.15   25570663   D    
INVO BIOSCIENCE Common Stock   1/12/2018     S   7445   D $0.145   25562218   D    
INVO BIOSCIENCE Common Stock   1/16/2018     S   600   D $0.145   25562618   D    
INVO BIOSCIENCE Common Stock   1/19/2018     S   3000   D $0.125   25559618   D    
INVO BIOSCIENCE Common Stock   1/22/2018     S   10000   D $0.116   25549618   D    
INVO BIOSCIENCE Common Stock   1/22/2018     S   20000   D $0.117   25529618   D    
INVO BIOSCIENCE Common Stock   1/22/2018     S   13500   D $0.1195   25516118   D    
INVO BIOSCIENCE Common Stock   1/25/2018     S   2100   D $0.119   25514018   D    
INVO BIOSCIENCE Common Stock   1/29/2018     S   31319   D $0.115   25482699   D    
INVO BIOSCIENCE Common Stock   1/31/2018     S   100   D $0.117   25482599   D    
INVO BIOSCIENCE Common Stock   2/1/2018     S   9500   D $0.117   25473099   D    
INVO BIOSCIENCE Common Stock   2/1/2018     S   1100   D $0.116   25471999   D    
INVO BIOSCIENCE Common Stock   2/2/2018     S   8000   D $0.116   25463999   D    
INVO BIOSCIENCE Common Stock   2/6/2018     S   100   D $0.112   25463899   D    
INVO BIOSCIENCE Common Stock   2/7/2018     S   16015   D $0.1115   25447884   D    
INVO BIOSCIENCE Common Stock   2/9/2018     S   1000   D $0.1115   25446884   D    
INVO BIOSCIENCE Common Stock   2/13/2018     S   11808   D $0.11   25435076   D    
INVO BIOSCIENCE Common Stock   2/14/2018     S   100   D $0.11   25434976   D    
INVO BIOSCIENCE Common Stock   2/15/2018     S   11050   D $0.11   25423926   D    
INVO BIOSCIENCE Common Stock   2/16/2018     S   2740   D $0.11   25421186   D    
INVO BIOSCIENCE Common Stock   2/20/2018     S   100   D $0.1114   25421086   D    
INVO BIOSCIENCE Common Stock   2/20/2018     S   23260   D $0.11   25397826   D    
INVO BIOSCIENCE Common Stock   2/20/2018     S   25000   D $1080   25372826   D    

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date
(MM/DD/YYYY) 		7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4) 		10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4) 		11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Explanation of Responses:

Remarks:
The table of Form-5 reported the first thirty transactions of 2018. The eleven other transactions for year 2018 will be reported on another Form-5 which will follow.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Ranoux Claude
8 CHESTNUT STREET
WINCHESTER, MA 01890
X


Signatures
Claude Ranoux 2/1/2018
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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